ISMRM25 - Preclinical Brain & Beyond

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Preclinical Brain & Beyond

Power Pitch

Preclinical

Wednesday, 14 May 2025

Power Pitch Theatre 1

08:15 - 10:15

Moderators: Zhifeng Liang & Georgios Batsios

Session Number: PP-22

No CME/CE Credit

08:15		Screen Number: 1 0820. Magnetic Field Correlation Imaging Quantifies Demyelination and Axonal Loss View Presentation Video L. Kitchingman, A. Hertanu, M. Jallais, K. Şimşek, O. Girard, G. Duhamel, L. Soustelle, R. Turner, E. Kopanoglu, I. Jelescu, M. Palombo Cardiff University, Cardiff, United Kingdom Impact: Magnetic Field Correlation imaging provides quantitative information on changes to myelin status complementary to other MRI techniques, and offers new ways to characterise microstructural changes in neurodegenerative diseases.
08:17		Screen Number: 2 0821. Quantitative comparison of multi-echo spin echo and multi-echo gradient echo myelin water imaging in a panel of Mbp-enhancer edited mouse strains View Presentation Video V. Grouza, Y. Shi, S. Goldfarb, K. Bednarz, M. Tuznik, H. Bagheri, A. Peterson, T. Stroh, D. Rudko Montreal Neurological Institute and Hospital, Montreal, Canada Impact: This study establishes mGRE-based MWF as a reliable alternative to MESE, offering shorter scan times and improved resolution for myelin imaging in preclinical models. It advances the potential of myelin water imaging in translational research and future clinical applications.
08:19		Screen Number: 3 0822. Magnetic Resonance Elastography Detects Whole Brain Stiffness Reductions during Acute Bacterial-Induced Neuroinflammation View Presentation Video S. Vander Wiele, L. Williams, K. Milbocker, E. Zarate, A. Klintsova, C. Johnson University of Delaware, Newark, United States Impact: This study is the first to quantify the brain mechanical response due to bacterial infection-induced acute neuroinflammation. These results may be useful in understanding the connection between acute neuroinflammatory events and the onset of neurodegenerative disease.
08:21		Screen Number: 4 0823. Detection of Diffuse White Matter Damage in a Sheep Model of Blast-Induced Traumatic Brain Injury Using SS3T diffusion MRI View Presentation Video S. Pathak, D. Cortes, R. Mejia-Alvarez, J. Manfredi, Y. Wu, W. Schneider University of Pittsburgh, PITTSBURGH, United States Impact: This work enhances the detection of diffuse white matter damage following bTBI by utilizing advanced diffusionMRI techniques, enabling earlier and more precise identification of injuries that conventional imaging might miss, thus improving the potential for effective interventions.
08:23		Screen Number: 5 0824. Assessment of white matter disconnection and Ferroptosis in chronic kidney disease mouse View Presentation Video Z. Yu, Z. Lin, D. Wu Zhejiang University, Hangzhou, China Impact: CKD-associated cognitive impairment is predominantly caused by the ferroptosis-induced dysconnectivity and destruction of the rich-club subnetwork, especially in the hippocampus. The ferroptosis-inhibitor-resveratrol may serve as the therapeutic method for improving cognitive function in CKD patients.
08:25		Screen Number: 6 0825. Diffusion MRI Reveals Distinct Abnormalities in the Spinal Cord Following Unilateral Dorsal Column Lesion and Sensory Nerve Root Injury View Presentation Video F. Wang, L. M. Chen, J. Gore Vanderbilt University Medical Center, Nashville, United States Impact: Neurite orientation dispersion and density imaging (NODDI) offers specific and sensitive metrics to assess early spinal cord structural changes post-injury. NODDI detects cysts after dorsal column lesion and subtle alterations in the dorsal root entry zone after sensory root injury.
08:27		Screen Number: 7 0826. Quantitative UTE Imaging of the Intervertebral Disc in a Rabbit Spine Disc Puncture Model View Presentation Video J. Athertya, A. Suprana, J. Lo, S. Jerban, K. Red, Y. Ge, M. Brown, K. Masuda, Y. Ma Department of Radiology, UCSD, San Diego, United States Impact: The proposed quantitative UTE imaging techniques enable comprehensive assessment of the IVD degeneration and may improve understanding of the mechanism of low back pain.
08:29		Screen Number: 8 0827. Resting-state functional connectivity in mouse cervical spinal cord at 15.2T View Presentation Video T-W Lee, F. Wang, A. Sengupta, A. Mishra, L. M. Chen, J. Gore Vanderbilt University, Nashville, United States Impact: This work shows the potential to detect BOLD signals in mouse spinal cords and derive network characteristics in mouse models of different disorders.
08:31		Screen Number: 9 0828. Simultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease View Presentation Video F. Mandino, X. Shen, C. Fredericks, S. Strittmatter, E. Lake Yale School of Medicine, New Haven, United States Impact: Relative to men, women face twice the lifetime risk of AD-related cognitive impairment. Causes of this discrepancy are unknown and understudied–especially in animal models. We report a novel dual-imaging framework for studying sex- and AD-related network disruption in mice.
08:33		Screen Number: 10 0829. Tissue-susceptibility matched electrodes for simultaneous magnetic resonance imaging A. von Raven Max Planck Institute for biological cybernetics, Tuebingen, Germany Impact: The presented electrode is an alternative to conventional electrodes, especially at ultrahigh field strengths. Since it was possible to perform simultaneous echo-planar imaging and voltage recording, those electrodes could be used for animal experiments to gain improved functional information.
08:35		Screen Number: 11 0830. Brain metabolism profile predicts the upregulation of cold-stress proteins after hypothermia in murine hypoxia-ischemia View Presentation Video X. Liu, A. Capper, N. Stewart, X. Jiang, W. Byrne, X. Ji, J. Ellison, D. Xu, D. Ferriero UCSF, San Francisco, United States Impact: The cold stress protein, i.e., CIRP levels could be used as one of the hypothermia-regulated targets to promote the TH effect on those who are not responsive to the hypothermia.
08:37		Screen Number: 12 0831. 1H-[13C] MR spectroscopic imaging of dynamic glucose metabolism in rat brain in vivo View Presentation Video R. de Graaf, M. Thomas, H. De Feyter Yale University, New Haven, United States Impact: ¹H-[¹³C]-MRSI is characterized by unique spectral features not offered by other dynamic metabolic imaging methods (HP, DMI). The ability to separate cerebral Glu from Gln and detect total and ¹³C-labeled pools makes ¹H-[¹³C]-MRSI an unique and valuable metabolic imaging method.
08:39		Screen Number: 13 0832. Brain metabolic alterations in murine models of retinal degeneration using parahydrogen-polarized [1-13C]pyruvate MRI. View Presentation Video S. Matsumoto, S. Suto, H. Hirata Hokkaido University, Sapporo, Japan Impact: Hyperpolarized [1-¹³C]pyruvate MRI revealed metabolic alterations in the brain of murine models with retinal degradation, reflecting serotoninergic activity and behavioral abnormalities often undetected by anatomical ¹H MRI in the absence of overt neurodegeneration.
08:41		Screen Number: 14 0833. Application of zero-echo time imaging for whole brain activity mapping without signal loss in mice. View Presentation Video A. Imamura, R. Araki, Y. Takahashi, K. Miyatake, F. Kato, S. Honjoh, T. Tsurugizawa Ph. D. Program in Humanics, University of Tsukuba, Tsukuba, Japan Impact: This study demonstrates ZTE fMRI’s capacity to image activation in the amygdala, even during pain responses, enabling previously challenging investigations into nociception-related networks. This breakthrough opens new avenues for studying pain pathways and emotion regulation, with potential translational relevance.
08:43		Screen Number: 15 0834. Resolve 3D choroid plexus structure and partitioned bidirectional cerebrospinal fluid flow with MRI View Presentation Video X. Zhou, X. Liu, D. Glen, X. Yu Athinoula A. Martinos Center for Biomedical Imaging, Boston, United States Impact: Our findings clarify choroid plexus morphology and its crucial role in regulating bidirectional CSF flow dynamics. This study reveals novel CSF hydrodynamics controlled by ChP localization, informing therapeutic strategies to target ChP function in degenerative or hydrocephalic conditions.
08:45		Screen Number: 16 0835. Structural MRI Analysis of Pregnancy-Related Brain Region Volumetric Changes in Mice: A Step Toward a Translational Animal Model View Presentation Video A. Korotcov, M. Kutschman, T. Adebayo, S. Purnomuo, S. Anisowicz, M. Hood, T. J. Wu Uniformed Services University of the Health Sciences, Bethesda, United States Impact: This study an attempt to establish a foundational mouse model to explore pregnancy-related brain reorganization based on volumetric changes across brain regions. Further exploration could advance understanding of maternal brain plasticity and inform research on cognitive and emotional health postpartum.
08:47		Screen Number: 17 0836. Resting State Interoception Network Integrates Multi-Organ Representations Via Peripheral Neural Pathways View Presentation Video F. Alkaabi, X. Wang, M. Choi, Z. Liu University of Michigan, Ann Arbor, United States Impact: We report that the resting brain actively processes interoceptive signals and forms overlapping representations of the heart, lungs, and gut through peripheral neural pathways. Our findings challenge the notion that bodily physiological fluctuations are vascular artifacts to fMRI.
08:49		Screen Number: 18 0837. Optogenetic fMRI of Pontine Reticular Nucleus for Mapping Respiratory Networks View Presentation Video T. Jin, G. H. Im, S-H Choi, T. Vo, S. Han, S-G Kim Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of Impact: This study introduces a method to distinguish global vascular responses from neural-driven BOLD responses, enabling investigations into respiratory circuits and identifying previously unreported sites involved in respiratory control.
08:51		Screen Number: 19 0838. Restoring Motor and Cognitive Functions with Dentate Nucleus DBS through Enhancing Brain Functional Connectivity in PTI-Induced Stroke Model View Presentation Video S-J Li, C-W Chang, Y-W Liang, T-C Chen, C-R Yang, Y-C Lo, S-H Lin, Y-Y Chen National Yang Ming Chiao Tung University, Taipei City, Taiwan Impact: This study highlights DN DBS as a potential therapeutic intervention for post-stroke rehabilitation, bridging preclinical insights to clinical applications for improved patient outcomes.
08:53		Screen Number: 20 0839. CBV mapping reveals regional brain activity changes in rats following longitudinal focal Transcranial Magnetic Stimulation (TMS) C. Li, S. Hoffman, H. Nguyen, A. Vrana, A. Carney, Y. Duan, Z. Ma, N. Zhang, Y. Yang, H. Lu The Pennsylvania State University, University Park, United States Impact: This is the first awake rat model that replicates the focality and temporal patterns of TMS conditions in humans, opening a novel platform further investigating TMS-induced neuroplasticity.
08:55		Screen Number: 21 0840. Accelerated neuromodulation in treatment-resistant depression: preclinic model characterization and treatment evaluation by multimodal MRI View Presentation Video V. Zecca, M. Boffa, S. Spalletti, C. Cerri, M. Bertone, T. Singh, G. Palombelli, M. Pettorruso, F. Zoratto, R. Canese Istituto Superiore di Sanità, Rome, Italy Impact: Our results show that increasing daily stimulation frequency allows to shorten treatment duration without compromising rTMS efficacy. The application of accelerated neuromodulation in clinical settings would improve patient compliance and cost-effectiveness.
08:57		Screen Number: 22 0841. Preclinical ¹H MRS at Ultra-High Field: A Comparative Study of LASER and STEAM Sequences in Mouse Brain View Presentation Video A. Abaei, D. K. Deelchand, F. Roselli, V. Rasche Ulm University, Ulm, Germany Impact: LASER's higher SNR can reduce scan time in preclinical studies at UHF, enabling more efficient data acquisition and facilitating advanced applications like dynamic MRS and neurochemical profiling of smaller brain structures.
08:59		Screen Number: 23 0842. MouseFlow: a pipeline for mouse brain diffusion MRI data, generating tractograms and diffusion metrics with quality controls View Presentation Video E. Cosenza, A. Boré, A. Valcourt Caron, V. Ozenne, A. Trotier, M. Descoteaux, S. Miraux, L. Petit Groupe d’Imagerie Neurofonctionnelle – Institut des Maladies Neurodégénératives (GIN-IMN), UMR5293 CNRS, Université de Bordeaux, Bordeaux, France Impact: MouseFlow enables researchers studying the rodent brain to standardise diffusion MRI workflows, improving reproducibility and comparability between studies. It facilitates studying brain connectivity in healthy and pathological conditions, advancing translational neuroscience with more robust and reliable data.
09:01		Screen Number: 24 0843. Sex differences in functional connectivity and behavior in a mouse model of alcohol abuse disorder: functional implication of Nucleus Accumbens. View Presentation Video P. Ortiz-Teba, M. Sourty, M. Rame, L. Degiorgis, L. Harsan ICube Laboratory, University of Strasbourg, CNRS, Strasbourg, France Impact: Combining behavioral and functional connectivity analyses, enabled the identification of connectome profiles by sex and AUD subtype. Emphasizing the lateralized role of the Nucleus Accumbens, nuanced by sex and AUD subtype. These insights inform targeted sex- and phenotype-adapted AUD interventions.
09:03		Screen Number: 25 0844. Common coordinate frameworks of developmental marmoset brain from birth to adolescence based on ultra-high-resolution diffusion MRI View Presentation Video T. Zhu, Z. Zhang, J. Guo, M. Ouyang, A. Sousa, J. Levine, A. Kriegstein, H. Huang Children's Hospital of Philadelphia, Philadelphia, United States Impact: The first developmental marmoset brain CCFs from birth to adolescence will allow integrating spatially resolved and molecularly defined cell atlas with studies of developing brain function, neurophysiology, and behavior. They will provide insights into evolution and human-specific features of brain development relevant to brain disorders.

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