ISMRM25 - Physical Chemistry Approaches for Contrast Mechanisms I

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Physical Chemistry Approaches for Contrast Mechanisms I

Sunrise Course

ORGANIZERS: Laura Bell, Shaihan Malik, Marco Palombo, Cristian Tejos

Monday, 12 May 2025

312

07:00 - 08:00

Moderators: Ye Tian & Nathan Williamson

Skill Level: Intermediate to Advanced

Session Number: S-M-07

No CME/CE Credit

Session Number: S-M-07

Overview
The rich history of MRI is marked by techniques evolving from physical chemistry, encompassing, for example, spectroscopy, diffusion, exchange, and quantum filters. This session delves into the contemporary landscape of NMR physical chemistry, exploring untapped methods for integration into MRI scanners. Addressing the shift from in vitro to in vivo applications, practical considerations will be explored. Furthermore, variations in hardware performance will be considered, shedding light on factors influencing the translation of innovative methods into successful MRI applications.

Target Audience
Scientists interested in pushing the boundaries of MR contrasts, aiming toward translating novel techniques from other fields (e.g. chemical-physics) to tissue microstructure imaging.

Educational Objectives
As a result of attending this course, participants should be able to:
• List advanced NMR methods and their Integration into medical applications of MRI;
• Describe how transitioning from in vitro to in vivo applications in NMR and MRI happens; and
• Evaluate hardware performance and its impact on NMR-MRI method translation.

07:00		Massive Multi-Dimensional Encodings (Relaxation & Diffusion) View Presentation Video Paddy Slator Impact: Combined diffusion-relaxation MRI enhances microstructural imaging by measuring diffusion and relaxation properties simultaneously. This talk covers key principles, data acquisition, preprocessing, and analysis, highlighting applications in the brain, prostate, and placenta.
07:30		Water Exchange Measurements with Filter Encoding (Relaxation & Diffusion) View Presentation Video Ruiliang Bai Impact: Vascular water exchange imaging (VEXI) and relaxation exchange imaging (REXI). This talk covers how they were developed for blood-brain barrier and blood-CSF barrier characterized, respectively, the key principles, data acquisition, and analysis, highlighting applications in the aging and brain diseases.