ISMRM25 - Physical Chemistry Approaches for Contrast Mechanisms II

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Physical Chemistry Approaches for Contrast Mechanisms II

Sunrise Course

ORGANIZERS: Laura Bell, Shaihan Malik, Marco Palombo, Cristian Tejos

Tuesday, 13 May 2025

323AB

07:00 - 08:00

Moderators: Thomas Mareci & Laura Walkup

Skill Level: Intermediate to Advanced

Session Number: S-T-07

No CME/CE Credit

Session Number: S-T-07

Overview
The rich history of MRI is marked by techniques evolving from physical chemistry, encompassing, for example, spectroscopy, diffusion, exchange, and quantum filters. This session delves into the contemporary landscape of NMR physical chemistry, exploring untapped methods for integration into MRI scanners. Addressing the shift from in vitro to in vivo applications, practical considerations will be explored. Furthermore, variations in hardware performance will be considered, shedding light on factors influencing the translation of innovative methods into successful MRI applications.

Target Audience
Scientists interested in pushing the boundaries of MR contrasts, aiming toward translating novel techniques from other fields (e.g. chemical-physics) to tissue microstructure imaging.

Educational Objectives
As a result of attending this course, participants should be able to:
• List advanced NMR methods and their Integration into medical applications of MRI;
• Describe how transitioning from in vitro to in vivo applications in NMR and MRI happens; and
• Evaluate hardware performance and its impact on NMR-MRI method translation.

07:00		Making the Leap From In Vitro to In Vivo (How To Make Translation Happen) View Presentation Video Rasim Boyacioglu Impact: How to move qMRI techniques into clinical workflows
07:30		Beyond the Image: Surfing the Spectral Wave of Hyperpolarized Xenon-129 View Presentation Video Kai Ruppert Impact: HXe-129 MRI pairs vivid ventilation maps with spectroscopy to reveal gas exchange. CSSR quantifies septal wall thickness while CSI maps regional deficits, enabling early detection and targeted evaluation of lung diseases.