ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Traditional Poster

What's on the Horizon for Contrast Mechanisms

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What's on the Horizon for Contrast Mechanisms
Traditional Poster
Monday, 12 May 2025
Building:   Room: Exhibition Hall
08:15 -  09:15
Session Number: T-12
No CME/CE Credit

  4745. Further Insights into (ih)MT: Four-Pool Model Analysis Accounting for Dipolar Order in ex vivo White Matter
N. Wallstein, A. Pampel, A. Sandgaard, C. Jäger, R. Müller, H. Möller
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Impact: Experimental evidence was provided for the need for an ‘extended 4PM’ with dipolar reservoirs. Systematic deviations in the z-spectra were resolved by a ‘free lineshape’ model, providing enhanced sensitivity to tissue microstructure (e.g., cylindrical arrangement of myelin).  
  4746. Turbo Spin Echo Imaging at 7T with Bilateral Orthogonality Generative Acquisitions Method for Homogeneous T1,T2 and Proton Density Contrasts
Ç. Boğa, A. Henning
UT Southwestern Medical Center , Dallas, United States
Impact: TSE application of BOGA method can accelerate the clinical utilization of 7T, as the B1+ inhomogeneity effects  are removed from the final contrast without any prior data acquisitions.
  4747. Towards an understanding of radiation-induced R1 changes in irradiated water on an MR linear accelerator
B. Tran, L. Lawrence, S. Binda, R. Oglesby, B. Chugh, A. Lau
University of Toronto, Toronto, Canada
Impact: An understanding of the mechanism behind radiation-induced R1 changes could determine if radiation beam effects can be imaged in other systems and in vivo.
  4748. Inferring conduction velocity properties from qMRI-derived Structural Myelin Integrity (SMI) using qMT and MWF
M. Corral-Bolaños, H. Vila-Merkle, M. Pizzolato, T. Dyrby
Technical University of Denmark, Kongens Lyngby, Denmark
Impact: We introduce a new myelin metric that directly links myelin’s structural properties to signal conduction velocity, addressing the limitations of MWF and qMT. It opens new research opportunities into myelin dynamics related to its functional properties.
  4749. Biomechanical evaluation of muscle-tendon unit rehabilitation following treatment in patellar tendinopathy patients by combined DTI and MRE
M. Salimi Majd, M. Lerchbaumer, H. Tzschätzsch, S. Kim, A. Agres, T. Meyer, S. Görner, J. Braun, I. Sack, J. Guo
Charité - Universitätsmedizin Berlin, Berlin, Germany
Impact: The new anisotropic MRE method showed unique sensitivity to subtle structural changes in quadriceps muscles of patellar tendinopathy patients. The anisotropic biomechanical properties may aid in diagnosing tendinopathy and assessing the muscle-tendon unit rehabilitation following treatment.
  4750. Fast, Motion-Robust, Multi-Contrast MRI of the Human Brain using Triplanar 2D EPI acquisitions and Super-Resolution Reconstruction
M. Adam, B. Bachrátá, W. Bogner, S. D. Robinson
Medical University of Vienna, Vienna, Austria
Impact: The inability of many patients to lie still during MRI leads to motion-corrupted images. Fast imaging with multiple contrasts could make a significant contribution to imaging patients with diseases which make it difficult to stay still, such as Parkinson's disease.
  4751. Rotary Excitation based imaging of multi-frequency stimulus fields in the human brain: a method for optimization of deep brain stimulation?
P. Albertova, L. Torres, M. Blaimer, M. Wessel, M. Reich, P. Jakob, P. Nordbeck, M. Gram
University Hospital Würzburg, Würzburg, Germany
Impact: So far, non-invasive methods for patient-specific imaging of evoking fields induced by deep-brain-stimulation (DBS) do not exist. REX-based imaging could enable structured assessment of stimulation target regions via MRI and thus support the calibration and clinical testing of neurostimulation devices.
  4752. 9.4T MRI-derived myelin measures in post-mortem brain blocks reveal unprecedented spatial characteristics in Multiple Sclerosis lesions
D. Gkotsoulias, I. Callegari, J. Leupold, M. Reisert, E. Bahn, J. Franz, B. Dhital, D. von Elverfeldt, V. Kiselev, M. Weigel, C. Stadelmann, C. Granziera
University of Basel, Basel, Switzerland
Impact: The unprecedented spatial resolution and contrast obtained in post-mortem brain blocks imaged 9.4T MRI open a new window into the assessment of mechanisms leading to focal pathology appearance and evolution in Multiple Sclerosis.
  4753. Using DANTE T1-SPACE and Sandwich Neuromelanin Sequences to differentiate Data-Driven Parkinson’s Disease Subtypes
M-C Kuo, Y-C Shih, R-J Lin, S-H Chen, Y-F Wei, H-Y Yang, J. O. S. Goh
Graduate Institute of Medicine, Yuan Ze University, Taoyuan City, Taiwan
Impact: Understanding potential and limitations of novel neuromelanin-related sequences in PD subtype differentiation.
  4754. Evaluating the performance of poroelastic and poroviscoelastic models in intrinsic MR elastography
M. Burman Ingeberg, E. van Houten, J. Zwanenburg
UMC Utrecht, Utrecht, Netherlands
Impact: These results directly contribute to the improvement of iMRE by addressing previous limitations and by demonstrating the feasibility of poro(visco)elastic reconstruction, potentially enabling novel ways of studying cerebral microvasculature and (mechanical) neurovascular coupling in the brain. 
  4755. 50 Years after Relaxometry: The Performance of Three Quantitative MRI Methodologies in the Real World
G. Zhao, J. Teng, L. Zhang, Y. Wu, M. Wang, M. Nittka, Y. Ran, F. Chen, H. Zheng, Y. Zhang, J. Cheng
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: This study highlights the need for standardized relaxometry protocols or rigorous data screening to minimize bias, enabling reliable T1/T2 imaging analysis and advancing clinical translation.
  4756. Characterizing nearly incompressible transversely isotropic (NITI) biological tissue with MR elastography
S. Ma, Z. He, R. Wang, A. Zhang, Q. Sun, J. Liu, F. Yan, M. Sacks, X-Q Feng, G-Z Yang, Y. Feng
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
Impact: The TWE-NITI method offers an accurate and fast way to measure fiber-reinforced tissues in vivo, showing the potential application of anisotropic MRE. Furthermore, the proposed framework may also help solving the inverse problem in other fields. 
  4757. Technical Foundation of Magnetic Resonance Elastography in the Peripheral Nervous System
H. Fels-Palesandro, G. Mangin, I. Faras, S. Heiland, M. Bendszus, K. Schregel, R. Sinkus
Heidelberg University Hospital, Heidelberg, Germany
Impact: MRE is feasible in peripheral nerves and 2D-MRE delivers correct biomechanical information in optimized in-vitro examination conditions, thus serving as built-up for optimization of 3D-MRE in peripheral nerves and clinical translation.
  4758. Single-isocenter Multi-target Stereotactic Radiotherapy: An MR Gel Dosimetry Protocol to Evaluate Accuracy
J. Fischer, B. Thomann, U. Ludwig, T. Fechter, D. Baltas, M. Bock
, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Impact: This multicenter study aims to strengthen the trust in SIMT SRS, which has the potential to significant time savings for medical personnel and machine time as well as improvements to patient comfort.
  4759. The severity of brain changes measured by MR fingerprinting in patients with White Matter Hyperintensities
G. Zhao, L. Sun, M. Wang, M. Nittka, J. Cheng, Y. Zhang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: Our study's outcomes can enhance clinical assessments of brain white matter abnormalities. This impacts patients, healthcare providers, and researchers by allowing for more efficient and accurate diagnosis and understanding of previously challenging issues, thereby improving patient care and outcomes.
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