ISMRM25 - Novel Spectroscopy in Traditional Posters

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Novel Spectroscopy in Traditional Posters

Traditional Poster

Wednesday, 14 May 2025

Building: Room: Exhibition Hall

14:30 - 15:30

Session Number: T-13

No CME/CE Credit

		5230. High Resolution in vivo preclinical 1H-FID-MRSI using Compressed Sensing : when acceleration leads to precipitation PDF Poster B. Alves, T. Lê, A. Klauser, W. Bogner, B. Lanz, B. Strasser, C. Cudalbu Centre d'Imagerie Biomedical - CIBM, Lausanne, Switzerland Impact: 1H-MRSI combined with CS could be useful for dynamic measurements over multiple repetitions. For higher resolution acquisition, the technique could be more suitable for 3D whole-brain acquisition or in combination with other acceleration techniques.
		5231. AI-Powered Accurate Lipid Segmentation for Lipid Removal from Brain MRSI Data PDF Poster Y. Zhang, Z. Ke, W. Jin, R. Liu, D. Wang, W. Zhang, J. Li, Y. Li, Z-P Liang University of Illinois at Urbana-Champaign, Urbana, United States Impact: The proposed method will significantly improve the robustness of lipid removal and help generate high-quality metabolite maps from brain MRSI data, especially those obtained without lipid suppression.
		5232. Differences in metabolic behavior of liver metastases of colorectal carcinoma: [18F]FDG-PET vs. DMI at 7T. PDF Poster L. S. Ho, A. Braat, M. Konig, M. Gosselink, D. Klomp, M. Lam, J. Prompers University Medical Center Utrecht, Utrecht, Netherlands Impact: This study demonstrates that deuterium metabolic imaging can reveal distinct metabolic features in liver metastases of colorectal cancer, complementing [¹⁸F]FDG-PET by distinguishing necrotic and active tumor tissue, and thus providing a promising non-invasive tool for metabolic assessment in liver metastases.
		5233. WITHDRAWN
		5234. Bayesian posterior estimation for MR spectral quantification using diffusion probabilistic model PDF Poster Y. Djebra, J. Ouyang, C. Ma Yale University, School of Medicine, New Haven, United States Impact: This study enables fast and reliable MRS parameters value and uncertainty assessment, significantly accelerating conventional methods. Patient diagnosis using this approach could benefit from precise metabolite assessment with informed margin of error, potentially broadening MRS clinical utility.
		5235. Application of MRspecLAB for MRS/MRSI Data Processing: A Low-Code, and Highly Flexible GUI Platform PDF Poster Y. Xiao, A. Kaiser, M. H. J. Kockisch, R. Carlet, Z. Huang, X. Liu, A. Döring, M. Widmaier, L. Xin Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland Impact: MRspecLAB shows the large potential for users to easily process both ¹H and X-nuclei MRS/MRSI raw data. This collaborative environment also enhances accessibility to MRS/MRSI techniques for various research and clinical applications.
		5236. Effect on spectral quantification of Back-Linear-Predicted and original first order dephased 1H-FID-MRSI data PDF Poster A. Siviglia, B. Alves, J. Mosso, C. Cudalbu, B. Lanz CIBM Center for Biomedical Imaging , Lausanne, Switzerland Impact: The presented work revealed that with enough fitting baseline flexibility, FID-MRSI quantification at a theoretical reconstructed AD=0ms can achieve unbiased measurements, while it indicated that direct FID-MRSI quantification at AD≠0ms might generate systematic estimation offsets.
		5237. Convolutional Network Based Lineshape Adaptation Improved Subject-Specific Subspace Estimation for MRSI Reconstruction R. Zhao, Z. Wang, F. Lam University of illinois, Urbana Chamapign, Champaign, United States Impact: The proposed method minimized the discrepancy between physics-driven subspace and in vivo data, improving subspace-based MRSI reconstruction and quantification.
		5238. Quantification of T1 and T2 Metabolite Relaxation Times in Healthy Brain at 7T PDF Poster D. Lai, R. Goldberg, C. Fleischer Georgia Institute of Technology and Emory University, Atlanta, United States Impact: T₁ and T₂ relaxation times of brain metabolites were measured at 7T in the same subjects and scan session. Previously unreported relaxation times were quantified for several metabolites, which are useful for optimizing acquisition parameters and quantifying absolute metabolite concentrations.
		5239. Functional Magnetic Resonance Spectroscopy at 7 Tesla: Examining Glutamate & Lactate Dynamics during Processing Speed PDF Poster A. Kaiser, Y. Xiao, M. Widmaier, L. Xin CIBM Center for Biomedical Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland Impact: Our findings highlight the potential of fMRS to detect dynamic neurochemical changes during cognitive tasks, offering valuable insights for understanding cognitive processing and decline. This could have profound implications for neuroscience and psychiatric research in diagnosing cognitive disorders.
		5240. Cryogenic RF coil versus higher magnetic field strength for 1H fast FID-MRSI in the rat brain PDF Poster T. P. Lê, B. Alves, J. Mosso, B. Lanz, C. Cudalbu CIBM Center for Biomedical Imaging, Lausanne, Switzerland Impact: High quality metabolite quantification and mapping with fast ¹H FID-MRSI is achieved in the rat brain benefiting from either the unmatched sensitivity of cryogenic coils at 9.4T, or enhanced spectral resolution at 14.1T.
		5241. The consequences of statistical tests on proxy variables, an application to short-TE as an estimation for MEGA-edited GABA PDF Poster K. Landheer, M. Treacy, C. Juchem Regeneron Genetics Center, Tarrytown, United States Impact: The false negative and false positive rate can be markedly inflated when using short-TE MRS to estimate metabolites such as gamma-aminobutyric acid. This calls for increased caution in interpreting results, and the accommodation of these effects when designing statistical analyses.
		5242. Oriented Object Detection Deep Learning Model for Automated Prescription of 3D MR Spectroscopic Imaging of the Brain PDF Poster E. Ozhinsky, J. Ellison, T. Luks, J. Lupo, Y. Li University of California San Francisco, San Francisco, United States Impact: This study demonstrates the feasibility of a machine learning-based automated prescription of 3D MRSI acquisition of the brain. This would help solve a major challenge of incorporating metabolic imaging into the routine clinical care of patients with brain tumors.
		5243. Quantitative validation of 7T MRSI in gliomas by targeted mass spectrometry PDF Poster S. Acharya, C. Cadrien, S. Huskic, P. Lazen, A. Azgin, C. Brenner, J. Furtner, B. Kiesel, L. Koerner, M. Preusser, T. Roetzer-Pejrimovsky, G. Köllensperger, S. Trattnig, W. Bogner, G. Widhalm, K. Rössler, G. Hangel High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, Vienna, Austria Impact: Using 7T MRSI maps to sample metabolic hotspots allowed us to compare MRSI findings with histological and quantitative features. We demonstrated that combining MRSI and MS offers a more comprehensive metabolic profile of gliomas with room for improvement.
		5244. Improved Nuisance Signal Removal for 3D 1H-MRSI Using Physics-Driven Subspace Learning PDF Poster X. Li, Z. Wang, Y. Wang, F. Lam University of Illinois at Urbana-Champaign, Urbana, United States Impact: The proposed method can potentially accelerate the data acquisition time and improve the nuisance removal outcome in 3D ¹H-MRSI without lipid suppression.
		5245. Optimization of a mixed block and event-related fMRS acquisition protocol for a working-memory task at 7T PDF Poster D. Cocking, R. Elson, K. Dyke, M. Katshu, C. Danielmeier, A. Berrington University of Nottingham, Nottingham, United Kingdom Impact: This study validates that TE=80ms semi-LASER improves GABA and Glu detection and offers a mixed-design fMRS protocol for cognitive studies. This opens the possibility to study temporal dynamics of glutamate during a working memory task.
		5246. Deuterium metabolic spectroscopy and imaging in human at 5T MR system: preliminary study PDF Poster L. Zou, G. Yang, Q. Wan, X. Yang, H. Zheng, Y. Li, X. Liu Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China Impact: This is the first deuterium MRS/MRSI work at a human 5T system, using a home-built multi-nuclei imaging platform. The feasibility of deuterium MRS/MRSI at 5T for clinical applications was successfully validated through in vivo human studies.
		5247. In Vivo Detection of Glutamate, Glutamine, and Glutathione at 3 T via Difference Editing of Aspartyl Resonances PDF Poster L. An, S. Hong, T. Turon, A. Pavletic, C. Johnson, J. Shen National Institutes of Health, Bethesda, United States Impact: Time-course spectra following oral administration of [U-¹³C]glucose demonstrate, for the first time, the feasibility of measuring ¹³C turnover of spectrally resolved glutamate at 3 T with the high sensitivity and spatial resolution of proton MRS.

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