ISMRM25 - Advancing Non-Contrast MRI: Blood-Flow, CEST, & Magnetization Transfer

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Advancing Non-Contrast MRI: Blood-Flow, CEST, & Magnetization Transfer

Traditional Poster

Monday, 12 May 2025

Building: Room: Exhibition Hall

08:15 - 09:15

Session Number: T-14

No CME/CE Credit

		4760. Comparison of Fat Correction Methods in CEST Imaging: A Phantom Study at 3 T PDF Poster N. Kempa, P. Boyd, P. Menshchikov, M. Ladd, P. Bachert, A. Korzowski German Cancer Research Centre (DKFZ), Heidelberg, Germany Impact: We compared and ranked existing fat correction methods for CEST imaging in a phantom study, representing an important milestone towards application in vivo. Prospectively, these findings hold great promises for making full use of all CEST contrasts in lipid-containing tissues.
		4761. Investigating spatial distribution of metabolite diffusion using diffusion-weighted chemical exchange saturation transfer PDF Poster View Presentation Video Y. Jung, J. Park, S-G Kim, S-H Park Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of Impact: Analysis on amide-weighted ADC showed comparable results to findings in DW-MRS studies with more spatial information. This suggests that DW-CEST has the potential to examine metabolite diffusion with better spatial resolution than DW-MRS.
		4762. Swin-Transformer based B0 inhomogeneity correction for GluCEST and NOE MRI PDF Poster Y. Li, P. Jacobs, D. Kumar, A. Swain, R. P. R. Nanga, J. Detre, R. Reddy, Z. Wang University of Maryland School of Medicine, Baltimore, United States Impact: This success of the proposed method suggests that the Swin Transformer could potentially serve as a general model for B0 correction across various metabolites in a single model if sufficient data is available.
		4763. CEST and Z-spectrum analysis proton (ZAP) in the liver PDF Poster Y. Kuwatsuru, V. Malis, Y. Kassai, C. Sirlin, M. Miyazaki University of California, San Diego, La Jolla, United States Impact: This study demonstrates the potential of multiparametric CEST and ZAP imaging that non-invasively identifed molecular abnormalities in the liver, providing critical insights into iron and fat deposition, which could enhance the diagnosis and management of liver diseases.
		4764. VO-CEST: Variable-Optimized CEST using optimized adiabatic RF design on 3T PDF Poster Z. Xie, Z. Zhou, P. Hu School of Biomedical Engineering, Shanghaitech Unversity, Shanghai, China, Shanghai, China Impact: A novel protocol that focusing on optimizing the RF waveform and bandwidth is proposed and can be broadly used in tasks involving adiabatic pulses.
		4765. Noninvasive Evaluation of Cerebrospinal Fluid Protein Concentration Using Amide Proton Transfer-weighted Imaging PDF Poster T. Kawasaki, K. K. Tha, M. Yoneyama, K. Ishizaka, K. Kudo Hokkaido University Hospital, Sapporo, Japan Impact: APTw imaging shows potential as a noninvasive tool to estimate protein concentration in CSF, offering a safer alternative to lumbar puncture for assessing CSF proteins.
		4766. Amide Proton Transfer-weighted MRI in Predicting Muscle invasion and Histologic Grade of Bladder Cancer PDF Poster Y. Ma, H. Xu, X. Ning, H. Liu, Y. Chen, M. Cui, X. Bai, D. Zheng, H. Wang First Medical Center of Chinese PLA General Hospital, Beijing, China Impact: This finding suggests that the preoperative application of APT for predicting the grade of bladder cancer may provide a more comprehensive evaluation scheme for personalized treatment of bladder cancer patients.
		4767. Unsupervised AnomalyCEST: Unsupervised anomaly detection using CEST MRI of brain at 7T A. Swain, P. Jacobs, A. Mathur, R. Reddy University of Pennsylvania, Philadelphia, United States Impact: Traditional CEST MRI methods require large sample sizes and complex fitting techniques to compare healthy individuals with those having pathology. Unsupervised anomaly detection of Z-spectra will enable the detection of anomalous voxels linked to pathology at an individual level.
		4768. Enzyme-Mediated Nanostructure Transition for Enhanced CEST MRI in Triple-Negative Breast Cancer PDF Poster Z. Yu, Q. Wen, Y. Zhang, Y. Yuan Uinversity of Science and Technology of China, Hefei, Anhui, China Impact: This enzyme-mediated nanostructure transition strategy specifically enhances CEST MRI in tumor cells, facilitating the development of more effective diagnostic and therapeutic probes for various diseases.
		4769. Exploring the Origins of the APTw Contrast in the Human Brain Using a Physically Interpretable Machine Learning Model PDF Poster F. Kroh, P. S. Boyd, N. von Knebel Doeberitz, H-P Schlemmer, M. E. Ladd, D. Paech, A. Korzowski German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: This work introduces a physically interpretable model that decodes the APTw contrast mechanisms in the human brain, analyzing influences of amide and rNOE contrast. The model provides new insights into factors that impact APTw imaging, potentially enhancing the clinical interpretation.
		4770. Development and Evaluation of an Automated Pipeline for ASL Scan Planning and Labeling Plane Positioning PDF Poster Z. Zhang, H. Han, H. Hao, Q. Wei, X. Wang, X. Meng, N. Wei, W. Zhu, Y. Suo, S. Chen, J. Jing Beijing Tiantan Hospital, Capital Medical University, Beijing, China Impact: The proposed automated ASL planning pipeline achieves both standardized brain orientation and optimized labeling plane positioning, potentially reducing labeling inefficiencies on tortuous arteries and minimizing false-positive hypoperfusion cases.
		4771. Repeatability of Absolute vs Relative Cerebral Blood Flow and Arterial Transit Time for Single-Delay and Multi-Delay Arterial Spin Labelling PDF Poster A. Fothergill, D. Higgins, O. Thomas, D. Coope, I. Djoukhadar, L. Parkes The University of Manchester, Manchester, United Kingdom Impact: Our repeatability study shows relative CBF has much lower CoV than absolute CBF and therefore relative CBF may be more useful for longitudinal studies. MD-ASL acquisition is preferable, giving lower CoVs for CBF and additional ATT with good repeatability.
		4772. Multi-center and multi-vendor reproducibility of PCASL data on 3T MRI scanners PDF Poster R. Echeverria-Chasco, L. Garcia-Ruiz, M. Aastrup, V. Aramendia-Vidaurreta, M. Bozzetto, P. Brambilla, E. Hansen, L. Micu, J. M. Mora-Gutierrez, S. Pasini, A. Raj, S. Ringgaard, A. Strittmatter, M. Taso, I. Urdea, T. Vendelboe, M. Vidorreta, G. Villa, N. H. Buus, N. Garcia-Fernandez, M. Trillini, D. C. Alsop, S. T. Francis, L-M Itu, C. Laustsen, F. G. Zoellner, A. Caroli, M. A. Fernandez-Seara Clinica Universidad de Navarra, Pamplona, Spain Impact: Harmonized PCASL sequence for renal perfusion measurements shows promise for reliable multi-center and multi-vendor studies
		4773. Blurring-free 3D perfusion and arterial blood T2 mapping using partition encoding reordered GRASE (PER-GRASE) ASL at 5T PDF Poster J. Xu, Q. Wei, Q. Pang, W. Fang, X-Y Zhang, H. Li, Z. Chen, H. Wang, D. Wang, P. Hu, F. Yan, X. Shao Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, ShangHai, China Impact: We proposed a PER-GRASE ASL technique for blurring-free perfusion and arterial blood T2 mapping with full-brain coverage at 5T, which has the potential to be adapted for measuring neurovascular function such as brain oxygenation and BBB function in clinical studies.
		4774. MUSIC: Multi-Coil Unified Sparsity Regularization Using Inter-Slice Correlation for ASL MRI Denoising PDF Poster H. Liu, B. Li, Y. Li, M. Taso, M. Tisdall, Y. Chang, J. Detre, Z. Wang University of Maryland School of Medicine, Baltimore, United States Impact: MUSIC enables more accurate perfusion imaging, potentially benefiting neuroimaging diagnostics and encouraging further research into SNR enhancement methods that refine non-invasive imaging across clinical and research settings.
		4775. Comparing One-Stage and Two-Stage Model Fitting Approaches in Multi-TE ASL for Blood-Brain Barrier Permeability Assessment PDF Poster A. Mahroo, K. Eickel, M. Günther Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany Impact: This study shows that two-stage approaches, using different models in each stage, risk error propagation due to parameter cross-dependence. These insights are essential for developing more accurate, clinically applicable BBB imaging models that improve parameter reliability.
		4776. Improving Pseudo-continuous ASL Efficiency at 7 Tesla Using Gapless Multi-echo EPI PDF Poster Y. Chang, L. Craven-Brightman, W-c Lo, J. Stockmann, M. Vidorreta, J. Kufer, M. Taso, J. Detre, M. Juttukonda Siemens Medical Solutions USA Inc., Malvern, United States Impact: The gapless multi-echo EPI readout, along with the proposed processing method, significantly improves the overall efficiency of arterial spin labeling at 7 Tesla, which can make ASL faster, more robust, and more accessible at ultra-high fields.
		4777. 2D real-time magnetic resonance imaging to characterize myocardial oxygenation during breathing maneuvers PDF Poster L. Romanin, J. Banus, C. Roy, J-B Ledoux, A. Mackowiak, R. van Heeswijk, J. Richiardi, S. Rapacchi, M. Stuber Siemens Healthineers International AG, Lausanne, Switzerland Impact: This study advances oxygen-sensitive CMR by introducing real-time 2D radial imaging with automated processing to continuously capture myocardial oxygenation, extending the wealth of information and the feasibility of this needle-free imaging for cardiovascular diseases.
		4778. Simultaneous DCE-DSC evaluation with 3D stack-of-spiral FLASH readout PDF Poster Z. Xu, X. Liu, X. Lin, S. Yu, H. Sun, R. Li, H. Chen Center for Biomedical Imaging Research, Tsinghua University, Beijing, China Impact: DFA-ME enables whole-brain dynamic T1 and T2* mapping at 2.0×2.0×6.0 mm³ spatial resolution and a temporal resolution of 2.1 s, allowing simultaneous and accurate evaluation of DCE and DSC with a single-dose contrast injection.
		4779. Fourier Informed Native Deblurring (FIND): A Robust Solution for Blurring in pseudo-Continuous Arterial Spin Labeling (pCASL) MRI PDF Poster M. Zucchelli, O. Dipasquale, C. Papageorgakis, V. Prevost, E. Poirion, J. Savatovsky, B. Triare, S. Casagranda Olea Medical, La Ciotat, France Impact: FIND improves pCASL MRI image quality, enabling a more accurate assessment of brain pathologies and advancing clinical imaging applications.

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