ISMRM25 - Diffusion Analysis & Applications

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Diffusion Analysis & Applications

Traditional Poster

Monday, 12 May 2025

Building: Room: Exhibition Hall

09:15 - 10:15

Session Number: T-15

No CME/CE Credit

		4780. The comprehensive Subcortical Atlas of the Human Brain (“SAHB”) derived from high-resolution multimodal MRI at 7T. K. Saleem, A. Avram, D. Glen, C. Yen, P. Basser Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, United States Impact: Tracing and validating subcortical regions in 3D are imperative for neurosurgical planning for DBS, fMRI studies, cross-species comparison, and establishing brain structure-function relationships.
		4781. Streamline-Based Analysis: A novel framework for tractogram-driven streamline-wise statistical analysis PDF Poster S. Zanoni, J. Lv, R. Smith, F. Calamante The University of Sydney, Sydney, Australia Impact: The introduced SBA method offers an unprecedented streamline-wise specificity and an unexplored perspective for investigating brain differences, where the pathways of the streamlines effectively shape the insights gained from imaging data across different modalities.
		4782. Free-Water Elimination (FWE) reduces partial volume effects from cerebrospinal fluid in DTI of the human spinal cord PDF Poster A. Blombäck, M. Ljungberg, H. Olsson, K. Lagerstrand Institute of Clinical sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Impact: Findings display reduced partial volume effects in diffusion tensor imaging of spinal cord with the use of free-water elimination. Potentially facilitating more accurate assessment of microstructural changes and surveillance of patients with spinal cord affection.
		4783. Denoising diffusion MRI data: Principal components meet non-local block-matching PDF Poster V. Campos, D. Szczupak, T. Santini, A. Silva, A. Foi, M. Vieira, C. Baron University of PIttsburgh, Pittsburgh, United States Impact: The innovative BM4PC reduces noise in diffusion-weighted images, enabling diagnostic capabilities and sensitivity to tissue microstructure and degeneration. It can be applied across diverse acquisition types and datasets (in vivo and ex vivo), from Cartesian encoding to advanced spiral techniques.
		4784. Architectural Disruption Signature: Region-specific MRI Biomarkers in Cuprizone-induced Demyelination for Alzheimer’s Disease PDF Poster Z. Liu, P. Eddula, M. Jafry, J. Chen, N. Wang UT Southwestern Medical Center, Dallas, United States Impact: This comprehensive multi-modal MRI analysis provides insight into region-specific pathological changes in the cuprizone model, particularly in isocortex and hippocampal areas. These findings enhance our understanding of demyelination processes and could guide the development of targeted therapeutic strategies for AD.
		4785. GPU-accelerated Diffusion MRI Tractography in DIPY PDF Poster J. Kruper, M. Bisson, J. Romero, M. Fatica, A. Rokem University of Washington, Seattle, United States Impact: We introduce GPU-accelerated tractography that achieves up to 50x faster performance per GPU. Through integration with the Diffusion Imaging in Python (DIPY) library, it enables large-scale tractography studies that would not be possible otherwise.
		4786. A Deep Diffusion Model Approach for Diffusion MRI White Matter Fiber Tractography PDF Poster Y. Li, W. Zhang, X. Zhu, Y. Wu, Y. Rathi, L. O’Donnell, F. Zhang University of Electronic Science and Technology of China, Chengdu, China Impact: The proposed diffusion model-based method, integrating local neighborhood information and sequential dependencies, directly achieves local fiber orientation estimation and tractography. Tested on in silico and in vivo datasets, we demonstrate competitive performance against current methods.
		4787. Impacts of diffusion MRI spatial resolutionon on the short-range association fiber reconstruction and connectivity estimation PDF Poster J. Zheng, C. Yang, W. Zhong, Z. Wang, H. Li, Z. Li, M. Liu, H. Yang, X. Cao, C. Liao, D. Salat, S. Huang, Q. Tian Tsinghua University, Beijing, China Impact: This study demonstrates the poor reconstruction result of SAFs at low resolution, emphasizing the need for high-resolution diffusion imaging for accurately SAF modeling. The gSlider protocol presented in the study could be an ideal choice for SAFs research.
		4788. Improving Specificity in Fixel-Based Analysis H. Rafipoor, S. Jbabdi, L. Concha, M. Cottaar University of Oxford, Oxford, United Kingdom Impact: This study improves the specificity of fixel-based analysis in diffusion MRI, allowing for more accurate detection of fiber-specific microstructural changes. It paves the way for tract-specific metrics that could enhance the diagnosis of neurological conditions with selective fibre degeneration.
		4789. Measuring Perfusion in normal and pathological placentas using an advanced IVIM method. PDF Poster N. Elsaid, H. Tagare, J. Ngwa, K. Kapse, C. Limperopoulos, N. Andescavage Children’s National Health System, Washington, United States Impact: To better understand and analyze in-vivo placental perfusion, we developed a novel method based on mixture-prior for intravoxel incoherent motion (IVIM). It shows an improved ability to distinguish between control and growth-restricted placentas.
		4790. Diffusion Tensor Imaging as a Methodology for Optic Nerve Evaluation PDF Poster K. Clarke, Z. Ben Youss, P. Filipiak, A. Verdone Sanchez, M. Bruno, V. Dedania, K. Chan, S. Baete NYU Langone Health , New York, United States Impact: Non-invasive optic nerve screening with DTI may provide additional insight into the optic nerve microstructure making it a potential avenue to identify optic neuropathies, such as glaucoma.
		4791. Linking brain and eye fluid dynamics: Multi-b-value diffusion derived interstitial fluid volume relates to tear fluid AQP5 levels PDF Poster B. van den Heuvel, N. van de Sande, G. Drenthen, W. Backes, M. Gijs, J. Jansen, M. van der Thiel Maastricht University Medical Center, Maastricht, Netherlands Impact: By identifying a relationship between tear fluid AQP5 concentration and cerebral interstitial fluid volume, this study suggests that eye and brain fluid dynamics are linked, supporting the hypothesized link between ocular and brain (glymphatic) clearance in humans.
		4792. Creatinine accumulation may lead to increased interstitial fluid in patients with chronic kidney disease W. Yang, L. Song, M. Li, X. Bai, B. Xu, H. Wang, Z. Wang Department of Radiology, Beijing Friendship Hospital, Capital Medical University , Beijing, China Impact: A novel approach to measure ISF shows the potential for detecting brain glymphatic system function, which provides unique insights into the pathological mechanisms underlying cognitive decline in CKD patients.
		4793. Towards Data-Driven Tractography for Surgical Planning PDF Poster M. Muir, K. Noll, V. Kumar, S. Prabhu, R. Stafford, B. Taylor MD Anderson Cancer Center, Houston, United States Impact: These findings outline a data-driven, patient-specific approach for using tractography to localize the language-essential regions surrounding the tumor.
		4794. Higher Insulin Resistance is Associated with Lower Myelin Content in Women PDF Poster N. Zhang, Z. Gong, J. Bae, A. Guo, N. Fox, A. De Rouen, J. Laporte, M. Bouhrara National Institutes of Health, Baltimore, United States Impact: This research highlights the connection between metabolic conditions and white matter integrity in women. It also underscores that MWF offers a more sensitive measure of microstructural differences as compared to FA.
		4795. White Matter Integrity and Asymmetry Alterations in Young Children with Autism Spectrum Disorder: An Automated Fiber Quantification Study D. Luo, C. Zhao, L. Nie, Y. Yin, X. Liu, H. Yu, F. Wang, H. Chen, H. Liu Department of Radiology, Affiliated Hospital of Zunyi Medical University, Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education Institutions, 149 Dalian Road, Huichuan District, Zunyi, Guizhou 563003, P.R. China, Zunyi, China Impact: This study identifies WM biomarkers linked to social and repetitive behaviors in ASD, guiding early diagnosis and intervention. These findings pave the way for research on targeted treatments addressing specific neurodevelopmental delays in ASD.
		4796. DTI-ALPS mapping: A Novel Method for Analyzing the Glymphatic System in the Brain PDF Poster X. Zhang, X. Fan, K. Yu, Q. Li, X. Li, Y. Qi, L. Chen, Z. Wei, G. Lu, H. Chen, L. Hu, G. Cheng, N. Zhang Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China Impact: This study represents a pioneering effort by introducing a white matter DTI-ALPS mapping technique. This innovative approach significantly enhances the detection of differences associated with cognitive decline and offers a more comprehensive perspective for advancing our understanding of neurodegenerative processes.
		4797. Cardiac Magnetic Resonance T1 Mapping Combined with Myocardial Diffusion Technique for Evaluating Fibrosis in Hypertensive Heart Disease (HHD) X. Ruan, X. Yue Ningxia Hui Autonomous Region People's Hospital, Ningxia,yinchuan, China Impact: This study provides a quantitative assessment of myocardial fibrosis in HHD patients using T1 mapping combined with MoCo cDWI, supporting fibrosis diagnosis.
		4798. Increased Brain white matter extracellular free-water is associated with memory function in ESRD patients PDF Poster H. J. Chen, J. Qiu, Y. Qi, Y. Guo, W. Huang, H. Qin, F. Wu, F. Chen Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China Impact: This study highlights a potential link between elevated extracellular free water in white matter and memory decline in hemodialysis patients, suggesting neuroinflammation or microvascular impairment. These findings could inform future research on neuroprotective strategies in dialysis patients.
		4799. Comparison of MoCo-MPG schemes and readout sequences (EPI/TSE) towards robust myocardial IVIM-DWI PDF Poster Y. Goto, M. Nagao, M. Yoneyama, G. Gilbert, J. Peeters, I. Shiina, Y. Katsumata, K. Kodaira, Y. Hamatani, M. Kato, S. Sakai Tokyo Women's Medical University Hospital, Tokyo, Japan Impact: Cardiac IVIM may play an important role in the evaluation of various cardiac diseases.Our results suggest that M2-null EPI-DWI using deep learning-constrained compressed SENSE with high reduction factor may be a suitable method for robust myocardial IVIM imaging.

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