ISMRM25 - Peripheral Nerve & Pharmacology

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Peripheral Nerve & Pharmacology

Traditional Poster

Monday, 12 May 2025

Building: Room: Exhibition Hall

17:00 - 18:00

Session Number: T-23

No CME/CE Credit

		4934. Multi-site Harmonization of Diffusion Tensor Image for Nerves of the Upper Extremity PDF Poster P. Wang, X. Ma, K. Lombardi, Y. Chen, I. Manzanera Esteve, S. Christopher, M. Mahan, W. Thayer, R. Dortch Barrow Neurological Institute, Phoenix, United States Impact: The study established an imaging benchmark for patients with peripheral nerve damage following trauma, potentially enabling cross-site and cross-vendor data comparisons.
		4935. MR-Neurography with a Fully Automated Nerve Segmentation Workflow PDF Poster A. Holl, S. Tashakori, B. Wilhelm-Feldbusch, M. Reisert, A. Rau, M. Zaitsev, S. Littin Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Freiburg, Germany Impact: The developed workflow enhances clinical MR-Neurography by improving image quality, automating the identification and segmentation of nerves, rendering diagnoses more precise and efficient, and allowing cross-patient application with both healthy and pathological peripheral nerves.
		4936. Assessing the relationship between glutamate, GABA, and synaptic density in healthy subjects after ketamine administration PDF Poster C. Rua, C. Agnorelli, K. Ahmad, J. Peill, G. Sawicka, M. Wall, P. Matthews, E. Rabiner, D. Nutt, D. Erritzoe Perceptive, London, United Kingdom Impact: This study investigates the link between Glutamate and GABA levels, measured by 1H MRS, and synaptic density, measured by [11C]UCB-J PET, in healthy individuals within a week after ketamine administration, exploring neuroplasticity effects.
		4937. Associations of MRI-Derived Glymphatic System Impairment with White Matter Microstructure Damage in Trigeminal Neuralgia PDF Poster J. Jiang, J. wang, p. zhang, k. ai, f. jia, z. wang, w. huang, j. zhang Lanzhou University Second Hospital, lanzhou, China Impact: This research represents a pioneering investigation of cerebral glymphatic function and white matter microstructure in TN patients utilizing both DTI-ALPS index and NODDI, as well as examining their associations with pain severity and psychological well-being scores.
		4938. A Combined Radiomics and Anatomical Features Model Enhances MRI-Based Recognition of Symptomatic Nerves in Primary Trigeminal Neuralgia h. Li, S. Li, Y. Yang, S. He, X. Xu, h. Yang North Sichuan Medical College, Nanchong, China Impact: This study has greatly improved the accuracy of radiologists in diagnosing the disease, which is conducive to the early detection and treatment of the disease; It also provides the basis for the study of the pathophysiological mechanism of PTN.
		4939. fMRI Finger Representations in the Primary Somatosensory Cortex at 3T – Parallel Imaging vs. Partial Fourier Techniques for the EPI Sequence PDF Poster C. Fellner, M. Ruewe, S. Klein, S. Frank, A. Eigenberger, A. Anker, D. Deuter, M. Knott, K. Rosengarth University Hospital Regensburg, Regensburg, Germany Impact: fMRI with parallel imaging instead of partial Fourier, a voxel size of (1.5mm)³ and 200 measurements seems to be a reliable technique at 3T for mapping finger representations in somatosensory cortex, which is also well suited for application in patients.
		4940. The combination of MR neurography at 3T and 7T for the assessment of nerve damage in peripheral neuropathies PDF Poster J. Jende, K. Zhang, C. Mooshage, T. Platt, V. Sturm, C. Neelsen, J. Oppold, M. Bendszus, H. Schlemmer, M. Ladd, F. Kurz German Cancer Research Center, Heidelberg, Germany Impact: The results indicate that polyneuropathies are associated with a fusion of nerve fascicles which results in an increase in fascicular diameter and a reduced number of fascicles. This is related to a decline in quantitative parameters that codify nerve function.
		4941. Optimizing Contrast-enhanced Magnetic Resonance Neurography of the Brachial Plexus by Delayed Scanning J. Xu, P. Sun, X. Kong Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Impact: Help obtain better brachial plexus ceMRN images. May promote new scanning protocols for improving ceMRN image quality.
		4942. In-vivo 7T 1H-MRS reveals different time courses of brain acetone and β-hydroxybutyrate after oral ketone monoester administration PDF Poster S. Alcicek, D. A. Bazer, L. Blair, İ. Özdemir, Z. Shams, J. Wijnen, V. Yedavalli, M. Holdhoff, J. Laterra, K. C. Schreck, D. O. Kamson, G. Oeltzschner The Johns Hopkins University School of Medicine, Baltimore, United States Impact: Ketone monoester supplementation is a complementary therapeutic strategy for many diseases, but data on ketone dynamics in the brain are limited. High-field MRS can be used to investigate pharmacokinetics of ketones in healthy tissue as well as in tumors.
		4943. Diffusion MRI as A Biomarker for Monitoring Recovery After Surgical Repair of Traumatic Peripheral Nerve Injuries: A Case-Series Study I. Manzanera Esteve, S. Chaker, R. Torres-Guzman, Y. Jun, B. Gutama, R. Cornely, P. Wang, S. Christopher, G. Perdikis, R. Dortch, W. Thayer Vanderbilt University Medical Center, Nashville, United States Impact: This study provides insight into the evolution of FA values along the nerve during recovery, providing for an automated and consistent approach to identify cases that require surgical inventions.
		4944. Intrinsic Functional Connectivity as a Moderator and Consequence of Cocaine Self-Administration in Rats PDF Poster L. Hsu, D. Cerri, S-H Lee, T. Shnitko, R. Carelli, Y-Y Shih University of North Carolina at Chapel Hill, Chapel Hill, United States Impact: This study provides new insights into how brain network connectivity is both altered by and predictive of cocaine use, suggesting new circuit-based treatment strategies.
		4945. Mathematical model of sciatic nerve regeneration: FA changes along the distal section relate to behavioral recovery I. Manzanera Esteve, L. Yan, H. Karagoz, R. Torres-Guzman, B. Gutama, S. Chaker, R. Cornely, B. Savitz, A. James, E. Abott, N. Alter, A. Reddy, P. Wang, S. Christopher, R. Dortch, W. Thayer Vanderbilt University Medical Center, Nashville, United States Impact: FA close to the injury site shows great potential as a reliable biomarker for assessing nerve injury and postoperative recovery.
		4946. Inter-Site Reproducibility of Peripheral Nerve DTI in the Upper Extremities PDF Poster K. S. Christopher, I. Manzanera Esteve, P. Wang, M. Battista, L. Ott, R. Dortch Barrow Neurological Institute, Phoenix, United States Impact: Peripheral nerve trauma results in disability. Even after surgery, it can take months for electro-diagnostics to report on success/recovery. FA from DTI can report on injury-severity and failed surgeries. To advance for clinical readiness, consistency across multiple sites is required.
		4947. Test-Retest Reliability of Median and Ulnar Nerve DTI: Comparison on Local PCA and Patch2self Denoising Methods PDF Poster K. S. Christopher, L. Ott, R. Dortch Barrow Neurological Institute, Phoenix, United States Impact: Peripheral nerve injuries result in loss of sensorimotor function. FA from DTI can report on injury severity, but DTI requires high spatial resolution which results in low SNR data. Effective denoising is required to improve the quality of the data.
		4948. Neuroanatomical Signatures of Fluctuation Amplitude and Statistical Bias in Resting-State fMRI PDF Poster J. Autio, T. Hayashi RIKEN, Kobe, Japan Impact: Clarifying how brain input-output structures affect fMRI amplitude is crucial for advancing image processing and improving the interpretation of functional connectivity metrics.
		4949. Integrative neurovascular coupling and neurotransmitter analyses in pediatric anisometropic and visual deprivation amblyopia PDF Poster B. Wen, X. Zhang, Z. Liu, J. Sun, M. Wang, Y. Zhang, J. Cheng the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Impact: Children with anisometropic amblyopia and visual deprivation amblyopia exhibited neurovascular coupling dysfunction with neurovascular coupling effects linked to altered receptors and transporters, thus providing information for developing targeted neural therapies for amblyopia.
		4950. Stability of Local Coherence at Rest Indicates Dopamine Modulation Underlying Creativity Q. Cai, K. Chen East China Normal University, Shanghai, China Impact: This study is the first to provide empirical support for the dopamine theory of creativity, revealing how local coherence modulated by dopamine influences creativity. For clinical applications, ReCo may serve as a sensitive, specific and reproducible proxy for dopamine receptors/transporters.
		4951. Spectrally Edited Glutamate Associated with Autism Traits PDF Poster M. Saleh, L. Bloy, L. Blaskey, T. Roberts The Children's Hospital of Philadelphia, Philadelphia, United States Impact: Brain glutamate plays a role in language comprehension, which differs in ASD. This study found that MRS-derived glutamate levels are associated with SRS scores, implying that glutamate is a potential marker for communication deficits in ASD.
		4952. Memantine Treatment and Its Impact on Brain Glutathione Levels and Social Function in Youth with Autism Spectrum Disorder: An In Vivo MRS Study PDF Poster A. Gonenc, M. O'Connor, A. Ceranoglu, J. Wozniak, J. Gagan Massachusetts General Hospital, Boston, United States Impact: Memantine’s impact on GSH levels and social function in ASD suggests new therapeutic avenues to address oxidative stress-related impairments. These findings offer preliminary evidence that could guide future research and therapeutic strategies targeting ASD’s core social deficits.
		4953. The Efficacy of Three-Dimensional Magnetic Resonance Elastography in Predicting Intraocular Pressure PDF Poster G. Zheng, S. Yu, G. Haonan Shengjing Hospital, China Medical University, Shenyang, China Impact: 3D-MRE provides a simple and non-invasive clinical method for IOP prediction independent of CCT and corneal curvature, and may be used to serve glaucoma patients and people undergone corneal surgery, etc.