ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Traditional Poster

Psychiatric Disorders & Sytemic Pathology Affecting Normal Appearing Brain

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Psychiatric Disorders & Sytemic Pathology Affecting Normal Appearing Brain
Traditional Poster
Tuesday, 13 May 2025
Building:   Room: Exhibition Hall
14:30 -  15:30
Session Number: T-25
No CME/CE Credit

    5069. WITHDRAWN
  5070. The impact of deep learning based image reconstruction on the quantification of DTI for assessing the severity of depression
Y. Cui, S. Dong, Y. Zhang, J. Dai, S. Liu, Y. Xiao
Second Affiliated Hospital of Naval Medical University, Shanghai, China
Impact: DLR can significantly increase the SNR of DTI images which likely improve the quantification accuracy for better assessing depression severity. Therefore, the application of DLR would be beneficial for depression assessment and management.   
  5071. Mean Apparent Propagator Magnetic Resonance Imaging Study of White Matter Microstructural Changes in Neuropsychiatric Lupus
z. li, h. liu, y. jiang
The First Hospital of China Medical University, 辽宁, China
Impact: Application of mean apparent propagator MRI for patients with neuropsychiatric systemic lupus erythematosus may help identify early biomarkers of the disease, which is crucial for timely intervention and treatment strategies.
  5072. Common and specific gray matter abnormalities and epicenter distribution across major psychiatric disorders
P. Zhu, K. Qin, W. Chen
Department of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Impact: Due to the highly overlapping symptoms of MDD,BD and SZ, there are often misdiagnoses. Therefore, this study explores the potential structural change patterns of the three diseases through structural similarities and differences, and provides reliable diagnostic basis for the clinic.
  5073. Neurofluid and Microstructural Evaluation by Time-Dependent Diffusion Analysis and White Matter Parameters in Obstructive Sleep Apnea
T. Taoka, K. Iwamoto, S. Miyata, R. Ito, R. Nakamichi, T. Nakane, H. Fujishiro, K. Ichikawa, A. Kamiunten, N. Ichinose, M. Ikeda, S. Naganawa
Nagoya University, Nagoya, Japan
Impact: ΔADC could serve as an indicator of brain microstructural changes linked to respiratory function, with implications for evaluating neurofluid dynamics.
  5074. Temporoparietal structural-functional coupling abnormalities in drug-naïve first-episode major depressive disorder
Q. Zhang, A. Zhang, G. Kemp, Y. Zhao, Q. Gong
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China
Impact: Our findings revealed disrupted topology-related interplay between structural and functional connectivity in temporoparietal regions in MDD, advancing understanding of MDD-related multimodal network abnormalities and highlighting the role of right hippocampal coupling alterations in identifying the anxious depression subtype.
    5075. WITHDRAWN
  5076. Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes
B. Wen, Q. Tao, Y. Tian, W. Shi, Z. Liu, J. Sun, Y. Zhang, J. Cheng, S. Han
the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: Two subtypes manifest opposite gray matter morphological abnormalities. Subtype exhibit divergent structural covariance network-informed disease epicenters. Gray matter morphological abnormalities of subtypes exhibit distinct associations with neurotransmitter receptors/transporters. Novel insights are offered into nosology and heterogeneous nature of OCD.
  5077. Bariatric Surgery Alters Brain Glymphatic Function in Obese Patients: A DTI-ALPS Study
J. Duan, Y. Liao, P. Wu, J. Peng, P. Rong
The Third Xiangya Hospital of Central South University, Changsha, China
Impact:

This research suggests bariatric surgery can alter the brain's glymphatic system, highlighting its potential influence on cognitive health and opening avenues for further exploration of obesity-related neurological impacts.

  5078. Frequency-Dependent and Temporal Variability of Low-Frequency Fluctuations in Primary Sjögren's Syndrome Patients
C. Hu, L. Wang, P. Wei, Y. Shang, X. Zhang, X. Du, H. Cao, C. Gao, X. Ge, Z. Ding, Z. Han, J. Huang
Hangzhou First People's Hospital, Hangzhou, China
Impact: This study reveals that ALFF indicators demonstrate aberrant alterations in pSS, exhibiting characteristics of both frequency dependence and temporal variability, complementing traditional metrics and suggesting that ALFF could serve as a novel tool for investigating the neurological underpinnings of pSS.
  5079. Application of Zoomit-DTI in Assessing Fetal Brain White Matter Development in Pregnancies Complicated by Maternal Diabetes
Q. Zhu, M. Liu, L. Deng
ZheJiang SirRunRun Hospital, Hangzhou, China
Impact: This study reveals the microstructural differences in fetal brain white matter development in pregnant women with GDM. Zoomit - DTI may be helpful for the early diagnosis and intervention of the neurodevelopmental risks of fetuses in pregnant women with GDM.
  5080. Cortical and subcortical gray matter bases of sleep disturbance in patients with end-stage renal disease undergoing hemodialysis
Y. Jiang, Z. Zhang, Y. Miao, J. Wu
Zhongshan Hospital Affiliated to Dalian University, Dalian, China
Impact: Cortical and subcortical gray matter abnormalities are associated with sleep quality in HD patients, with a more widespread pattern observed in patients with SD. Our findings highlight the importance of distinguishing HD patient subgroups based on sleep quality.
  5081. MRS Insights into Cerebellar Alterations and Motor Variations in Welders Exposed to Manganese
J. George, B. Bozymski, G. Nossa, C. Mizimakoski, C. Lee, J. Park, R. Harold, D. Foti, U. Dydak
Purdue University, West Lafayette, United States
Impact: This study examines the cerebellum’s response to Mn overexposure, linking elevated Mn to disrupted glutamatergic signaling and potential oxidative stress. Findings could support stricter occupational health guidelines and further research on Mn’s effects on motor control and neurodegenerative risks.
  5082. Cerebral Hypoperfusion and Vascular Impairment in Long COVID Patients with Cognitive Symptoms
S. Cataldo, M. Belzunce
ECyT, UNSAM, Buenos Aires, Argentina
Impact:  Our results indicate that cerebral hypoperfusion may serve as a biomarker to evaluate new treatments for long COVID, reinforcing the hypothesis that vascular dysfunction underlies its cognitive symptoms. This could improve diagnostic accuracy and guide targeted interventions.
  5083. Asymmetric impairment of hippocampus in patients with type 2 diabetes mellitus related with cognitive function
P. Pan, J. Gao, A. Kai, X. Lei, X. Zhang
Shaanxi Provincial People's Hospital, Xi'an, China
Impact: Hippocampal injury in patients with T2DM is asymmetry. H-PVS and hippocampal CBF are expected to be imaging markers for identifying general cognitive dysfunction. This may provide clinicians with important information for planning treatment strategies and assessing prognosis in T2DM patients.
  5084. Higher CRP levels are related to increased grey matter volume in anterior cingulate cortex and fatigue symptom in COVID-19 survivors in acute phase
R. Zhu, X. Niu, W. Bao, H. Li, X. Quan, G. Ye, Q. Zhu, M. Zhang
the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Impact: This study provides direct evidence of an association between immune biomarkers, ACC, and fatigue symptoms. These results point towards a putative etiological model of post-COVID-19 fatigue, in which elevated peripheral proteins are associated with structural changes in the ACC.
  5085. Identifying Depressive Disorder: Perspectives from an Individualized Radiomics-Based Structural Similarity Network
J. Wen, Y. Hao, L. Gong, L. Gao, H. Guo, G. Wen
Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China
Impact: Individualized radiomics-based structural similarity network shows great potential for serving as more reliable features in MDD diagnosis.
  5086. The Gray Matter Atrophy Pattern Associated with Abnormal Gait and Cognitive Impairment in HIV-Infected Individuals.
J. Sun, Z. Zhuo, Y. Zhang, J. Weng, K. Zhang
Xuanwu Hospital Capital Medical University, Beijing, China
Impact: This study provides insights into how infectious and systemic diseases, such as HIV, affect the brain by integrating multimodal data including imaging, behavioral assessments, and gene transcription analysis. This comprehensive approach enables a deeper understanding of disease pathology and mechanisms.
  5087. Emotion-associated white matter changes in thyroid eye disease: Comparative study using diffusion kurtosis and tensor imaging
M. Jiang, H. Zhanghai, Y. Song, X. Song, X. Tao
Shanghai Ninth People’s Hospital, Shanghai, China
Impact: This study demonstrates that DKI is more sensitive than DTI in detecting subtle white matter changes in thyroid eye disease. Our findings highlight potential neural mechanisms underlying emotional disturbances in this condition.
  5088. Alterations in hypothalamus subunits morphology and functional connectivity in patients with adult-onset hypothyroidism
L. Wang, J. Cao, J. Tian, L. Zhao
The First Clinical Medical College of Gansu University of Chinese Medicine ( Gansu Provincial Hospital), Lanzhou, China
Impact: This work may find alterations in the hypothalamus subunits at different phases of hypothyroidism, which may help us better understood the mechanisms underlying the brain damage caused by hypothyroidism.
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