ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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4875. Multi-Task
Learning with Hierarchical Label Consolidation for Efficient and
Accurate Brain MRI Segmentation of 169 Regions
P-C Chen, T-Y Huang, Y-R Lin, T-C Chuang, H-W Chung
National Taiwan University of Science and Technology, Taipei, Taiwan
Impact: The method enhances efficiency and accuracy in
brain MRI segmentation, allowing integration of additional
tasks like cortical thickness estimation, leading to a
multifunctional open-source brain MRI processing toolbox.
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4876. Sex-based
differences in cerebral cortical structural development: a
comparison between preterm and full-term neonates
Y. Zhang, Y. Feng, S. Wang, M. Wang, X. Li, J. Yang
The First Affiliated Hospital of Xi'an Jiaotong University,, Xi'an, China
Impact: A better understanding of sex-related
differences in healthy cerebral cortex structure during the
neonatal period may help identify risk factors and
protective mechanisms for brain disorders.
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4877. WITHDRAWN | ||
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4878. Association
of gray-white matter junction tissue volume loss with metabolic
biomarkers in patients with type 2 diabetes
G-H Jahng, C-W Ryu, Y. Tian, S. Park, I-K Jeong
Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of
Impact: This study contributes to the field of diabetes
and neuroimaging by introducing the concept of gwJTV as a
new MRI measure for evaluating brain tissue integrity in T2D
patients.
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4879. Potential
association between cognitive impairment and pre-pregnancy Body
mass index in women with preeclampsia
Y. Wang, X. Zhang, N. Wang, L. Yang, T. chen, L. Guo
Binzhou medical university, Yantai, China
Impact: Our findings suggest that the reduction of GMV
volume in bilateral frontal and temporal lobes in PE
patients can be used as a potential neuroimaging indicator
of brain injury.
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4880. Brain
iron alterations associated with metabolic syndrome in the UK
Biobank study cohort
X. Zhang, N. Wang, Y. Gao, C. Sui, Z. Cheng, P. Liang, Y.
Chen, J. Xin, L. Guo, C. Liang
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Impact: Iron deposition in the brains of metabolic
syndrome patients increases their susceptibility to brain
damage and possibly degenerative diseases. Understanding
this metabolic disturbance is crucial for managing brain
iron levels in Mets patients as they age.
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4881. Comparison
of the cortical thickness and gray matter volume alterations in
Multiple system atrophy and Parkinson’s disease
J. Peng, P. Wang, Y. Bao, G. Fan, E. Wang, Y. Ya, Y. Jia, P.
Wu
The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China, Suzhou, China
Impact: Our results enrich the knowledge of morphometric
MRI difference in MSA and PD, might become potentially
useful imaging biomarkers for differential diagnosis of MSA
and PD, and demonstrate the potential use of routine MRI in
performing their differential diagnosis.
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4882. Brain
Structural and Functional Connectivity Alterations in Heart
Failure Patients
C. Pan, Y. Pan, W. Tang, Q. Xie, T. Jia, Y. Qiu, L. Lu, J.
Chen
Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China
Impact: This study provides insights into the
neurological consequences of heart failure, potentially
guiding the development of interventions for associated
cognitive decline.
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4883. Correlation
of Gray Matter Volume with Transcriptional and Cellular
Characteristics in Post COVID-19 Olfactory Dysfunction Patients
J. Luan, G. Ma
China Japan Friendship Hospital, Beijing, China
Impact: This research identifies critical GMV changes in
post-COVID olfactory dysfunction patients, linking them to
specific genetic and cellular pathways. These findings can
inform future therapeutic strategies aimed at restoring
olfactory function and understanding post-COVID neurological
sequelae.
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4884. Quantification
of gray matter abnormalities in systemic lupus erythematosus
patients by synthetic MRI
K. Deng, M. Jiang, C. Wu, W. Cui, L. Long
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Impact: The microstructural abnormalities of the limbic
system may be a significant factor contributing to anxiety
in patients with systemic lupus erythematosus.
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4885. Microstructural
differences in white matter tracts in Alzheimer’s disease,
cerebrovascular disease, and Parkinson's disease
D. Broberg, R. Swartz, A. Lang, O. Investigators, A.
Roberts, R. Bartha
Western University, London, Canada
Impact: White
matter tract microstructure is slightly more preserved in
Parkinson’s compared to Alzheimer’s or cerebrovascular
disease. These results reinforce the need for
higher-quality, advanced diffusion imaging techniques to
detect the more subtle white matter degeneration in
Parkinson’s disease patients.
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4886. Prediction
of Lesion Growth in Multiple Sclerosis: A longitudinal Study
with High-resolution Whole-brain MRSI
B. Bo, T. Sheng, W. Tang, Z. Meng, Y. Zhao, Y. Li, W. Jin,
Z-P Liang, X. Chen, Y. Li
Shanghai Jiao Tong University, Shanghai, China
Impact: High-resolution whole-brain MRSI provides a
promising tool for predicting lesion growth and stratifying
patients with higher risk of enlarging lesions during
short-term follow-up in MS.
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4887. Precise
Quantitative Assessment of Hippocampal Subregional Structural
Changes Associated with Cerebral Small Vessel Disease
B. Chen, Y. Fu, L. Guo, C. Liang, C. Sui, Y. Gao, N. Wang,
X. Zhang, Y. Wang, Z. Cheng, P. Liang, Y. Chen, X. Huo, F.
Zhang
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, Jinan, China, China
Impact: This study provides data on HP subregion volume
changes related to CSVD load, providing new evidence for the
mechanism of cognitive-motor function impairment in CSVD,
and offering the potential for more precise imaging markers.
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4888. High
resolution sub-voxel magnetic susceptibility source separation
of pigeon head at 14.1T
H. Yang, L. Wang, Z. Li, J. Li, M. Wang, C. Tian, Q. Ye
High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
Impact: The
distribution of paramagnetic and diamagnetic susceptibility
disentangled by χ-separation could provide new insights into
the understanding of the mechanisms by which pigeons sense
and use the Earth’s magnetic field for orientation and
navigation.
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4889. Brain
age is stable across the menstrual cycle: results from a
high-density sampling study
L. Wood, M. Wright, I. Driver, K. Murphy, H. Chandler
Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom
Impact: Menstrual cycle phases may not provide a
sufficient representation of endocrine influences on
neuroanatomy. Therefore, future research should investigate
the potential effect of measured ovarian hormone levels on
brain morphology, utilizing an age prediction framework.
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4890. Altered
brain iron deposition patterns in iron deficiency anemia
H. Salcudean, C. González-Zacarías, S. Mejia, E. Carpenter,
B. Xu, S. Suriany, S. Verma, A. Joshi, P. Chiarelli, R.
Leahy, J. Wood
Children's Hospital Los Angeles, Los Angeles, United States
Impact: This is the first study to demonstrate abnormal
brain iron deposition in IDA patients, proportional to IDA
severity. Brain iron deposition may provide
pathophysiological insight into cognitive dysfunction and
serve as an imaging biomarker to guide iron replacement
strategies.
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4891. Economical
and Diagnostic Quality Aspects Relevant for a Radiology
Department Considering Implementation of Deep Learning –
Augmented MRI
R. Bammer, J. Warner, J. Richer, C. Blackmore, D. Staeb, J.
Jin, R. Blagin, D. Anderson, D. Saddik, A. Stemmer, D.
Nickel, K. O'Brien, S. Amukotuwa
Monash University, Clayton, Australia
Impact: We identified the most time-consuming scan
protocols by weighting the frequency of utilization by
protocol duration. Leveraging 2D+3D DL reconstruction, these
protocols were dramatically shortened, freeing up
approximately 34% of MRI time, allowing increased throughput
while improving diagnostic quality.
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4892. DISTRIBUTION
OF PARAMAGNETIC IONS IN EX-VIVO HUMAN BRAIN SAMPLES USING
ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY
J. Azevedo, F. Otsuka, R. Rodriguez, A. Avanzine, V. Souza,
F. Jr, M. Otaduy, C. Salmon
Graduate Program in Neurology, FMRP, University of São Paulo, Ribeirão Preto, Brazil
Impact: This research suggests that copper-iron balance
in the brain could serve as an indicator of healthy metal
regulation, with implications for neurodegenerative disease
research and in vivo brain metal monitoring.
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4893. Ultra-low
Field Portable MRI as a Neuroimaging Tool to Identify and
Characterize Brain Atrophy in Patients with Neurodegenerative
Diseases
A. Pathakamuri, H. Kazimuddin, J. Kwan, L. Turtzo, L. Latour,
S. Horovitz
National Institute of Neurological Disorders and Stroke, Bethesda, United States
Impact: Ultra-low field (ULF), portable MRI can identify
brain atrophy with a similar sensitivity and specificity as
standard 3T MRI. ULF may serve as a more accessible clinical
research and diagnostic tool to identify and understand
neurodegenerative disease mechanisms.
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