ISMRM25 - You, Too, Can Conduct Multi-Center Research!

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

You, Too, Can Conduct Multi-Center Research!

Weekday Course

ORGANIZERS: Christian Federau, Jae Song, Dan Wu

Thursday, 15 May 2025

316B

08:15 - 10:15

Moderators: Julien Savatovsky & Moss Zhao

Skill Level: Basic to Advanced

Session Number: Th-01

No CME/CE Credit

Session Number: Th-01

Overview
This session will cover the conduct of multi-center research. Study design, data management, image standardization and/or harmonization, and statistical analysis will be discussed. Regulatory and ethical issues will be reviewed. The session will conclude with a panel discussion with all speakers and give the audience an opportunity to ask questions.

Target Audience
All, non-radiologists and radiologists, all levels of experience.

Educational Objectives
As a result of attending this course, participants should be able to:
• Describe how to plan a multi-center research study;
• Apply methods of image standardization and/or harmonization; and
• Describe regulatory challenges of multi-center research.

08:15		Overview of Multi-Site Clinical Trials View Presentation Video James Goodman Impact: This overview of multi-site clinical trials, a sub-set of clinical research, is intended to provide a high-level introduction to various considerations and components that are necessary for a successfully executed clinical trial.
08:30		Designing Multi-Center Research: Lessons Learned View Presentation Video Linda Chang Impact: Many “Lessons Learned” from Multi-Center Studies, including the “pros” and “cons” for multi-center studies, examples of these studies, and how best to provide data sharing, monitoring and clinical oversights for such studies, will be discussed.
08:45		Bringing Home a New Sequence & Running It View Presentation Video David Mummy Impact: Using a multi-site study of hyperpolarized Xenon pulmonary MRI as an example, we'll talk about implementing a new pulse sequence on different scanner platforms, non-standard data transfer for reconstruction and analysis, site qualification and QC, and (a lot of) lessons learned along the way.
09:00		The Role of Phantoms in Multi-Center Imaging Trials View Presentation Video Kalina Jordanova Impact: Measurement variations in multi-center studies confound results, especially for quantitative methods. Phantoms can disentangle variations due to biological sources from system changes. We discuss considerations for phantom use in multi-center studies.
09:15		Statistical Aspects of Multi-Center Research View Presentation Video Russell Shinohara Impact: This presentation will be a brief overview of scanner effects and statistical considerations in multi-center imaging studies. It will focus on harmonization, study design, and power considerations.
09:30		Data Standardization, Pre-Processing & Harmonization View Presentation Video Fengling Hu Impact: Learn techniques to combine neuroimaging data across sites, boosting statistical power and reproducibility. This session highlights standardization, pre-processing, and harmonization methods, focusing on crucial concepts, established tools, and current challenges in harmonization.
09:45		Lessons from the 7,000-Patient 27-Center Breast MRI MIPA Study Francesco Sardanelli
10:00		Panel Discussion Julien Savatovsky