ISMRM25 - MR-Guided Interventions

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

MR-Guided Interventions

Weekday Course

ORGANIZERS: Shoko Hara, Harpreet Hyare, Nadya Pyatigorskaya, Allen Song, Wietske van der Zwaag

Wednesday, 14 May 2025

311

13:30 - 15:30

Moderators: Salil Soman & Holden Wu

Skill Level: Intermediate to Advanced

Session Number: W-03

No CME/CE Credit

Session Number: W-03

Overview
This course will explore advanced MRI-guided interventions, focusing on techniques such as LIFU, HIFU, TMS, and TDCS. Participants will gain insights into their principles, clinical applications, and the latest research developments, enhancing their ability to utilize these technologies in scientific and clinical settings.

Target Audience
Scientists and clinicians interested in MRI-guided interventions and new potentials of MRI.

Educational Objectives
As a result of attending this course, participants should be able to:
• Discuss the principles and applications of MRI-guided LIFU and HIFU;
• Evaluate the efficacy and potential of MRI-guided neuromodulation techniques; and
• Assess the clinical outcomes and advancements in blood-brain barrier (BB) opening techniques.

13:30		Advancements in LIFU: Therapeutic Potential & Clinical Applications Wuwei Feng
14:00		Innovations in Blood-Brain Barrier Opening with Focused Ultrasound (FUS) View Presentation Video Elizabeth Hutchinson Impact: Learning Objectives The Blood Brain Barrier (BBB) Anatomy and Physiology Why open the BBB? Focused Ultrasound with Microbubbles The FUS+μB paradigm Microbubble physical and chemical properties State of the field Seminal studies Representative studies
14:30		Advances in Neuromodulation Techniques View Presentation Video Jean-Francois Aubry Impact: The latest technological advances paved the way to clinical evidence of ultrasonic neuromodulation with three different modalities: (i) targeted drug delivery, (ii) non-invasive deep brain stimulation and (iii) millimetric neurosurgery.
15:00		HIFU in Brain Therapy: General Concept & Applications to ET & PD Treatment View Presentation Video Meiyun Wang Impact: MRgFUS is an effective treatment method for PD and ET. The improvement in tremor symptoms after MRgFUS treatment is associated with changes in specific brain functional networks. MRgFUS-mediated BBB opening and neuromodulation have great potential for the treatment of brain disorders.