ISMRM25 - Advanced Contrast Mechanisms: From Multi-Parametric to Metabolic Imaging

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Advanced Contrast Mechanisms: From Multi-Parametric to Metabolic Imaging

Weekend Course

ORGANIZERS: Jessica Bastiaansen, Weitian Chen, Simon Robinson, Yuriko Suzuki

Sunday, 11 May 2025

312

07:45 - 11:35

Moderators:
Part II: Francesca Branzoli & Guodong Weng
Part I: Hua Guo & Radhouene Neji

Skill Level: Advanced

Session Number: WE-20

CME Credit

Session Number: WE-20

Overview
Building on prior educational sessions on the basics of MR contrasts (“The Very Basics”) and physics and modelling of the underlying mechanisms (“Modelling from the ground up”), we take a deep dive into those methods, focussing on advanced sequences, reconstruction and analysis.

Target Audience
Researchers with a basic understanding of contrast mechanisms who are interested in learning about more recent and sophisticated approaches to a range of methods including multi-parametric mapping (MPM), diffusion, perfusion, chemical exchange saturation transfer (CEST), spectroscopy (MRS(I)), X-nuclei imaging and hyperpolarisation.

Educational Objectives
As a result of attending this course, participants should be able to:
• Describe the most recent developments in acquisition, including fast methods and sequences which provide more information about the contrasts under examination;
• Discuss the wealth of information which can be gleaned from the data using state-of-the art analysis approaches;
• List the artifacts and current shortcomings in each field; and
• Present an overview of the direction of each field and unmet needs.

Part I
07:45		Multi-Parametric Mapping View Presentation Video Nikolaus Weiskopf Impact: This lecture will explore multi-parametric mapping (MPM) for brain microstructure characterization (myelin, iron) with the focus on R1, R2*, proton density (PD) and magnetization transfer (MT) saturation mapping using 3D spoiled multi-echo gradient echo acquisitions.
08:10		Advanced Diffusion Acquisition View Presentation Video Dan Wu Impact: This ISMRM talk covers advanced diffusion MRI techniques, including recent development in acquisition (Multi-Band, SMSlab, EPTI, etc.), advanced encoding (Double Diffusion, Tensor-Valued), AI-driven acceleration, and emerging trends like hybrid imaging and high-gradient systems.
08:35		Advanced Diffusion Analysis Alexander Leemans
09:00		Advanced Perfusion Methods View Presentation Video Xingfeng Shao Impact: This talk covers advanced brain perfusion imaging with a focus on water exchange across brain barriers, using contrast- and non-contrast enhanced methods. Clinical applications including early BBB dysfunction in neurodegenerative disorders will also be discussed.
09:25		Break & Meet the Teachers
Part II
09:50		Chemical Exchange Saturation Transfer Yi Zhang
10:15		Magnetic Resonance Spectroscopy & Spectroscopic Imaging Lijing Xin
10:40		X-Nuclei Imaging View Presentation Video Yasmin Blunck Impact: This talk addresses the key challenges of x-nuclei MRI. It focuses on acquisition strategies for enhanced image quality and contrast as well as signal analysis techniques such as quantification and relaxometry.
11:05		Hyperpolarization View Presentation Video Franz Schilling Impact: Over the last two decades, hyperpolarized MRI has gained significance in both preclinical and clinical studies. Within this talk, we will learn about basic aspects, challenges, imaging biomarkers and clinical translation of this rapidly developing technology.