MR of Cancer

Room 204 A/B
12:30 – 15:30

Business Meeting

-Installation of Group Chairman and Secretary for 1999.
-Results of the 1999 Election of Officers for the year 2000.
-Financial Status of the Study Group and the Negendank Fund.
-Summary Report on the St. Louis Workshop (Nov. 1998).
-ISMRM Program Committee Report and Planning Activities.
-Status of the ISMRM Website and the Cancer MR Email Listserver.
-Proposal for a Metabolite MRS Webserver (Structure and NMR Databank).
-Future Meetings and Workshops.

Scientific Meeting

The following THEME will be introduced by a guest lecturer; this theme carries with it a CHALLENGE to the MR community; selected members of a discussion panel will give short summaries relating to the list of topics below and an open discussion session with active audience participation will take place.

Theme: Tumor vascularization, microcirculation, and tissue perfusion: their influence on tumor oxygenation, pH, and drug pharmacokinetics; their importance in determining cancer treatment strategies and therapy response.

Challenge: How can noninvasive MRI/MRS methods be used for monitoring these physiologic parameters, for developing improved therapies, or for clinical patient management?

Principles of Oxygen Transport in Tumors, Guest Lecturer – Mark W. Dewhirst, Duke University Medical Center, Durham, NC, USA.

Suggested Topics for Discussion Session

Tumor detection and characterization on the basis of vascular properties using MRI

  • dynamic MRI, MRA, and perfusion-weighted imaging
  • constrast agents and T1-weighting vs. T2(*)-weighting
  • advantages of multiphase dynamic MRI with contrast agents
  • use of contrast agents with different molecular weights; superparamagnetic particles
  • quantitation of tumor vascular volume, flow, and permeability
  • applicability and limitations of pharmacokinetic modeling
  • indicators of angiogenesis (vascular volume and permeability, expression of angiogenic growth factors) and MR methods of assessment
  • MR monitoring of tumor oxygenation

    Tumor therapy and MR signatures of therapy response