Fifth Annual General Meeting of the British Chapter of I.S.M.R.M.

Thursday 18th November

09:30 - 10:30 Registration and Coffee

10:30 - 10:40 Introductory Remarks Professor Graeme Bydder

10:40 - 11:15 Invited Plenary speaker: Professor Stephen Humphries

Molecular Biology reaches the human

11:15 - 12:30 Session 1: Novel Applications Chair: Professor Jo Hajnal

    11:15 Invited speaker: Dr Angelo Bifone    Probing blood oxygenation with hyperpolarised 129Xe NMR.

    11:35 Invited speaker: Dr Paul Marsden Simultaneous PET and NMR.

Contributed papers:

    11:55 Adams EW, et al. Magnetic resonance imaging of the neonatal lung, Hammersmith Hospital.

    12:07 D'Arcy JA, et al. MR thermography using radial sampling. Marsden

    12:19 Medina RA, et al. A comparison of glucose tracers in the isolated perfused rat heart using the PANDA system (PET and NMR dual acquisition). Guy's, Kings and St Thomas'.

12:45 - 2:30 Lunch and Posters

2:30 - 4:00 Session 2a: Functional MRI/S Chair: Professor Bob Turner

2:30 Invited speaker: Professor John Mayhew Signal source separation in the spectroscopic analysis of neural activity in brain.

2:50 Invited speaker: Professor Steve Williams (IOP - fMRI)

Contributed papers:

3:10 Gibson AM, et al. High speed fMRI using multi-slice PRESTO-EPI. Nottingham

3:22 McRobbie DW, et al. The effect of fat saturation on functional MRI using long TR echo planar sequences. Charing Cross Hospital.

3:34 Deichmann R, et al. Optimization of 3D MPRAGE sequences for structural brain imaging. Institute of Neurology.

2:30 - 4:00 Session 2b: Hardware and Sequence Developments Chair: Prof Young

2:30 Invited speaker: Dr Hugh Seton SQUID Preamplifiers for Low Field MRI

2:50 Invited speaker: Dr Rory Warner Ultra high field superconducting magnets for MRI

Contributed papers:

3:10 Alecci M, et al. Use of endcap for improving the axial RF field homogeneity of 3 tesla birdcage coils. University of Oxford.

3:22 Prock T, et al. Two 3D finite element models for the safe prediction of maximum SAR values for surface coil MRS studies. Marsden.

3:34 Hand JW , et al. SAR and tissue temperature: effects due to a RF decoupling coil between 64 and 213 MHz. Hammersmith Hospital.

4:00 - 4:15 Tea

4:15 - 5:45 Session 3: Tissue Analysis Chair: Professor Peter Styles

4:15 Invited speaker: Professor Jeremy Nicholson High resolution 1H NMR spectroscopy of biofluids and intact tissues: A Metabonomic approach to disease diagnosis)

4.35 Invited speaker: Professor Alan Jackson A new method for measuring endothelial permeability in tumours using first pass data.

Contributed papers:

4:55 Parkes H, et al. High resolution 1H NMR studies of cerebrospinal fluid. Institute of Child Health

5:07 Cea G, et al. Impaired skeletal muscle oxidative ATP production in inflammatory myopathy assessed by 31P MRS. University of Oxford.

5:19 So P-W, et al. 1H NMR studies on the metabolic effects of hypoxic flush storage, oxygenated persufflation or continuous oxygenated perfusion in the rat liver at hypothermia. Hammersmith Hospital.

5:31 Howe FA, et al. Classification of human brain tumors with quantitative short echo 1H MRS. St George's.

5:45 - 6:00 British Chapter Annual Meeting

6:15 - 7:45 Poster Session

8:00 Conference Dinner

Friday 19th November

08:30 - 9:00 Registration and Coffee  

9:00 Introductory Remarks by Dr Paul Goddard for the MRRA  

9:15 - 10:45 Session 4: MRI at the Clinical Frontier Chair: Dr Simon Blease

9:15 Invited speaker: Professor David Menon MR studies in the critically ill patient with acute brain injury: potential, pitfalls and preliminary success.

9:35 Invited speaker: Dr Penny Gowland Quantitative MRI in pregnancy.

Contributed papers:

9:55 Hawnaur JM, et al. Magnetic resonance imaging of the normal and abnormal sub-areolar breast. University of Manchester.

10:07 Tyler D, et al. Single shot transverse relaxation time measurement in the human placenta in vivo using multi-echo echo planar imaging at 0.5T. University of Nottingham.

10:19 Utting JF, et al. Practicalities of continuous arterial spin labelling for clinical applications. Institute for Child Health.

10:45 - 11:00 Tea

11:00 - 12:30 Workshop A Workshop B

Image analysis & registration Dynamic MRI

Dr Nadeem Saeed (ICSM) Dr Glyn Coutts (ICSM)

Dr Louis Lemieux, (ION) Dr DN Firmin (NHLI)


11:00 - 12:30 MRRA (UK) Business Meeting

12:30 - 2:00 Lunch and Posters

2:00 - 3:30 Session 5a: MR Guided Procedures Chair: Dr Nandita De Souza

2:00 Invited speaker: Dr Martin Paley Applications of interventional MRI on a dedicated system.

2:20 Invited speaker: Dr Margaret Hall-Craggs

Contributed papers:

2:40 Keen M, et al. Sequences for the detection of temperature related changes during interstitial laser ablation of tissues. Bristol.

2:49 Law P, et al. IMR guided laser ablation of uterine fibroids, St Mary's Hospital.

2:58 Gedroyc MWM. IMR guided laser ablation of kidney tumours. St Mary's Hospital.

3:07 Gilderdale DJ, et al. MR endoscopy: Novel hardware developments and in vitro studies. Hammersmith Hospital.

3:16 Callaway M, et al. Interventional MRI using a low field system. Initial results of cutting needle biopsies in the thorax and abdomen. Bristol.

2:00 - 3:30 Session 5b: CNS Spectroscopy Chair: Professor Martin Leach

2:00 Invited speaker: Dr Kishore Bhakoo A cellular perspective on CNS Spectroscopy.

2:20 Invited speaker: Professor David Gadian Magnetic resonance spectroscopy in children with brain disease.

Contributed papers:

2:40 Garnett MR, et al. Early 1H-MRS in normal appearing white matter correlates with outcome in traumatically head injured patients. University of Oxford.

2:52 Kustermann E, et al. Cerebral glucose metabolism in a transgenic animal model of ALS as detected by in vivo 13C MRS. University of Nottingham.

3:04 Wylezinska M, et al. The rate of the forward creatine kinase reaction correlates with adenosine triphosphate depletion during delayed cerebral energy failure. University College London.

3:16 McLean MA, et al. Metabolite Content in cerebral grey and white matter studied with short-echo time 1H-MRSI. Chalfont.

3:30 - 4:00 Tea

4:00 - 5:30 Session 6a: Diffusion, Perfusion and MT Chair: Dr Mark Horsfield

4:00 Invited speaker: Dr Alan Connelly: The use of quantitative diffusion imaging in children.

4:20 Invited speaker: Professor Steve Williams The relationship between diffusion changes and cell membrane function.

Contributed papers:

4:40 Blamire AM, et al. Spin echo entrapped perfusion image (SEEPAGE): A new MR perfusion technique. University of Oxford.

4:52 Bainbridge A, et al. Demonstration of the effect of coil loading on the MT parameters of different sized agar gel samples. University of Exeter.

5:04 Nguyen Q, et al. Quantitative diffusion weighted imaging using diffusion prepared TurboSTEAM. University College London.

5:16 Lythgoe MF, et al. Delayed cell death following reperfusion of the brain is a gradual phenomenon: Implications for cardiac resuscitation and stroke. Institute of Child Health.

4:00 - 5:30 Session 6b: Recent Clinical Advances (MRRA)Chair: Dr René Tayar

4:00 Invited speaker: Dr Tim Lewis: Recent Advances in Neurology MR

4:30 Invited speaker: Dr Christine Heron: Recent Advances in Orthopaedic MR

5:00 Invited speaker: Dr Paul Goddard: Recent Advances in Thoracic MR

5:30 Concluding Remarks (Professor Ian Young)


Wolber J, Santoro D, Cherubini A, Leach MO, Bifone A. Transverse relaxation times of hyperpolarised 129Xe. CRC Clinical Magnetic Resonance Research Group, The Institute of Cancer Research, The Royal Marsden NHS Trust, Sutton, Surrey.

Ajayi-Obe M, Saeed N, Battin M, Duggan P, Maalouf E, Al Nakib L, Counsell S, Fletcher A, Rutherford M, Edwards D. Quantification of cortical folding by magnetic resonance imaging using image segmentation and cortical contour following. Department of Paediatrics and Robert Steiner MR Unit, Hammersmith Hospital, London.

Manton DJ, Knowles AJ, Turnbull LW. Application of neural networks to fMRI analysis: Reduction in false positive rates through modified training regimes. University of Hull MRI Centre, Hull Royal Infirmary, Hull.

Larkman DJ, Herlihy AH, Hajnal JV. Elimination of gradient roll over artefacts in MR images. Robert Steiner MRI Unit, ICSM, Du Cane Road, London.

Marciani L, Manoj P, Smith A, Moore R, Young P, Tyler D, Fillery-Travis A, Spiller R, Gowland P. Echo-planar imaging evaluation of the forces produced by the human stomach in fracturing model solid food. MR Centre University of Nottingham and Department of Gastroenterology, QMC Hospital, Nottingham. Institute of Food Research, Norwich.

Crilley JG, Boehm EA, Rajagopalan B, Blamire AM, Styles P, Hilton-Jones D, Clarke K. MR spectroscopy evidence of abnormal cardiac energetics in Becker muscular dystrophy. MRC MRS Unit, John Radcliffe Hospital and Department of Biochemistry, University of Oxford, Oxford.

Griffin JL, Nicholls AW, Mortshire-Smith R, Rae C, JK Nicholson. High resolution magic angle spinning of cerebral tissue as applied to a mouse model of Duchenne's muscular dystrophy. Biological Chemistry, Imperial College, London and Merck, Sharp & Dohme, Harlow. Biochemistry Department, University of Sydney, Sydney.


Chung Y-L, Rider L, Bell JD, Zemel L, Rennebohm R, Passo M, White P, George S, Katona I, Miller F, Scott D. Muscle metabolites, detected in urine, reflect disease activity in juvenile dermatomyositis (JDM). The Robert Steiner MR Unit, Hammersmith Hospital and King's College London.


Vejchapipat P, Williams SR, Spitz L, Pierro A. Intestinal ischaemia-reperfusion injury: Effects on intestinal and hepatic energy metabolism. RCS Unit of Biophysics and Surgery Unit, Institute of Child Health, London and Imaging Science and Biomedical Engineering, University of Manchester.

Manners D, Cea G, Styles P, Taylor DJ. Quantitative MRI of T2, water and fat facilitates the study of muscle disease progression. MRC Clinical & Biochemical MRS Unit, Department of Biochemistry, University of Oxford, Oxford.

Counsell SJ, Maalouf EF, Al-Nakhib L, Allsop JM, Ajayi-Obe MOA, Herlihy AH, Edwards AD, Rutherford MA. Magnetic resonance imaging assessment of myelination in the preterm brain. Robert Steiner MR Unit and Department of Paediatrics, Hammersmith Hospital, London.

Garnett MR, Blamire AM, RG Corkill, JD Young, B Rajagopalan, Styles P, Cadoux-Hudson TAD. Altered cellular metabolism in severe head injury: A 31P-MRS study. MRC Biochemical and Clinical MRS Unit, Department of Biochemistry, University of Oxford. Department of Neurosurgery, Radcliffe Infirmary and Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford.

Thornton JS, Ordidge RJ, Brooks K, Cady EB, Clemence M, Nguyen Q, Noone M, O'Brien FE, Parker N, Sakata Y, Sellwood MW, Wylezinska M, Wyatt JS. Cerebral tissue water T2 following transient hypoxia-ischaemia in neonatal piglet brain. Departments of Medical Physics and Bioengineering, and Paediatrics, University College London.

Corkill RG, Garnett MR, Blamire AM, Rajagopalan B, Cadoux-Hudson TAD, Styles P. Pre-operative diffusion-weighted imaging and proton spectroscopy of the periventricular tissues can distinguish between good and poor outcome from surgery in normal pressure hydrocephalus. MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford and Department of Neurosurgery, Radcliffe Infirmary, Oxford.

Thomas DL, Lythgoe MF, Pell GS, Gadian DG, Ordidge RJ. Quantitative aspects of FAIR perfusion imaging using FOCI labelling pulses. RCS Unit of Biophysics, Institute of Child Health and Department of Medical Physics, University College London, London.

Al Nakib L, Pennock J, Hajnal JV, Dubowitz LMS, Bydder GM, Cowan F. Diffusion weighted (DW) MR imaging in neonatal stroke - Timing of onset lesions and prediction of lesion size. Department of Paediatrics and Robert Steiner MR Unit, Hammersmith Hospital, London.

Herbert AL, Davies NP, Vennart W, Clemence M, Summers IR, Waterton JC. Binomial pulse presaturation: Demonstration and optimization of MT response as a function of agarose gel concentration. School of Physics, University of Exeter, Exeter.