ISMRM Workshop Series • 21-24 July 2019

ISMRM Workshop on
MRI of Obesity & Metabolic Disorders
Matrix Building, Biopolis, Singapore

Program


Registration & Setup – Sunday, 21 July 2019
16:00 Registration & Speaker Upload Available until 18:00
17:00 Opening Reception
18:00-18:20 Informal Talk (Introduction by S. Velan) Patrick Cozzone, Ph.D., M.B.A.
Singapore Bioimaging Consortium
Singapore
19:00 Adjourn
 
Day 1 – Monday, 22 July 2019
07:00 Registration & Speaker Upload Available
Breakfast on Own
08:10 Announcements, Logistics & Housekeeping Houchun Harry Hu, Ph.D.
Nationwide Children’s Hospital (Co-Chair)
Columbus, OH, USA

Sambasivam Sendhil Velan, Ph.D.
Singapore Bioimaging Consortium (Co-Chair)
Singapore
08:25 Guest of Honor Welcome Address Frederick Chew, M.E., M.S.M.
A*STAR
Singapore
08:35 Opening Remarks
 
Patrick Cozzone, Ph.D., M.B.A.
Singapore Bioimaging Consortium
Singapore
 
Session 1: Diabetes & Insulin Resistance
Houchun Harry Hu, Ph.D. & Johan Gunnar Eriksson, M.D., Ph.D.
08:45 Type 2 Diabetes in Asia: Is It Really Different? Tai E. Shyong, Ph.D., FRCP, MBChB
National University of Singapore
Singapore
09:15 Ectopic Fat & Cardiometabolic Disease Risk in Caucasian, African-American & Latino Youth: Effects of Sex, Race & Ethnicity Gabriel Shaibi, Ph.D.
Arizona State University
Tempe, AZ, USA
09:45 Break & Speaker Upload Available
 
Session 2: Recent Advances in Water-Fat MRI
Moderators: Diego Hernando, Ph.D. & Charles McKenzie, Ph.D.
10:30 State-of-the-Art Methods & Emerging Techniques for Quantitative MRI of Fat Holden Wu, Ph.D.
University of California, Los Angeles
Los Angeles, CA, USA
11:00 MRI Quantification of the Fatty Acid Composition: Methods & Applications Pernilla Peterson, Ph.D.
Lund University
Malmö, Sweden
11:30 Quantitative Biomarker Imaging & Analysis in NASH Clinical Trials (PDFF & MR Elastography) Michael S. Middleton, M.D., Ph.D.
University of California, San Diego
La Jolla, CA, USA
12:00 Lunch & Speaker Upload Available
 
Session 3: Brown/Beige/Brite Adipose Tissue
Moderators: Rosa Tamara Branca, Ph.D. & Sambasivam Sendhil Velan, Ph.D.
13:30 Brown & Browning Adipose Tissues: Metabolic Significance Barbara Cannon, Ph.D.
Stockholm University
Stockholm, Sweden
14:00 Stem Cell Factors for Adipocyte Maturation & Browning Shigeki Sugii, Ph.D.
Singapore Bioimaging Consortium
Singapore
14:30 BAT Detection by Non-MRI Methods Melvin Khee Shing Leow, MBBS, MMed, FAMS, FACE, FACP, FRCP
Singapore Institute for Clinical Sciences
Singapore
15:00 MR Detection of BAT: Opportunities & Limitations Rosa Tamara Branca, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC, USA
15:30 Break & Speaker Upload Available
 
Session 4: Power Pitch & Poster Sessions
Moderators: Dimitrios Karampinos, Ph.D. & Jürgen Machann, Ph.D.
16:00 Power Pitch Session
Evaluation of Interscapular Brown Adipose Tissue & Skeletal Muscle IMCL in High-Fat-Diet-Fed Rodents with High-Intensity Exercise Intervention Venkatesh Gopalan, Ph.D.
Singapore Bioimaging Consortium
Singapore
Functional Evaluation of Brown Adipose Tissue in Aging Rodent Model by 3D Imaging Rengaraj Anantharaj, Ph.D.
Singapore Bioimaging Consortium
Singapore
Investigation of Metabolic Markers of Brown Adipose Tissue by High Resolution Magic Angle Spinning Spectroscopy (HR-MAS) Jadegoud Yaligar, Ph.D.
Singapore Bioimaging Consortium
Singapore
Characterization of Brown Adipose Tissue Activity Using Quantitative Multiparametric MRI Chuanli Cheng, Ph.D.
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Shenzhen, China
Brown Adipose Tissue Is Associated with Lower Liver Fat in Healthy Asian Children Mya Thway Tint, Ph.D.
National University of Singapore
Singapore
Challenges of Identifying Human Fetal Brown Adipose Tissue Using MRI Stephanie A. Giza, B.Sc.
Western University
London, ON, Canada
Measuring Liver T1 in the Presence of Glycogen & Hydration Ferenc Mozes, M.Sc.
University of Oxford
Oxford, England, UK
Multiparametric MRI as a Composite Biomarker for NASH & NASH with Fibrosis Andrea Dennis, Ph.D.
Perspectum Diagnostics
Oxford, England, UK
Automated Analysis of Liver R2* Maps Using Artificial Intelligence Alexandre Triay Bagur, M.Sc.
Perspectum Diagnostics
Oxford, England, UK
Comparison Between Improved Histological Fat Quantification Using Machine Learning & MRI for Assessment of Non-Alcoholic Fatty Liver Disease Benjamin Irving, Ph.D.
Perspectum Diagnostics
Oxford, England, UK
Multiparametric Magnetic Resonance Imaging Accurately Classifies Liver Injury in Patients with Non-Alcoholic Fatty Liver Disease Filza Aslam, Ph.D.
Perspectum Diagnostics
Oxford, England, UK
Prevalence of Non-Alcoholic Fatty Liver Disease in a Mexican Paediatric Population Diagnosed Non-Invasively by Multiparametric Magnetic Resonance Imaging Helena Thomaides-Brears, Ph.D.
Perspectum Diagnostics
Oxford, England, UK
Use of MRI to Describe the Relationship Between Fatty Pancreas, Body Fat & the Risk of Metabolic Syndrome & Insulin Resistance in Obese Chinese Adolescents with Non-Alcoholic Fatty Liver Disease Chileka Chiyanika, M.Sc., PgD
The Chinese University of Hong Kong
Shatin, Hong Kong, China
Prevalence of Fatty Liver Disease & the Association with Cardiac Remodeling in Healthy Singaporeans Desiree-Faye Toh, M.Sc.
National Heart Centre Singapore
Singapore
16:45 Poster Session
18:00 Group Photo
18:30 Siemens Healthineers-Hosted Dinner & Presentation
 
Day 2 – Tuesday, 23 July 2019
07:00 Registration & Speaker Upload Available
Breakfast on Own
07:50 Housekeeping & Announcements Houchun Harry Hu, Ph.D.
  &
Sambasivam Sendhil Velan, Ph.D.
08:00 Imaging Zinc Secretion from the Pancreas & Prostate Using Responsive MRI Contrast Agents
(Introduction by P. Cozzone)
A. Dean Sherry, Ph.D.
UT Southwestern Medical Center
Dallas, TX, USA
 
Session 5: Muscle & Adipose Tissue
Moderators: Dimitrios Karampinos, Ph.D. & Holden Wu, Ph.D.
08:45 Quantitative Fat Imaging in Neuromuscular Disease: Methods & Applications Hermien Kan, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands
09:15 MRS of Intramuscular Lipids: How to & Why Chris Boesch, M.D., Ph.D.
University of Bern
Bern, Switzerland
09:45 MR-Based Phenotyping in Metabolic Research Studies: Impact of Whole-Body Adipose (& Lean) Tissue Distribution & Ectopic Lipids Jürgen Machann, Ph.D.
Universitätsklinikum Tübingen
Tübingen, Germany
10:15 Break & Speaker Upload Available
 
Session 6: Imaging Fat in Fetus, Neonates & Children
Moderators: Charles McKenzie, Ph.D. & Sambasivam Sendhil Velan, Ph.D.
10:50 MRI of Fat & Metabolism in Pregnancy & Beyond Charles McKenzie, Ph.D.
University of Western Ontario
London, ON, Canada
11:00 MRI of the Mechanisms of Fetal Development Penny Gowland, Ph.D.
University of Nottingham
Nottingham, England, UK
11:30 Developmental Determinants of Childhood Adiposity & Body Fat Partitioning Yung Seng Lee, MBBS, MMed, Ph.D., MRCP, FRCPCH, FAMS
National University of Singapore
Singapore
12:00 Lunch & Speaker Upload Available
 
Session 7: MR Elastography (Obesity, Liver & Beyond)
Moderators: Houchun Harry Hu, Ph.D. & Takeshi Yokoo, M.D., Ph.D.
13:30 Role of MR Elastography in Obesity Era Claude Sirlin, M.D.
University of California, San Diego
San Diego, CA, USA
14:00 MR Elastography: The Cutting Edge & Remaining Technical Challenges Meng Yin, Ph.D.
Mayo Clinic
Rochester, MN, USA
14:30 The Elastography Battle: MRI vs. Ultrasound Takeshi Yokoo, M.D., Ph.D.
University of Texas Southwestern Medical Center
Dallas, TX, USA
15:00 Break & Speaker Upload Available
 
Session 8: Proffered Papers - Oral Session
Moderators: Rosa Tamara Branca, Ph.D. & Jürgen Machann, Ph.D.
15:30 Accelerated Volumetric Free-Breathing Liver Fat Quantification Using Sparsity-Constrained 5D Tensor Reconstruction Shu-Fu Shih, M.Sc.
University of California, Los Angeles
Los Angeles, CA, USA
15:40 LiverMap®: Mapping Liver Fibrosis, Inflammation, Fat & Iron With Multi-Parametric Multi-Component Relaxometry (mpMCR) Paul Clark, Ph.D., B.E. (Hons)
MagnePath Pty, Ltd.
Perth, WA, Australia
15:50 Free-Breathing Three-Dimensional Stack-of-Radial Liver R2* Quantification in Pediatric Patients at 3 Tesla Xiaodong Zhong, Ph.D.
Siemens Healthcare
Los Angeles, CA, USA
16:00 Fat Deblurring in Golden Angle Radial Stack-of-Stars Multi-Echo Gradient Echo for Navigator-Gated High-Resolution Water-Fat Imaging Christoph Zöllner, M.Sc.
Technische Universität München
Munich, Germany
16:10 In Vivo Validation of MRI- & MRS-Based Quantification of Fatty Acid Composition Against Gas Chromatography Lena Trinh, M.Sc.
Lund University
Lund, Sweden
16:20 Brown Adipose Tissue Water ADC Quantification with Diffusion-Weighted MR Spectroscopy in the Human Supraclavicular Fat Mingming Wu, M.Sc.
Technische Universität München
Munich, Germany
16:30 Water-Fat MRI Used for the Assessment of In Vivo BAT Thermogenesis in Mice Clemens Diwoky, Ph.D.
University of Graz
Graz, Austria
16:40 Intraindividual Difference Between Supraclavicular PDFF & Subcutaneous PDFF Is Associated with Cold-Induced Thermogenesis in Adults Daniela Franz, Dr. Med.
Technische Universität München
Munich, Germany
16:50 Assessment of Local Human Brown Adipose Tissue Changes After Cold Exposure Aashley Sardjoe Mishre, M.Sc.
Leiden University Medical Center
Leiden, The Netherlands
 
Session 9: Power Pitch & Poster Sessions
Moderators: Rosa Tamara Branca, Ph.D. & Jürgen Machann, Ph.D.
17:00 Power Pitch Session
Modeling of Phase Errors for Quantification of Fatty Acid Composition Using Bipolar Multi-Echo MRI Manuel Schneider, M.Sc.
Friedrich-Alexander-Universität Erlangen-Nürnberg
Erlangen, Germany
Robust Fat-Water Separation by Iterative Phasor Refinement Hao Peng, Ph.D. Candidate
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Shenzhen, China
Effect of Multi-Parametric MR Images on Accuracy of U-Net Liver Segmentations Sara Saunders, M.S.
University of Minnesota
Minneapolis, MN, USA
Extending the Signal Models of the ISMRM Fat-Water Toolbox: Generalized Parameter Estimation in Multi-Echo Gradient-Echo-Based Chemical Species Separation Maximilian Diefenbach, M.Sc.
Technische Universität München
Munich, Germany
Reduction of Signal Loss Induced by Scanner Table Vibrations in High b-Value Diffusion-Weighted MRS of Lipids Dominik Weidlich, M.Sc.
Technische Universität München
Munich, Germany
Quantitative White Bone Imaging with SyNthetic Auto-Interpolated In-Phase (SNAP) MRI Timothy Bray, MBBChir, Ph.D.
University College London
London, England, UK
Development of a Dedicated Protocol for Fat Fraction Mapping in Obese Patients With Preliminary Findings in Bone Naomi Sakai, MBBChir, MA, MRCS
University College London
London, England, UK
Early Changes in Skeletal Muscle Composition Following Sleeve Gastrectomy Using Chemical Shift-Encoded Magnetic Resonance Imaging Naomi Sakai, MBBChir, MA, MRCS
University College London
London, England, UK
Psoas Volume & PDFF in Cancer Patients: Dynamics & Association with Severity of Cachexia Progression Daniela Franz, Dr. Med.
Technische Universität München
Munich, Germany
Comparison of Quantitative MRI Fat-Fraction Measurement in SIJ Joint on Different Scanner Platforms Alan Bainbridge, Ph.D.
University College London
London, England, UK
Multi-Site, Multi-Vendor & Multi-Platform Assessment of Accuracy of Quantitative Proton-Density Fat Fraction (PDFF) at 1.5 & 3 Tesla with a Standardized Spherical Phantom: Results from a Study by the RSNA QIBA PDFF Committee Houchun Hu, Ph.D.
Nationwide Children's Hospital
Columbus, OH, USA
Magnitude-Based Water Fat Separation with Resolved Ambiguity; Automated Quality Control Across Sites, Scanner Models, Vendors & Field Strengths Chloe Hutton, Ph.D.
Perspectum Diagnostics
Oxford, England, UK
Hyperpolarized [1–13C] Pyruvate MR Spectroscopy of Brain Metabolism in a Type 2 Diabetes Mouse Model Young-Suk Choi, Ph.D.
Yonsei University
Seoul, South Korea
Hypothalamic Obesity in Children & MRI Assessment Karuna Shekdar, M.D.
Children's Hospital of Philadelphia
Philadelphia, PA, USA
Introduction to Hypothalamic Obesity in Children: What MR Imagers Should Know Karuna Shekdar, M.D.
Children's Hospital of Philadelphia
Philadelphia, PA, USA
17:45 Poster Session
18:30 Adjourn
Dinner on Own
 
Day 3 – Wednesday, 24 July 2019
07:00 Registration & Speaker Upload Available
Breakfast on Own
07:50 Housekeeping & Announcements
08:00 Energy Balance in Over- & Under-nutrition: Past Lessons & Future Directions
(Introduction by P. Cozzone)
Christiani Jeyakumar Henry, Ph.D.
Clinical Nutrition Research Centre, A*Star
Singapore
08:30 Interactions Between Concepts of Pathogenesis & Goals Pursued by MRI & MRS (Introduction by H. Hu & S. Velan) Fritz Schick, M.D., Ph.D.
University of Tübingen
Tübingen, Germany
09:00 Break & Speaker Upload Available
 
Session 10: Big Data & "-omics": The Roles of Imaging
Moderators: Houchun Harry Hu, Ph.D. & Sambasivam Sendhil Velan, Ph.D.
09:30 Bridging Big Data & Imaging Studies for Precision Healthcare

Neerja Karnani, Ph.D.
Singapore Institute for Clinical Sciences
Singapore

10:00 Body Composition Analysis: Perspectives on Radiomics, Machine Learning & Big Data Magnus Borga, Ph.D.
Linköping University
Linköping, Sweden
10:30 Break for Change in Moderators
 
Session 11: Proffered Papers - Oral Session
Moderators: Jürgen Machann, Ph.D. & Holden Wu, Ph.D.
10:45 On the Definition of Sarcopenia in Non-Alcoholic Fatty Liver Disease (NAFLD): Results From the Large UK Biobank Imaging Study Jennifer Linge, M.Sc.
AMRA Medical
Linköping, Sweden
10:55 Change in Liver Proton Density Fat Fraction Following Treatment with Duodenal Mucosal Resurfacing in Patients with Type 2 Diabetes Mellitus: Preliminary Findings from an International Multi-Site Phase-II Trial Naomi Sakai, MBBChir, MA, MRCS
University College London
London, England, UK
11:05 Adverse Muscle Composition Within Non-Alcoholic Fatty Liver Disease (NAFLD) Is Associated with Increased Comorbidity: Results from the Large UK Biobank Imaging Study Jennifer Linge, M.Sc.
AMRA Medical
Linköping, Sweden
11:15 Spatially Resolved Lipid Droplet Size Mapping with a High b-Value Diffusion-Weighted 2D TSE Sequence in Phantoms, Human Adipose Tissue Samples & In Vivo Dominik Weidlich, M.Sc.
Technische Universität München
Munich, Germany
11:25 Automated & Standardized Whole-Body Adipose Tissue Segmentation in T1-Weighted FSE Thomas Kuestner, Dr.-lng.
University Hospital Tübingen
Tübingen, Germany
11:35 Fully Automated Deep Learning-Based Segmentation of Abdominal Visceral & Subcutaneous (Deep & Superficial) Adipose Tissue Depots in Children Yeshe Kway, B.Eng.
Hochschule Pforzheim
Pforzheim, Germany
11:45 Lunch & Speaker Upload Available
 
Session 12: Bone & Marrow Adipose Tissue
Moderators: Rosa Tamara Branca, Ph.D. & Dimitrios Karampinos, Ph.D.
13:00 Importance of Bone Marrow Adipose Tissue in Obesity & Metabolic Disorders Dimitrios Karampinos, Ph.D.
Technische Universität München
Munich, Germany
13:10 Quantitative Bone Marrow MRI & MRS: An Overview of Methods Stefan Ruschke, Ph.D.
Technical University of Munich
Munich, Germany
13:40 MRI of Bone Marrow Adipose Tissue & of the Relationship of Bone Marrow Adipose Tissue to Bone Matrix in Healthy Aging & Disease Roland Krug, Ph.D.
University of California, San Francisco
San Francisco, CA, USA
 
Session 13: Open Forum/Discussion
14:10 Workshop Summary & Discussion of Future Directions Houchun Harry Hu, Ph.D.
  &
Sambasivam Sendhil Velan, Ph.D.
15:00 Adjournment
 

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