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ISMRM Workshop on

Moving Forward with
Intravoxel Incoherent Motion Modeling
for Diffusion-Weighted MRI

An Attempt at Consensus

26-28 March 2024

Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Thank you for a great workshop!

Session recordings are available in the program.

Organizers

Chair:
Oliver J. Gurney-Champion, Ph.D.

Registration & Travel

Registration is Closed

Travel & Housing Information

Sustainability

ISMRM Sustainability Initiatives

Supporters & Declarations

Declarations of Financial Interests

Overview & Program

Workshop Overview

Intravoxel Incoherent Motion (IVIM) imaging provides a means for non-invasive simultaneous assessment of tissue water diffusion and perfusion characteristics by MRI without the need for an exogenous contrast agent. There is growing literature on IVIM supporting its value, with an exponential increase in the number of publications in the last decade. However, published results are to some extent contradicting, possibly due to methodological variations, thereby hindering the clinical adoption of the technique.

This workshop aims to bring together scientists and clinicians interested in IVIM to start the move towards consensus on the clinical and research use of IVIM. The workshop will include lectures, scientific presentations (orals and posters), and panel and roundtable discussions. Topics will span from the basics of the IVIM technique to common application in various body regions, to state-of-the-art methods for acquisition and processing, to validation and quality control, to future clinical applications, and novel developments such as flow-compensated IVIM. A significant portion of the workshop will be dedicated to activities aiming to facilitate starting the work on consensus—in particular, sessions enabling discussions in both larger and smaller groups.

Target Audience

The main topic is intravoxel incoherent motion (IVIM), and the workshop caters to those interested in IVIM. This workshop is designed for researchers (including Ph.D. candidates, postdocs, and professors), clinicians (e.g. radiologists), MR technologists, government regulatory experts, nonprofit and academic groups interested in IVIM, and members of the ISMRM Diffusion, ISMRM Perfusion and ISMRM Quantitative MR Study Groups.

Educational Objectives

Upon completion of this activity, participants should be able to:

  • Review the fundamentals of IVIM imaging, from theory to acquisition to processing to clinical implementation;
  • Describe the latest advances and insights in IVIM imaging;
  • Examine what diseases and disease sites are low-hanging fruit for IVIM;
  • Apply the use of IVIM in future research studies; and
  • Collaborate on the formation of IVIM guidelines and consensus statement.

Program

Day 1 - Tuesday, 26 March 2024 (4.0 CME Available)

07:00

Registration & Speaker Upload Available

Session 1: What Is Intravoxel Incoherent Motion?

Moderators: In-Young Choi, Ph.D. & Camila Munoz, Ph.D.

08:45

Welcome

Oliver J. Gurney-Champion, Ph.D.
Amsterdam University Medical Center
Amsterdam, The Netherlands

09:00

Denis Le Bihan, M.D., Ph.D
NeuroSpin
Gif-Sur-Yvette, France

09:30

David A. Reiter, Ph.D.
Emory University
Atlanta, GA, USA

10:00

Break & Speaker Upload Available

10:30

What Is Perfusion & How Does It Relate to What We Measure with IVIM?

Sila Kurugol, Ph.D.
Harvard Medical School & Boston Children's Hopsital
Boston, MA, USA

11:00

Ramesh Paudyal, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY, USA

11:30

Panel Discussion

12:00

Lunch & Speaker Upload Available

Session 2: What Acquisition Settings Should I Use?

Moderators: Frederik Bern Laun, Dr. rer. nat. & Mira Liu, Ph.D.

13:30

Paulien Voorter, M.Sc.
Maastricht University
Maastricht, The Netherlands

14:00

Diego Hernando, Ph.D.
University of Wisconsin-Madison
Madison, WI, USA

14:30

Susi Rauh, M.Sc.
Leiden University Medical Center
Leiden, The Netherlands

Proffered Papers - Oral Session

Moderators: Oscar Jalnefjord, Ph.D. & Gregory Simchick, Ph.D.

15:00

Gregory Simchick, Ph.D.
University of Wisconsin-Madison
Madison, WI, USA

15:10

Mohammed Salman Shazeeb, Ph.D.
University of Massachusetts Chan Medical School
Worcester, MA, USA

15:20

Camila Munoz, Ph.D.
Imperial College London
London, England, UK

15:30

Break & Speaker Upload Available

16:00

Consensus Statements

Mami Iima, M.D., Ph.D. &
Eric E. Sigmund, Ph.D.

16:30

Panel Discussion

17:00

Break & Speaker Upload Available

17:30

Power Pitch Session (No CME Available)

Moderators: Oliver J. Gurney-Champion, Ph.D. & Susi Rauh, M.Sc.

18:00

Poster Session (No CME Available)

19:00

Adjourn

19:30

Networking Dinner

Day 2 - Wednesday, 27 March 2024 (4.0 CME Available)

07:00

Registration & Speaker Upload Available

Session 3: What Will Be the First Clinical Applications?

Moderator: David Buckley, Ph.D.

08:00

Christian Federau, M.D.
AI Medical
Zollikon, Switzerland

08:30

Oncological & Functional Low-Hanging Fruit: Body

Alexandra Ljimani, M.D.
Institute of Diagnostic & Interventional Radiology
Duesseldorf, Germany

09:00

The Road to Clinical Introduction

James O'Connor, M.D., Ph.D.
The Institute of Cancer Research
London, England, UK

09:30

Break & Speaker Upload Available

Proffered Papers - Oral Session

Moderators: Christian Federau, M.D. & Denis Le Bihan, M.D., Ph.D.

10:00

Noa van der Knaap, M.Sc.
Maastricht University Medical Center
Maastricht, The Netherlands

10:30

Consensus Statements

Mami Iima, M.D., Ph.D. &
Eric E. Sigmund, Ph.D.

11:00

Panel Discussion

11:30

Lunch & Speaker Upload Available

Session 4: What Do We Practically Need To Get IVIM into the Clinic?

Moderators: Phil Lee, Ph.D. & Carlo Pierpaoli, M.D., Ph.D.

13:00

What Do We Need Technically To Get IVIM in the Clinic (What Do We Need from the Vendor?)

Martijn Froeling, Ph.D.
University Medical Center Utrecht
Utrecht, The Netherlands

13:30

Maria Ljungberg, Ph.D.
Sahlgrenska University Hospital
Gothenburg, Sweden

14:00

Naoki Ohno, Ph.D.
Kanazawa University
Kanazawa, Japan

14:30

Break & Speaker Upload Available

Proffered Papers - Oral Session

Moderators: Moti Freiman, Ph.D. & Jacobus Jansen, Ph.D.

15:10

Dibash Basukala, Ph.D.
New York University Langone Health
New York, NY, USA

15:30

Consensus Statements

Mami Iima, M.D., Ph.D. &
Eric E. Sigmund, Ph.D.

16:00

Panel Discussion

16:30

Power Pitch Session (No CME Available)

Moderators: Oliver J. Gurney-Champion, Ph.D. & Susi Rauh, M.Sc.

17:00

Poster Session (No CME Available)

18:00

Adjourn

Day 3 - Thursday, 28 March 2024 (2.0 CME Available)

08:00

Registration & Speaker Upload Available

Session 5: Modelling & Processing of IVIM Data

Moderators: Julia Stabinska, Ph.D. & Andreas Wetscherek, Ph.D.

09:00

Andreas Wetscherek, Ph.D.
The Institute of Cancer Research
London, England, UK

09:30

Preprocessing & Fitting Data

Peter T. While, Ph.D.
St. Olav's University Hospital
Trondheim, Norway

10:00

Advanced Processing Topics

Hui Gary Zhang, Ph.D.
University College London
London, England, UK

10:30

Break & Speaker Upload Available

Proffered Papers - Oral Session

Moderator: Walter Backes, Ph.D.

11:10

Misha Kaandorp, M.Sc.
St. Olav's Hospital
Trondheim, Norway

11:20

Louise Rosenqvist, M.Sc.
University of Gothenburg
Gothenburg, Sweden

11:30

Consensus Statements

Mami Iima, M.D., Ph.D. &
Eric E. Sigmund, Ph.D.

12:00

Panel Discussion

12:30

Lunch & Speaker Upload Available

Session 6: A Vendor's Perspective

Moderator: Carlo Pierpaoli, M.D., Ph.D.

14:00

IVIM in the Clinic: A Vendor's Perspective: What Do They Need from Us & What Can We Offer? (No CME Available)

Neil P. Jerome, Ph.D.
Siemens Healthineers
Trondheim, Norway

14:30

General Workshop-Wide Consensus Updated

15:00

Panel Discussion

15:30

Awards

16:00

Adjournment

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