ISMRM Scientific Workshop: 
Improving Cancer Treatment  with Advanced MR

Chaminade Conference Center, Santa Cruz, CA, USA
19-22 September 2010



  Sunday, 19 September
16:00-18:00 Registration
18:30-21:00 Opening Reception & Dinner
  Monday, 20 September
07:00-17:30 Registration
07:30-08:30 Breakfast
08:30 Welcome
08:45 Session I: Cancer Treatment Strategies, Chairs: Patrick Bolan, Ph.D. & Arend Heerschap, Ph.D.
08:45 MR Imaging & Improving the Management of Clinically Localized Prostate Cancer
Mack Roach, III, M.D., F.A.C.R.
University of California, San Francisco
San Francisco, CA, USA
09:15 Changing Role of Imaging for the Brain Tumor Patient - permission withheld
Susan M. Chang, M.D.
University of California, San Francisco
San Francisco, CA, USA
09:45 Proffered Papers
09:45 Monitoring Anti-Angiogenic Therapy of Glioblastoma Orthotopic Xenograft Models Using MRSI
Bob Hamans, M.Sc.
Radboud University, Nijmegen Medical Centre
Nijmegen, The Netherlands
10:00 Validation of Multiparametric Magnetic Resonance Imaging & Spectroscopy (DWI/MRSI) to Assess Prostate Cancer Aggressiveness
Thiele Kobus, M.Sc.
Radboud University, Nijmegen Medical Centre
Nijmegen, The Netherlands
10:15 Differential Responses to Cytotoxic & Cytostatic Agents by Metabolic & Functional Imaging End-Point
Natalie J. Serkova, Ph.D.
University of Colorado Health Services
Denver, CO, USA
10:30 Coffee Break
11:00 Session II: MR in Drug Research, Chair: Patricia E. Cole, M.D., Ph.D.
11:00 MR Imaging of Cancer Mechanisms: Examples from Glioblastoma
A. Gregory Sorensen, M.D.
Harvard Medical School
Charlestown, MA, USA
11:30 Therapeutic Targets & Biomarkers In Choline Phospholipid Metabolism of Cancer
Kristine Glunde, Ph.D.
Johns Hopkins School of Medicine
Baltimore, MD, USA
12:00 Proffered Papers
12:00 Effect of Hypoxia on Transport of Macromolecules in Breast Cancer Xenografts
Samanta M. Kakkad, M.Sc.
Johns Hopkins Medical Institute
Baltimore, MD, USA
12:15 HP 13C MRSI Allows Detection of mTOR Inhibition In Vivo in an Orthotopic Rodent Model of Glioblastoma
« William Negendank Award Winner - First Prize «
Myriam M. Chaumeil, Ph.D.
University of California, San Francisco
San Francisco, CA, USA
12:30 Lunch
14:00 Session III : Stratification of Tumors, Chairs: Ingrid S. Gribbestad, Ph.D. & Kirstie S. Opstad, Ph.D.
14:00 Stratifying Disease & Assessing Novel Treatments Using Magnetic Resonance
Martin O. Leach, Ph.D.
Institute of Cancer Research
Surrey, England, UK
14:30 Combining Metabolomics & Transcriptomics Using A New Harvesting Method For High Quality Prostate Cancer Tissue Samples
May-Britt Tessem, Ph.D.
Norwegian University of Science and Technology
Trondheim, Norway
14:45 Proffered Papers
14:45 In Vivo 1H-Magnetic Resonance Spectroscopy Reveals Biochemical Markers of Clinically Aggressive Meningiomas: Incorporation of 3D 1H-MRS Into A Neuronavigation System For Tumor Resection Advantage
Nina Z. Moore, M.S.E.
Barrow Neurological Institute
Phoenix, AZ, USA
15:00 Dynamic Susceptibility Contrast MRI & Proton MR Spectroscopy in Differentiating Genotypes of Oligodendrogliomas
Sanjeev Chawla, Ph.D.
University of Pennsylvania
Philadelphia, PA, USA
15:15 MRSI of the Prostate: Current Value & New Potential for Prostate Cancer Management
Tom W.J. Scheenen, Ph.D.
Radboud University, Nijmegen Medical Centre
Nijmegen, The Netherlands
15:30 Coffee Break
16:00 Session IV: MR in Clinical Routine Assessment Of Cancer Treatment, Chair: Michael V. Knopp, Ph.D.
16:00 New Developments in Clinical Imaging of Cancer - permission withheld
Heinz-Peter W. Schlemmer, M.D., Ph.D.
German Cancer Research Centre (DKFZ)
Heidelberg, Germany
16:30 Amide Proton Transfer (APT) Imaging of Pelvic Cancers
Guang Jia, Ph.D.
Ohio State University
Columbus, OH, USA
16:45 Proffered Papers
16:45 Apparent Diffusion Coefficient Values Predict Pathologic Response in Neoadjuvant Chemotherapy Treatment of Breast Cancer
Savannah C. Partridge, Ph.D.
University of Washington
Seattle, WA, USA
17:00 Diffusion Weighted MR Imaging Facilitates Pathological Response Prediction for Rectal Cancer After Neo-Adjuvant Therapy
Martijn Intven, M.D.
University Medical Centre Utrecht
Utrecht, The Netherlands
17:15 Phosphorus MR Spectroscopy Predicts Outcome To Conventional Chemotherapy In Patients With Untreated Diffuse Large B-Cell Lymphoma
Fernando Arias-Mendoza, M.D., Ph.D.
Columbia University
New York, NY, USA
17:30 Free Time
19:00 Dinner
  Tuesday, 21 September
07:00-17:30 Registration
07:30-08:30 Breakfast
08:30 « William G. Negendank Memorial Lecture: Targeting the Hallmarks of Cancer  «
Robert J. Gillies, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
Tampa, FL, USA
09:15 Coffee
09:30 Session V: MR & New Approaches For Cancer Treatments, Chairs: Ross J. Maxwell, Ph.D., & Tom Scheenen, Ph.D.
09:30 Rethinking MRI Data Acquisition Approaches & Contrasts
Michael Garwood, Ph.D.
University of Minnesota
Minneapolis, MN, USA
09:55 Using the Design of Nature's Own Nanoparticles as a Template to Create Multifunctional Imaging Probes
Willem M. Mulder, Ph.D.
Mount Sinai School of Medicine
New York, NY, USA
10:20 Proffered Papers
10:20 Silencing the Glycerophosphocholine Phosphodiesterase GDPD5 Reduced Breast Tumor Growth & Modulated Tumor Choline Phospholipid Metabolism
Maria D. Cao, M.Sc., B.Sc.
Norwegian University of Science & Technology
Trondheim, Norway
10:35 A New Method for Vascular Phenotyping of Brain Tumors Using Magnetic Resonance Microscopy
« William Negendank Award Winner - Third Prize «
Eugene Kim, B.S.E.
Johns Hopkins University School of Medicine
Baltimore, MD, USA
10:50 Improved Estimation of Glial Tumor Spread in a Mouse Model Using Local AIF DSC Perfusion MRI
Joel R. Garbow, Ph.D.
Washington University
St. Louis, MO, USA
11:05 Poster Session
13:00 Lunch
14:15 Session VI: Newly Emerging Cancer MR Biomarkers, Chairs: E. Jim Delikatny, Ph.D. & May-Britt Tessem, Ph.D.
14:15 Involvement of Human Choline Kinase Alpha & Beta In Carcinogenesis: A Differential Role In Lipid Metabolism & Biological Functions - permission withheld
Juan Carlos Lacal, Ph.D.
Instituto de Investigaciones Biomédica
Madrid, Spain
14:45 What Can 1H MRS Tell Us About Tumor Biology - Potential Biomarkers In Gliomas?
Kirstie S. Opstad, Ph.D.
St. George Hospital
London, England, UK
15:15 Proffered Papers
15:15 Evaluating the Prognostic Value of Breast Cancer Biomarker Candidates Identified by HR-MAS MRS Tissue Analysis
Beathe Sitter, Ph.D.
Norwegian University of Science & Technology
Trondheim, Norway
15:30 Hyperpolarized 13C MR Detection of Metabolic Changes in an Inducible MYC Mouse Model of Liver Cancer with Correlation to Enzyme Expression & Activity Assays
Simon Hu, M.Sc., B.Sc.
University of California, San Francisco
San Francisco, CA, USA
15:45 13C HR MAS MRS Reveals Differences in the Glucose Metabolism between Two Breast Cancer Xenograft Models with Different Gene Expression Patterns
Maria T. Grinde, M.Sc.
Norwegian University of Science & Technology
Trondheim, Norway
16:00 Coffee
16:30 Session VII: Working Group Sessions
The aim with the Working Group Sessions is to organize “in depth” discussion groups to talk about and share experience within selected topics. The working groups will be chaired by experienced scientists in the particular field.
  Working group 1 – Quantification of Contrast Uptake Discussion on Compartment Modelling Methods, Arterial Input Function, & Quantification vs. Empirical Analysis
Chair: Alan Jackson, Ph.D.
Discussion on compartment modelling methods, arterial input function, quantification vs. empirical analysis
  Working group 2 – Design of Animal Protocols Practical Considerations in Experimental Design, Imaging Sequences,
Coils & Animal Beds
Chair: Arend Heerschap, Ph.D.
Practical considerations in experimental design, imaging sequences, coils and animal beds
  Working group 3 – Quantification of MRS: How to Perform Quantitative MRS Experiments, Different Methods for Quantitative Analysis & Quantification vs. Semiquantitative Data Assessment
Chair: John Kurhanewicz, Ph.D.
How to perform quantitative MRS experiments, different methods for quantitative analysis, quantification vs. semi-quantitative data assessment
  Working group 4 – MR Diffusion for Treatment Response Choice of Sequences, B-Values, Standardisation of Protocols, & Data Analysis
Chair: Harish Poptani, Ph.D.
Choice of sequences, b-values, standardisation of protocols, data analysis
  Working group 5 – Advanced MRS Challenges with High-Field MRS, Concepts for Fast MRSI  & Importance of Coil Design
Chairs: Patrick J. Bolan, Ph.D. & Tom W.J. Scheenen, Ph.D.
Challenges with high-field MRS, concepts for fast MRSI, importance of coil design
17:30 Free time
19:00-23:00 Dinner
  Wednesday, 22 September
07:30-12:00 Registration
07:30-08:30 Breakfast
08:30 Session VIII: Multimodal Imaging For Improved Cancer Treatment, Chairs: Kyrre Emblem, Ph.D. & Susan M. Noworolski, Ph.D.
08:30 MRI in the Development of Antiangiogenic & Vascular Targeting Agents
Alan Jackson, Ph.D.
University of Manchester
Manchester, England, UK
09:00 Multi-Modal Imaging of Cancer Cachexia
Marie-France Penet, Ph.D.
Johns Hopkins School of Medicine
Baltimore, MD, USA
09:15 Proffered Papers
09:15 Serial Dynamic Contrast-Enhanced MRI & Dynamic 18F-FDG PET Breast Tumor Measures in Women Undergoing Neoadjuvant Chemotherapy
Savannah C. Partridge, Ph.D.
University of Washington
Seattle, WA, USA
09:30 “Multi-scale” Imaging of Angiogenesis in a Breast Cancer Model
Jana Cebulla, B.Sc.
Johns Hopkins University
Baltimore, MD, USA
09:45 Reproducibility of DWI & Correlation with Semi-Quantative FDG-PET in Liver Metastases of Colorectal Cancer
Linda Heijmen, M.D.
Radboud University, Nijmegen Medical Centre
Nijmegen, The Netherlands
10:00 Coffee Break
10:30-12:00 Session IX: How To Present MR Information To Clinicians, Chairs: Franklyn A. Howe, D.Phil. & Savannah C. Partridge, Ph.D.
10:30 Clinical MRI: How Do We Move Beyond the Visual Interpretation? - Strategies & Challenges
Michael V. Knopp, M.D., Ph.D.
Ohio State University
Columbus, OH, USA
11:00 A Pattern Recognition Approach For The Differentiation Of Brain Tumors Based On MRI & MRSI
Jan Luts, Ph.D.
Katholieke Universiteit Leuven
Leuven, Belgium
11:15 Proffered Papers
11:15 Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models
Lu Jiang, Ph.D.
Johns Hopkins University School of Medicine
Baltimore, MD, USA
11:30 A Potential Mechanism for Measuring Tumor Ionic Microenvironment: MR Signal Delay
Yongxian Qian, Ph.D.
University of Pittsburgh
Pittsburgh, PA, USA
11:45 Dynamic Contrast Enhanced (DCE) & Diffusion Weighted MRI in Monitoring Treatment Response of Head & Neck Cancer
Harish Poptani, Ph.D.
University of Pennsylvania
Philadelphia, PA, USA
12:00 Adjourn/Lunch/Departures

The International Society for Magnetic Resonance in Medicine is accredited by 
the Accreditation Council for Continuing Medical Education to 
provide continuing medical education for physicians.