PROGRAM
Educational Objectives:
Upon completion of this workshop, participants should be able to:
  • Identify the MR correlates of the various pathological substrates of MS;
  • Apply and interpret structural and functional MR-based techniques to study the characteristics and evolution of MS-related damage;
  • Describe the "state of the art" knowledge as regards the relationship between inflammation and neurodegeneration in MS;
  • Diagnose MS vs. other demyelinating diseases by combining clinical, laboratory, and MR-derived information;
  • Design appropriate MR protocols to help in the differential diagnosis of MS vs. other demyelinating diseases.

Thursday, 9 October 2003
Understanding In Vivo the Various Pathological Substrates of MS Using MR Technology
09:15 Welcome and Introduction
Massimo Filippi, M.D., and Giuseppe Scotti, M.D., Scientific Institute H. San Raffaele, Milan, Italy
Plenary Session I:
Chairs:  Douglas L. Arnold, M.D., Montréal Neurological Institute, Montréal, PQ, Canada, and Neil J. Scolding, M.D., Frenchay Hospital, Bristol, England, UK
  Blood Brain Barrier Increased Permeability
09:30 Basic Aspects
Pierre O. Couraud, Ph.D., Institut Cochin de Genetique Moleculaire, Université Paris V, Paris, France
09:50 MR Assessment
Jack H. Simon, M.D., Ph.D., University of Colorado Health Science Center, Denver, CO, USA
  Acute Inflammation
10:10 Basic Aspects
Gianvito Martino, M.D., Scientific Institute H. San Raffaele, Milan, Italy
10:30 MR Assessment
Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France
  "Low-Burning/Grade" Inflammation
10:50 Basic Aspects
Dr. Clive P. Hawkins, North Staffordshire Hospital Royal Infirmary, Stoke-on-Trent, England, UK
11:10 MR Assessment
Marco Rovaris, M.D., Scientific Institute H. San Raffaele, Milan, Italy
11:30 Break
Plenary Session I (continued):
Chairs:  Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France, and Jack H. Simon, M.D., Ph.D., University of Colorado Health Science Center, Denver, CO, USA
  Demyelination/Remyelination and Astrogliosis
11:50 Basic Aspects
Neil J. Scolding, M.D., Frenchay Hospital, Bristol, England, UK
12:10 MR Assessment
Frederik Barkhof, M.D., Ph.D., VU Medical Centre, Amsterdam, The Netherlands
  Axonal Dysfunction/Loss
12:30 Basic Aspects
Samuel W. Ludwin, M.D., Queen's University, Kingston, ON, Canada
12:50 MR Assessment
Douglas L. Arnold, M.D., Montréal Neurological Institute, Montréal, PQ, Canada
  Cortical Plasticity
13:10 Basic Aspects
Richard S. J. Frackowiak, F.R.C.P., Institute of Neurology-UCL, London, England, UK
13:30 MR Assessment
Massimo Filippi, M.D., Scientific Institute H. San Raffaele, Milan, Italy
13:50 Lunch Break
Proffered Papers (15:05-16:15)
Chairs:  Richard S. J. Frackowiak, F.R.C.P., Institute of Neurology-UCL, London, England, UK, and Prof. Jerry S. Wolinsky, Department of Neurology, University of Texas, Health Science Center, Houston, TX, USA
15:05 Hemodynamic Impairment in Multiple Sclerosis Lesions: Dynamic Susceptibility Contrast Perfusion MR Imaging
Yulin Ge
15:15 Microvascular Abnormality in Relapsing-Remitting Multiple Sclerosis: Perfusion MR Findings in the Normal Appearing White Matter
Meng Law
15:25 Lesion Evolution via MRI Intensity Dynamics -- A Quest for Pathological Specificity in Multiple Sclerosis
D. Meier
15:35 Myelin Water Imaging in Multiple Sclerosis: Quantitative Correlations with Histopathology
Corneila Laule
15:45 Early in vivo characterization of relapsing experimental auto-immune encephalomyelitis lesions by macrophage cellular imaging (USPIO) predicts late occurrence of axonal loss
Bruno Brochet
15:55 A quantitative magnetization transfer study of edema and demyelination in chronic T1 black holes
Ives Levesque
16:10 Metabolic Activity in Non-enhancing T1 Hypo- and Iso-intense Lesions and Normal-Appearing White Matter in Relapsing-Remitting MS
Oded Gonen
16:15 Break
16:30 Workshops
  MRI and Inflammation
Chairs:  Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France, and Jack H. Simon, M.D., Ph.D., University of Colorado Health Science Center, Denver, CO, USA
  MRI and Demyleination
Chairs:  Oded Gonen, Ph.D., NYU School of Medicine, New York, NY, USA, and Prof. Jerry S. Wolinsky, Department of Neurology, University of Texas, Health Science Center, Houston, TX, USA
  MRI and Axonal Loss/Dysfunction
Chairs:  Douglas L. Arnold, M.D., Montréal Neurological Institute, Montréal, PQ, Canada, and Massimo Filippi, M.D., Scientific Institute H. San Raffaele, Milan, Italy
  MRI Study Protocols for Other WM Disorders
Chairs:  Franz Fazekas, M.D., Karl-Franzens University, Graz, Austria, and Mario Savoiardo, M.D., Istituto Nazionale Neurologico, 'C. Best," Milan, Italy
17:50 Adjournment

Friday, 10 October 2003
From Inflammation to "Neurodegeneration"
Plenary Session II:
Chairs:  Giancarlo Comi, M.D., Scientific Institute H. San Raffaele, Milan, Italy, and Oded Gonen, Ph.D., NYU School of Medicine, New York, NY, USA
  Can We Agree on Definitions?
09:15 Inflammation
Reinhard Hohlfeld, M.D., Klinikum Grosshadern, Munich, Germany
09:35 "Neurodegeneration"
Peter Rieckmann, M.D., Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
  Mechanisms
09:55 Basic Aspects
Bruce D. Trapp, M.D., Department of Neurosciences, The Cleveland Clinic, Cleveland, OH, USA
10:15 Immunological Aspects
Hans Peter Hartung, M.D., Heinrich-Heine-Universität, Düsseldorf, Germany
10:35 "Neurodegeneration" Without Inflammation
Catherine Lubetzki, M.D., Hôpital de la Salpetrière, Paris, France
10:55 Break
Plenary Session II (continued):
Chairs:  Massimo Filippi, M.D., Scientific Institute H. San Raffaele, Milan, Italy, and Hans Peter Hartung, M.D., Heinrich-Heine-Universität, Düsseldorf, Germany
  Clinical Aspects - Importance and Measures
11:15 Inflammation
Fred D. Lublin, M.D., Mount Sinai School of Medicine, New York, NY, USA
11:35 "Neurodegeneration"
Giancarlo Comi, M.D., Scientific Institute H. San Raffaele, Milan, Italy
  MRI Aspects
11:55 What We Have Learned from the Application of MTR and Diffusion
Matilde Inglese, M.D., NYU School of Medicine, New York, NY, USA
12:15 What We Have Learned from the Application of MRS
Andrea Falini, M.D., Scientific Institute H. San Raffaele, Milan, Italy
12:35 What We Have Learned from the Application of Perfusion
Waqar Rashid, M.D., Institute of Neurology-UCL, London, England, UK
12:55 Lessons from MR-Monitored Clinical Trials
Franz Fazekas, M.D., Karl-Franzens University, Graz, Austria
13:15 Lunch Break
Proffered Papers (14:30-15:50)
Chairs:  Andrea Falini, M.D., Scientific Institute H. San Raffaele, Milan, Italy, and Bruce D. Trapp, M.D., Department of Neurosciences, The Cleveland Clinic, Cleveland, OH, USA
14:30 Magnetization Transfer Ratio and Brain Atrophy Following Corticosteroids in Multiple Sclerosis:  Short-term Changes and Long-term Implications
R.J. Fox
14:40 Neuronal Cell Injury Precedes Brain Atrophy in Multiple Sclerosis
Oded Gonen
14:50

Multi-slice echo planar spectroscopic MR imaging provides both WBNAA estimates and measurements of metabolites in specific brain areas in multiple sclerosis
Henrik K. Mathiesen
15:00 Evidence of Progressive Brain Tissue Destruction
Bruno Brochet
15:10 The Evolution of Multiple Sclerosis Lesions: A Multiparameter MR Study
Cornelia Laule
15:20 Diffuse Structural Brain Abnormalities Detected by MR Correlate with Cognitive Dysfunction in early RR MS
Bruno Brochet
15:30 In vivo Assessment of glutamate in MS with proton MR spectroscopy at 3T
Radhika Srinivasan
15:40 A 3-year longitudinal monthly study on the evaluation of the effect of Interferon Beta in multiple sclerosis
Francesca Bagnato
15:50 Break
16:20 Workshops
  MRI and Inflammation
Chairs: Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France, and Jack H. Simon, M.D., Ph.D., University of Colorado Health Science Center, Denver, CO, USA
  MRI and Demyelination
Chairs:  Oded Gonen, Ph.D., NYU School of Medicine, New York, NY, USA, and Prof. Jerry S. Wolinsky, Department of Neurology, University of Texas, Health Science Center, Houston, TX, USA
  MRI and Axonal Loss/Dysfunction
Chairs:  Douglas L. Arnold, M.D., Montréal Neurological Institute, Montréal, PQ, Canada, and Massimo Filippi, M.D., Scientific Institute H. San Raffaele, Milan, Italy
  MRI Study Protocols for Other WM Disorders
Chairs:  Franz Fazekas, M.D., Karl-Franzens University, Graz, Austria, and Mario Savoiardo, M.D., Istituto Nazionale Neurologico "C. Besta," Milan, Italy
17:50 Adjournment
Saturday, 11 October 2003
MR Imaging of MS Related Diseases
Plenary Session III
Chairs:  Isabelle Berry, M.D., Ph.D., Hôpital Rangueil, Toulouse, France, and Franz Fazekas, M.D., Karl-Franzens University, Graz, Austria
09:15 Differential Diagnosis: General Issues
Giuseppe Scotti, M.D., Scientific Institute H. San Raffaele, Milan, Italy
09:35 Spinal Cord Imaging (Differential Diagnosis)
Dr. Geert J. Lycklama a' Nijeholt, Polikliniek Vrije Universiteit Hospital, Amsterdam, The Netherlands
09:55 Optic Nerve Imaging (Differential Diagnosis)
Mario Mascalchi, M.D., Università di Firenze, Florence, Italy
10:15 Clinically Isolated Syndromes Suggestive of MS
Xavier Montalban, M.D., Vall d'Hebron Hospital, Barcelona, Spain
10:35 Primary Progressive MS
Alan J. Thompson, M.D., Institute of Neurology-UCL, London, England, UK
10:55 Acute Disseminated Encephalo-Myelitis
Bruno Brochet, M.D., CHU Pellegrin, Bordeaux, France
11:15 Break
Plenary Session III (continued)
Chairs:  Giuseppe Scotti, M.D., Scientific Institute H. San Raffaele, Milan, Italy, and Alan J. Thompson, M.D., Institute of Neurology-UCL, London, England, UK
11:30 Devic's Neuromyelitis Optica
Maria A. Rocca, M.D., Scientific Institute H. San Raffaele, Milan, Italy
11:50 Leber's Hereditary Optic Neuropathy
Matilde Inglese, M.D., NYU School of Medicine, New York, NY, USA
12:10 Balò/Pseudotumor
Isabelle Berry, M.D., Ph.D., Hôpital Rangueil, Toulouse, France
12:30 Schilder/Marburg
Fabio Triulzi, M.D., Ospedale dei Bambini V. Buzzi, Milan, Italy
12:50 Adrenoleukodistrophy
Mario Savoiardo, M.D., Istituto Nazionale Neurologico "C. Besta," Milan, Italy
13:10 Adult-Onset Leukodistrophy
Alberto Bizzi, M.D., Istituto Nazionale Neurologico "C. Best," Milan, Italy
13:30 PML/HIV
Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France
13:50 Lunch Break
Proffered Papers (15:10-16:00)
Chairs:  Frederik Barkhof, M.D., Ph.D., VU Medical Centre, Amsterdam, The Netherlands
15:10 Role of Proton MR Spectroscopic Imaging in the Evaluation of Adrenomyeloneuropathy: A Genetic White Matter Disease
Prachi Dubey
15:20 In vivo studies of Dg-DTPA conjugated with 9.2.27 monoclonal antibody and Gd-porphyrins as cancer-specific MR imaging contrast agents
D. Shabazi-Gahrouei
15:30 Diffusion Tensor Imaging Detects and Differentiates Axon and Myelin Degeneration in Mouse Optic Nerve
Sheng-Kwei Song
15:40 In vivo Anistrophy and Diffusivity of the Optic Nerve using ZOOM-EPI
Claudia Wheeler-Kingshott
15:50 Quantification of Myelin Water in Human Cervical Spinal Cord in vivo
Yijing Wu
16:10 Workshops
  MRI and Inflammation
Chairs:  Vincent Dousset, M.D., CHU Pellegrin, Bordeaux, France, and Jack H. Simon, M.D., Ph.D., University of Colorado Health Science Center, Denver, CO, USA
  MRI and Demyelination
Chairs: Oded Gonen, Ph.D., NYU School of Medicine, New York, NY, USA, and Prof. Jerry S. Wolinsky, Department of Neurology, University of Texas, Health Science Center, Houston, TX, USA
  MRI and Axonal Loss/Dysfunction
Chairs:  Douglas L. Arnold, M.D., Montréal Neurological Institute, Montréal, PQ, Canada, and Massimo Filippi, M.D., Scientific Institute H. San Raffaele, Milan, Italy
  MRI Study Protocols for Other WM Disorders:
Chairs:  Franz Fazekas, M.D., Karl-Franzens University, Graz, Austria, and Mario Savoiardo, M.D., Istituto Nazionale Neurologico "C. Besta," Milan, Italy
16:50 Workshop Summary
Workshop Chairs
17:35 Closing Remarks
Massimo Filippi, M.D., and Giuseppe Scotti, M.D., Scientific Institute H. San Raffaele, Milan, Italy
17:50 Adjournment