Educational Objectives
Upon completion of this workshop, participants should be able to:

  • Identify the assumptions and limitations of the DSC-MRI and ASL perfusion imaging techniques;
  • Describe the different methods to measure the arterial input function, and the "state-of-the-art" techniques to perform the deconvolution required for quantification of CBF using DSC-MRI;
  • Describe the various labeling approaches used in ASL to measure cerebral perfusion, as well as their relative advantages and disadvantages;
  • Apply and interpret DSC-MRI and ASL, both in a clinical setting and in basic research studies;
  • Design the appropriate MR acquisition protocols and select the suitable data modeling to assess cerebral perfusion in various applications.

Thank you!
The Workshop Organizing Committee would like to acknowledge the assistance of David Alsop, Ph.D., and Eric Wong, M.D., Ph.D., in reviewing the abstracts submitted to this workshop.

Sunday, 21 March 2004

9:00 Registration and Poster Set-up
9:30 Welcome and Introduction
Oral Session 1: DSC-MRI: Theoretical Basis and Assumptions
Moderators:  Jianhiu Zhong, Ph.D., and Thomas E. Conturo, M.D., Ph.D.
9:45 Transverse Relaxation Effect of Contract Agent: A Crucial Issue for Quantitative Measurements
Valerij G. Kiselev, Ph.D., Freiburg University Hospital, Freiburg, Germany
10:05 Questions
Proffered Talks
10:10 Quadracity and hematocrit dependence of ΔR2* AIF signals at 3T: A blood phantom study under physiologic conditions, E. Akbudak
10:25 Theoretical analysis of internal accuracy of perfusion measurements at 1.5T and 3T, B.F. Jensen
10:40 Improving the reliability of tumor CBF measurements obtained in the presence of contrast extravasation, C.C. Quarles
10:55 Absolute cerebral blood volume mapping using high contrast agent relaxivity: rapid steady state T1 method, A. Barbacaru
11:10 Coffee Break Sponsored by Siemens
Oral Session 2: ASL Theoretical Basis and Labeling Approaches
Moderators:  Emmanuel L. Barbier, Ph.D., and Alan Connelly, Ph.D.
11:30 Arterial Spin Labeling Strategies for Perfusion Imaging of the Brain
David Alsop, Ph.D., Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
11:50 Pulsed ASL
Eric C. Wong, Ph.D., M.D., University of California at San Diego, La Jolla, CA, USA
12:10 Questions
Proffered Talks
12:20 A simple model of double adiabatic inversion efficiency, H. Michael Gach
12:35 Improving the quantification of continuous ASL: Simulations of adiabatic inversion efficiency using velocity measurements from phase contrast MRA, R.L. O'Gorman
12:50 Flow territory mapping of the cerebral arteries with regional perfusion MRI (RPI), J. Hendrickse
13:05 Lunch Sponsored by Pfizer
14:30 Poster Session 1: DSC MRI Posters Sponsored by Tyco Healthcare/Mallinckrodt
16:10 Break
Oral Session 3: ASL Data Analysis and Quantification
Moderators:  Frank Q. Ye, Ph.D., and John A. Detre, M.D.
16:30 Quantifying CBF with Arterial Spin Labeling
Richard B. Buxton, Ph.D., University of California at San Diego, La Jolla, CA, USA
16:50 Quantification of ASL Perfusion Images - Two Compartment Models
Laura M. Parkes, Ph.D., University of Nijmegen, Nijmegen, The Netherlands
17:10 Questions
Proffered Talks
17:20 The influence of transit times on dual-coil CASL in humans, H. E. Möller
17:35 Pulsed ASL labeling parameter optimization for an elderly population, A. Campbell
17:50 Cerebral hypoperfusion in Alzheimer's disease and mild cognitive impairment and age-related prolongation of perfusion transit times by ASL MRI, N. Johnson
18:05 Adjournment

Monday, 22 March 2004

Oral Session 4: DSC-MRI: Arterial Input Function Measurement
Moderators:  David C. Alsop, Ph.D., and Fernando Calamante, Ph.D.
9:30 Arterial Input Functions for Dynamic Susceptibility Contrast MRI: Requirements and Signal Options
Thomas E. Conturo,
M.D., Ph.D., Washington University, St. Louis, Missouri, USA
9:50 Measurement of the Arterial Input Function with Gradient Echo Sequences
Matthias J.P. van Osch, Ph.D., University Medical Center Utrecht, Utrecht, The Netherlands
10:10 Questions
Proffered Talks
10:20 Optimal dose determination for Δ-R2* and Δ-phi arterial input functions using simulations, M. S. Kotys
10:35 Semi-automated PWI analysis using vascular territory specific local arterial input functions, S. Christensen
10:50 Defining a local arterial input function for perfusion MRI using independent component analysis, F. Calamante
11:05 Coffee Break Sponsored by Sun Microsystems
Oral Session 5: DSC-MRI: Deconvolution and Quantification
Moderators:  Ona Wu, Ph.D., and Jussi Perkiö

Cerebral Perfusion Imaging by Bolus Tracking
Leif Østergaard, M.D., Ph.D., Aarhus University Hospital, Aarhus, Denmark

11:45 Bolus Dispersion Issues Related to the Quantification of Perfusion MRI Data
Fernando Calamante, Ph.D., University College London, London, England, UK
12:05 Questions
Proffered Talks
12:15 Nonlinear stochastic regularization to characterize tissue residue function from bolus-tracking MRI images, F. Zanderigo
12:30 More advantages of GDP compared to SVD for deconvolution, I. K. Andersen
12:45 Improved discrimination of salvageable and irreversibly infarcted tissue in acute stroke using perfusion weighted MRI and delay-insensitive deconvolution methods, O. Wu
13:00 Successful quantification of cerebral blood flow by T2* MRI, G.C. Newman
13:15 Lunch Sponsored by Siemens
Oral Session 6: DSC-MRI and ASL: Validity Testing, Comparison Studies, and Other Methods
Moderators:  Peter B. Barker, D.Phil, and Richard B. Buxton, Ph.D.

Validation Studies Across Modality: Pitfalls, DSC-MRI Validation Studies
Leif Østergaard, M.D., Ph.D., Aarhus University Hospital, Aarhus, Denmark

15:00 ASL: Validity Testing and Comparison Studies
James R. Ewing, Ph.D., Henry Ford Hospital and Health Science Center, Detroit, MI, US
15:20 Questions
Proffered Talks
15:30 Quantitative perfusion measurements in the cortex at 1.5 and 3.0 Tesla under normo-and hypercapnic conditions, U. Noeth
15:45 Potential and limitations of oxygen-17 MR perfusion measurements, G. D. Mateescu
16:00 Hyperpolarized 129Xe NMR: Another way for absolute MR quantification of tissue perfusion, J-N. Hyacinthe
16:15 Poster Session 2 and Break:  ASL Posters  Sponsored by Pfizer
17:55 Adjournment

Tuesday, 23 March 2004

Oral Session 7: DSC-MRI and ASL: Basic Research Applications of Perfusion MRI
Moderators:  Alexander J. S. de Crespigny, Ph.D., and David G. Gadian, M.D., D.Phil
9:30 Perfusion-Based fMRI: Insights from Animal Models
Afonso C. Silva, Ph.D., National Institutes of Health, Bethesda, MD, USA
9:50 Arterial Spin Labeling in Small Animals - Methods and Applications to Experimental Cerebral Ischemia
David L. Thomas, Ph.D., University College London, London, England, UK
10:10 Questions
Proffered Talks
10:20 MRI measurements of haemodynamics following chronic bilateral common carotid artery occlusion in the rat, M. Choy
10:35 Combining BT-MRI and CASL enables in-vivo phenotyping of genetically engineered mouse models for amytrophic lateral sclerosis, G. Vanhoutte
10:50 Perfusion-based high-resolution fMRI in the primate brain using a novel vertical large-bore 7 Tesla setup, J. Pfeuffer
11:05 Using Gd-DTPA washout dynamics to elucidate sources of BOLD latency, R. M. Birn
11:20 Correlation between EEG alpha-activity and brain perfusion - a simultaneous EEG and arterial spin-labeling investigation, T. E. Lund
11:35 Coffee Break Sponsored by SurgiVet, Inc.
Oral Session 8: DSC-MRI and ASL: Clinical Applications of Perfusion MRI
Moderators:  Jeffry R. Alger, Ph.D., and Cecile B. Grandin, M.D.

Bringing it All Together: Perfusion MRI in Acute Stroke
A. Gregory Sorenson, M.D., Massachusetts General Hospital, Boston, MA, USA

12:15 Clinical Applications of Arterial Spin Labeling MRI of the Brain
David Alsop, Ph.D., Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
12:35 Questions
Proffered Talks
12:45 Age dependent variation of cerebral perfusion assessed by continuous arterial spin labeling, L. Biagi
13:00 Non-invasive perfusion measurements in term neonates and premature infants using arterial spin labeling, M. J. Miranda
13:15 Evaluation of brain tumor neovascularity using gradient-echo/spin-echo DSC: Biophysical issues and implications for tumor biology in patients, K.M. Schmainda
13:30 Break
14:55 Poster Session 3:  All DSC-MRI and ASL Posters
16:35 Coffee Break Sponsored by Siemens
Oral Session 9: DSC-MRI and ASL: New imaging methods for perfusion imaging
Moderators:  Peter Jezzard, Ph.D., and Eric C. Wong, M.D., Ph.D.

New Imaging Methods for Perfusion Imaging
Jeff H. Duyn, Ph.D., National Institutes of Health, Bethesda, MD, USA

17:15 Questions
Proffered Talks
17:25 Single-shot susceptibility-insensitive whole brain 3D perfusin imaging with ASL, G. Duhamel
17:40 Efficient 3D perfusion measurement using single-shot 3D-GRASE, M. Guenther
17:55 Whole brain CASL perfusion MRI at 3T using a 16 channel receiver coil array, S.L. Talagala
18:05 Workshop Summary and Closing Remarks
18:20 Adjournment