Educational Objectives:
Upon completion of this workshop, participants should be able to:
  • Appraise the research fields of molecular and cellular imaging and their (potential) impact in diagnosis and therapy of the future;
  • Describe several new technologies in molecular and cellular imaging targeted to specific biological pathways;
  • Explain the role of the major imaging modalities in cellular and molecular imaging;
  • Describe the (potential) role of molecular imaging in advanced therapies, notably gene therapy;
  • Describe the (potential) role of cellular imaging in cell repair therapy, notably via stem cells;
  • Summarize the basic principles of imaging of key biological processes such as angiogenesis, apoptosis, inflammation.
17:00 - 19:00 Registration
Session I: Contrast Agents for Molecular Imaging
08:30 Welcome and Introduction
08:45 Molecular Imaging Inaugural Lecture
Juri Tjuvavev, M.D., Ph.D., Memorial Sloan-Kettering Cancer Center, New York, New York, USA
09:15 PET/SPECT Contrast Agents
Helmut Maecke
, M.D., University of Basel, Basel, Switzerland
09:45 Paramagnetic Lanthanide Chelates in MRI: from Extracellular Contrast Agents to Probes for Molecular Imaging
Silvio Aime, Ph.D., University of Torino, Torino, Italy
10:15 Break
10:45 Combined MRI/PET/SPECT Contrast Agents
Frank Roesch
, M.D., University of Mainz, Mainz, Germany
11:15 Ultrasound Contrast Agents
Samuel Wickline, M.D., Washington University School of Medicine, St. Louis, Missouri, USA
11:45 Optical Contrast Agents
12:00 -13:30 Break
14:00 Poster Viewing
Session II: Targeted Pathways and Physiological Processes
16:00 New Marker Gene/Marker Substrate Combinations
Uwe Haberkorn, M.D., University of Heidelberg, Heidelberg, Germany
16:30 Imaging Gene Expression with MRI
James Basilion, Ph.D., Massachusetts General Hospital, Boston, Massachusetts, USA
17:00 Image-Guided Gene Therapy
Andreas Jacobs, M.D., Max-Planck-Institut, Köln, Germany
17:30 Image Guided Control of Transgene Expression
Chrit Moonen, Ph.D., Université Victor Segalen Bordeaux 2, Bordeaux, France
18:00 Adjournment

MONDAY, 30 JUNE 2003

Session III: Cancer
  Diagnostics Related


Imaging Tumor Proliferation
Kenneth Krohn, Ph.D., University of Washington, Seattle, Washington, USA
09:00 Functional and Molecular Imaging of Vascular Remodeling - Angiogenesis and Lymphangiogenesis
Michal Neeman, Ph.D., Weizmann Institute, Rehovot, Israel
09:30 Imaging of Neoangiogenesis for Monitoring Treatment
Pat Price, Ph.D., University of Manchester, Manchester, England, UK
10:00 Break
  Therapy Related
10:30 Tumor Targeting with Radiolabeled Peptides
Hans-Jürgen Wester, Ph.D., Technical University Munich, Munich, Germany
11:00 Optical Imaging of Metastatic Tumor Models
Clemens Lowik, Ph.D., University of Leiden Medical Center, Leiden, The Netherlands
  Poster Presentations
11:30 Imaging of T cell Activation Mediated by Artificial Chimeric Anti-CEA Receptor
Vladimir Ponomarev, M.D., Ph.D., et al., Memorial Sloan-Kettering Cancer Center, New York, NY, USA
11:42 Synthesis and Production of 18F-Labeled Radiotracers FIAU and FEAU for Imaging of Triple Modality Reporter Gene nesHSV1-tk/GFP/Luciferase Expression In Vivo
Michael Doubrovin, et al., Memorial Sloan-Kettering Cancer Center, New York, NY, USA
11:54 MRI and Fluorescence Microscopy of Vascular Permeability and Maturation: Implications of Tumor and Stroma Expression of VEGF and Angiopoietins-1,2 on Tumor Vascular Heterogeneity
Assaf Gilead, M.Sc., et al., The Weizmann Institute of Science, Rehovot, Israel
12:06 In Vivo Cellular imaging of Magnetically Labelled Hybridomas in the Spleen on a 1.5T Clinical MRI System
Pierre Smirnov, et al., Faculté de Médecine Necker, Laboratoire de Recherche En Imagerie, Paris, France
12:18 Break
Session IV: Inflammatory and Degenerative Diseases
  Diagnostics Related
14:00 Imaging of Macrophage Activity
Nicolas Grenier, M.D., Ph.D., Groupe Hospitalier Pellegrin, Bordeaux, France and Vincent Dousset, M.D., Ph.D., CHU Pellegrin, Bordeaux, France
14:30 Imaging Atherosclerotic Plaque Activity
Michael Schäfers, M.D., University of Münster, Münster, Germany
15:00 Imaging of Pathophysiological Processes in Parkinson's Disease
David Brooks, M.D., Hammersmith Hospital, London, England, UK
15:30 Alzheimer's Plaque Imaging
Dr. Bengt
Långström, University of Uppsala, Uppsala, Sweden
16:00 Break
  Therapy Related
16:30 Imaging Guided Therapy of Parkinson's Disease
Rüdiger Hilker, M.D., Max-Planck-Institut, Köln, Germany
17:00 Pharmaceutical Perspectives
Martin Rausch, Ph.D., Novartis Pharma AG, Basel, Switzerland
17:30 Adjournment


Session V: Stem Cells and Progenitors


Stem Cells and Progenitors: General Lecture
Pierre Charbord, Laboratoire d'Hématopo
ïèse, Tours, France
  Diagnostics/Understanding Underlying Processes
09:00 Stem Cell Imaging and Gene Expression
Kishore K. Bhakoo, Ph.D.,
MRC Clinical Sciences Center, London, England, UK
09:30 Tracking of Magnetically Labeled Progenitors and Stem Cells
Jeff Bulte, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
10:00 Break
10:30 In Vivo MRI of Stem Cell Migration Following Stroke
Mathias Hoehn, Ph.D., Max-Planck-Institut, Köln, Germany
  Therapy Related
11:00 Cellular Therapy in Cardiology
Bernd Fleischmann, University of Bonn, Bonn, Germany
11:30 The Use of Genetically Modified Stem Cells in Gene Therapy
Evan Y. Snyder, M.D., Ph.D., Harvard University, Boston, Massachusetts, USA
12:00 Adjournment