Cambridge, Massachusetts, USA ~ 19-21  June 2002

Preliminary Program

| Educational Objectives | Preliminary Program |


Upon completion of this workshop, participants should be able to::
1.  Define the method of focused ultrasound thermal therapy;
2.  Compare various thermal ablation methods;
3.  Explain the thermal sensitivity of MR parameters;
4.  Apply the thermal sensitivity of MRI parameters for controlling energy deposition;
5.  Evaluate the clinical potential of MRI-guided thermal ablations;
6.  Demonstrate the advantages of focused ultrasound therapy over other thermal ablation methods;
7.  Describe the indications for MRI-guided thermal ablations;
8.  Identify problems associated with the lack of excised tissue samples in assessing therapy results.


Thursday, 20 June 2002
08:00 - 08:30 Welcome
SESSION I:   Basic Principles of Focused Ultrasound Surgery
08:30 - 10:00
Generation and Propagation of Ultrasound
Chris J. Diederich, Ph.D., Thermal Therapy Research Group, Radiation Oncology Department, University of California San Francisco, CA USA
Thermal Effects of Focused Ultrasound
Nathan McDannold, Ph.D., Department of Radiology, Harvard Medical School, Brigham & Women's Hospital, Boston, MA USA
Use of Cavitation for Therapy
J. Brian Fowlkes, Ph.D., Department of Radiology, University of Michigan, Ann Arbor, MI, USA
Ultrasound Phased Arrays
Shuki Vitek, InSightec-TxSonics, Inc., Haifa, Israel
10:00 - 10:30 Break
SESSION II:   Ultrasound Engineering and Systems and Bio-Effects
10:30 - 12:00
(5 presentations - Contributed Papers)
Two Dimensional  Array Design for Tissue Ablation for Treatment of Benign Prosthetic Hyperplasia, K. Saleh and Smith
Interstitial and catheter-based ultrasound applicators for conformal thermal therapy under MRI-guidance, C.J. Diederich, W.H. Nau, A.B. Ross, P.D. Tyreus, K. Butts, B. Daniel, D. Bouley, H. Gill, G. Sommer, UCSF Comprehensive Cancer Center & Stanford University Medical Center
New Piezocomposite Transducers for Therapeutic Ultrasound, G. Fleury, et al.
Translating the SURLAS to the Radiotherapy Clinic: Final Applicator Design, P. Novak, et al.
Effects of Short-Pulsed Focused Ultrasound ont eh Brain Vasculature in the Presense of an US Contrast Agent: Study on Rabbit In Vivo, N. Vykhodsteva, et al.
12:00 - 14:00 Break
SESSION III:  Image Guidance and Monitoring
14:00 - 16:00
Ultrasound Guidance and Monitoring
Emad S. Ebbini, Ph.D., Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA
MRI Temperature Monitoring Principles
Robert Mulkern, Ph.D., Department of Radiology, Harvard Medical School, Brigham & Women's Hospital, Boston, MA USA
Detection of Tissue Damage
Michael J. Bronskill, Ph.D., F.C.C.P.M., Sunnybrook & Women's College Health Sciences Center, University of Toronto, Toronto, Canada
MR-Elastography for Thermal Therapy Monitoring
Joel Felmlee, Ph.D., MRI Research Laboratory, Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN, USA
MRI Monitoring of Focused Ultrasound Surgery of implanted tumors
John D. Hazle, PhD, Department of Diagnostic Radiology, U. T. MD Anderson Cancer Center, Houston, TX, USA
16:00 - 16:30 Break
SESSION IV:  MRI Guidance and Monitoring
16:30 - 17:30
(4 Presentations)
MR Imaging-Guided Focused Ultrasound Surgery of Breast Cancer: Correlation of Dynamic Contrast-Enhanced MRI with Histopathalogic Findings, A. Khiat, et al.
Targeting Tool for Focused Ultrasound (FUS) Occlusion Using T1 Relaxation and Proton Resonant Frequency (PRF) Shift Parameters, Acquired with a Sliding Window (SW)-Dual Echo Spoiled Sequence, J. Ong, et al.
Paramagnetic Liposomes as Thermosensitive Probes for MRI-Guided Thermal Treatment: Feasibility Studies in Various Animal Models, S. Fossheim, et al.
The Feasibility of Using a Paramagnetic Blood Pool Contrast Agent (MS-325) for Magnetic Resonance Imaging-Guided Noninvasive Ultrasound Surgery, K. Lahti, et al.
18:30 - 21:00 Sponsored Dinner
Friday, 21 June 2002
SESSION V:   Clinical Applications of Focused Ultrasound Surgery -- Non-MRI vs. MRI
08:30 - 10:00
Narendra T. Sanghvi, Ph.D., Focus Surgery Inc., Indianapolis, IN USA
David Gianfelice, M.D., Radiology Department, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada
Gail ter Haar, Ph.D., Joint Physics Department, The Institute of Cancer Research, Royal Marsden Hospital, Surrey, England, UK
Uterine Fibroid
Claire Tempany, Ph.D., Department of Radiology, Brigham & Women's Hospital, Boston, MA USA
10:00 - 10:30 Break
SESSION VI:  Clinical Studies of MRI-Guided Focused Ultrasound Surgery
10:30 - 12:30
Uterine Fibroids
Waldyslaw Gedroyc, M.D., St. Mary's Hospital, London, England, UK
Uterine Fibroids
Jaron Rabinovici, M.D., Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel
Breast Cancer
Peter Huber, M.D., Deutsches Krebsforschungszentrum, Klinsche Koegerationseinheit, Strahlentherapeutische Onkologie, Heidelberg, Germany
Breast Cancer
Prof. Joerg Oestmann, Humboldt University, Charite Hospital, Berlin, Germany
Histology Observation after Focused Ultrasound Surgery in Breast Cancer
Sharon Thomsen, M.D., Biomedical Engineering Program, University of Texas, Austin, TX USA
Histology Observation after Focused Ultrasound Surgery in Uterine Fibroids
Bradley J. Quade, M.D., Ph.D., Department of Pathology, Brigham & Women's Hospital, Boston, MA USA
12:30 - 14:00 Lunch
SESSION VII:  Future Applications of MRI-Guided Focused Ultrasound Surgery
14:00 - 15:30
Brain Treatments
Kullervo Hynynen, Ph.D., Department of Radiology, Brigham & Women's Hospital, Boston, MA USA
Chrit T. Moonen, Ph.D., Université Victor Segalen Bordeaux 2, Bordeaux, France
Use of Ultrasound Contrast Agents
Evan C. Unger, M.D., Department of Radiology, University of Arizona Health Science Center, Tucson, AZ USA
Vascular Occlusions
Shahram Vaezy, Ph.D., Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA USA
15:30 - 16:00 Closing ceremony