ISMRM23 - Contrast Agents

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Contrast Agents

Weekday Course

ORGANIZERS: Henrik Odéen, Kei Yamada

Monday, 05 June 2023

718A

16:00 - 18:00

Moderators: Ji Eun Park & Jeffrey Weinreb

Skill Level: Basic to Intermediate

Session Number: M-07

CME and CE Credit

Session Number: M-07

Overview
This course will cover the basics of contrast agents, from the chemical structure and composition of agents currently used in the clinic, to pros and cons of pulse sequences commonly used for contrast enhanced imaging, which contrast agents are commonly used in various clinical applications, to new novel contrast agents currently under investigation.

Target Audience
This course is designed for scientists and clinicians who are interested in clinical and research applications of contrast enhanced MRI both in the clinic and in the research stage.

Educational Objectives
As a result of attending this course, participants should be able to:
- Recall the chemical composition of the most widely used contrast agents;
- Identify common clinical applications of contrast-enhanced imaging and which pulse sequence(s) is commonly used and why; and
- Identify new novel agents currently investigated and how they can improve contrast- enhanced imaging in the future.

16:00		Molecular Mechanisms of MRI Contrast View Presentation Video Eric Gale Keywords: Contrast mechanisms: Relaxometry This talk will discuss the molecular mechanisms that underpin paramagnetic nuclear magnetic relaxation, and how these principles can be applied to more potent MRI contrast agents and biochemically specific probes for molecular MR imaging. An understanding of T1 and T2 relaxation, and how these properties relate to MRI contrast, is assumed.
16:30		Techniques - commonly used pulse sequence for contrast enhanced MRI View Presentation Video Yae Won Park Keywords: Neuro: Brain, Contrast mechanisms: Perfusion, Education Committee: Clinical MRI Commonly used pulse sequences for contrast-enhanced MRI in brain tumors will be discussed in this lecture. Knowledge of underlying mechanism of contrast-enhanced MRI enhance our ability in diagnosis of brain tumors.
17:00		Applications - what contrast agent to use and when View Presentation Video Masahiro Tanabe Keywords: Contrast mechanisms: Contrast agents, Body: Liver The major classes of contrast agents currently used for magnetic resonance (MR) imaging of the liver include extracellular agents, hepatobiliary agents, and reticuloendothelial agents. This course will identify common clinical applications of contrast-enhanced imaging of the liver and what contrast agent is commonly used and when. We discuss properties of contrast agents, as well as their advantages and disadvantages, and present the recent research advances for improving this promising imaging method. Knowledge of these specific mechanisms, and typical and atypical enhancement pattern is important not only for accurate imaging-based diagnoses but also for understanding the pathogenesis of hepatic mass lesions.
17:30		Contrast agents of the future View Presentation Video Célia Bonnet Keywords: Contrast mechanisms: Contrast agents, Contrast mechanisms: Molecular imaging, Contrast mechanisms: Relaxometry This educational session will focus on the use of small metal complexes as MRI contrast agents, and more particularly on responsive contrast agents. T₁, as well as ParaCEST, Parashift and non-proton (¹⁹F) contrast agents will be presented. Among all the physiological parameters that can be detected using such complexes, a particular emphasis will be put on enzymatically-activated, and zinc responsive contrast agents. Indeed, these two biomarkers are misregulated during pathological processes such as cancers, or neurodegenerative diseases for example. Monitoring their changes should allow, in principle, early diagnosis as they appear prior to the morphological changes they trigger.