Cheng Zhang¹, Yujiao Zhao¹, Cong You¹, Zhiwei Shen², and Wen Shen^1
1Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ²Philips healthcare, Beijing, China

As transvaginal delivery may led to bony and soft birth canal injury, this study aimed to explore the possible relationship between the pelvic bones injury and the pelvic floor support muscles injury. In this study, we found that the pubic injury with significant clinical symptom may suggest the occurrence of pubococcygeus muscle injury with hidden symptoms. With the increased severity of the pubic bone injury, the higher the rate and severity of pubococcygeus muscle injury could be detected, which could be used to guide the clinical evaluation of abnormalities and corresponding rehabilitation treatment in time.

xueyan jiang^1
1Anhui Provincial Cancer Hospital, Hefei, Anhui, hefei, China

In conclusion, a combination of ADC values and TA based on three MRI sequences was developed to provide a noninvasive method for preoperatively predicting the expression levels of Ki-67 and p53 in EC. To some extent, this noninvasive imaging marker can compensate for the limitation of endometrium curettage biopsy and adverse impact of tumor heterogeneity, and it provide an objective imaging basis for clinical and accurate individualized treatment.

Lanhui Qin¹, Jin-ting Que¹, Xin-shu Li¹, Wei-hui Xu¹, Sheng-lian Wen¹, Huiting Zhang², Fang Wu¹, and Jin-yuan Liao^1
1First Affiliated Hospital of Guangxi Medical University, Nanning, China, ²MR Scientific Marketing, Siemens Healthcare Ltd, Nanning, China

This study explored the feasibility of whole tumor diffusion kurtosis imaging (DKI) histogram analysis (HA) to assess concurrent chemoradiotherapy (CCRT) combined with Endostar for locally advanced cervical cancer (LACC) before and during treatment. In terms of predicting efficacy, DKI whole tumor HA showed higher sensitivity and specificity, and higher the area under the ROC curve in the CCRT plus Endostar than in the CCRT group. During the treatment of LACC using  Endostar, compared with the mean value of ADC, MD, MK and tumor diameter, DKI whole tumor HA showed excellent potential in monitoring treatment response and predicting early efficacy.

Xiaoyan Yang¹, Min Liu¹, Jing An², Thomas Benkert³, Huaping Dai¹, and Chen Wang^1
1China-Japan friendship hospital, Beijing, China, ²Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³Siemens Healthcare GmbH, Erlangen, Germany

This study investigated the feasibility of ultrashort echo time (UTE)-MRI to evaluate the radiologic findings of idiopathic pulmonary fibrosis, using high resolution CT (HRCT) as the reference standard. UTE-MRI is inferior to HRCT in identifying the details of lung parenchyma. The results suggest that UTE-MRI is equivalent to HRCT. In addition, inter-method agreement between UTE-MRI and HRCT were equal to inter- and intra-observer agreement for UTE-MRI for evaluating disease findings. Moreover, performance analyses demonstrated that UTE-MRI efficacy for detecting radiologic findings of pulmonary fibrosis, such as reticulation, traction bronchiectasis, and honeycombing were similar to that of HRCT.

Tao Lu¹, Yishuang Wang¹, and Shaoyu Wang^2
1Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People’s Hospital, Chengdu, China, ²MR Scientific Marketing, Siemens Healthineers, shanghai, China

This study investigated the diagnostic value of monoexponential, biexponential, and diffusion kurtosis MR imaging (MRI) in differentiating placenta accreta spectrum (PAS) disorders. The results showed that D mean and D max differed significantly among all the studied parameters for differentiating PAS disorders. A combined use of these two parameters yielded an AUC of 0.93 with sensitivity, specificity, and accuracy of 83.08%, 88.89%, and 83.70%, respectively. This suggested the quantitative evaluation of PAS disorders with different DWI models and PAS disorders can be differentiated effectively with the combined use of the different DWI parameters.

Mengtian Sun¹, Jingliang Cheng¹, Cuiping Ren¹, Jie Ma², and Liangjie Lin^3
1MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Philips Healthcare, Beijing, China

This study aims to investigate the value of whole-body DWIBS and mDIXON Quant imaging in monitoring the response to induction therapy of multiple myeloma focal lesions (FLs). Significant differences in the number of multiple myeloma focal lesions (FLs), the maximum diameter of FLs, ADC, FF, T2* values, ADC change rate, FF change rate and T2* change rate were observed between the deep remission group and the non-deep remission group. The FF change rate was the best discriminator of the deep remission.

Chao Wu¹, Peng Zhang¹, Chen Zhang², Yajun Li¹, and Haoran Sun^1
1Tianjin Medical University General Hospital, Tianjin, China, ²Siemens Healthcare, Beijing, China

The purpose of this study was to observe the swallowing process of hiatal hernia patients using real-time magnetic resonance imaging (MRI) and to evaluate the transport of contrast agents through the gastroesophageal junction and the induction of sliding hernia during Valsalva. Results showed that hiatal hernia was detected in all patients enrolled in the study. Therefore, real-time MRI imaging of sliding hiatal hernia has great potential for clinical application.

Qiu Bi¹, Qing Li¹, Yunzhu Wu², Shaoyu Wang², and Kunhua Wu^1
1the First People’s Hospital of Yunnan Province, Kunming, China, ²Siemens Healthineers, Shanghai, China

Magnetization transfer imaging (MTI) is sensitive to reveal macromolecules in tumor tissues. This study aimed to evaluate the correlation between magnetization transfer ratio (MTR) and histological features and risk stratification in endometrial carcinoma and cervical cancer. We found that MTR value could differentiate endometrial carcinoma from cervical cancer and facilitate preoperative risk stratification of endometrial carcinoma. It could provide a preoperative basis for cancerous histologic origin and risk assessment in uterus.

Chumin Huang¹, Zisan Zeng¹, and Huiting Zhang^2
1Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ²MR Scientific Marketing, Siemens Healthnieers, Hubei, China

The purpose of this study is to explore the feasibility of magnetic resonance imaging (MRI) 3D multi-echo-Dixon (ME-Dixon) and T2-corrected multi-echo single-voxel (HISTO) spectroscopy sequences to evaluate osteoporosis by comparison with quantitative computed tomography (QCT). The results show that the proton density fat fraction (PDFF) values of bone marrow measured by these two MRI methods have high and significantly negative correlation with bone mineral density (BMD) values measured by QCT at lumbar.

Wei-Min Hung¹, Ching-Wei Gu¹, Guo-Shu Huang¹, Charng-Chyi Shieh², Chia-Wei Li², Yen-Chang Chen², and Yi-Chih Hsu^1
1Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ²GE Healthcare, Taipei, Taiwan

This study focused on the accuracy of standardized uptake value (SUV) reconstructed using the corrected MR attenuation correction (MRAC) images with time-of-flight (TOF) information by PET in patients with metallic implants. We compared the SUV of both paraspinal and psoas muscles in patients with and without implant for TOF reconstructed PET images. In the result, there was no significance in the SUV measurements obtained from MRAC between no-implant and with-implant patients. And therefore, our study demonstrated that SUVs measured from TOF PET/MR of lumbar implant indicated good reliability and robust of MRAC.

Fang Wang¹, Dawei Ding², Weiqiang Dou³, Dmytro Pylypenko³, Qing Wang¹, and Dexin Yu^1
1Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, ²Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, ³GE Healthcare, Beijing, China

This study aims to investigate the feasibility of multi-parametric MRI in distinguishing endometrioma from other ovarian cystic lesions. A total of 50 patients with clinically suspected endometriosis were recruited in the study. Quantitative MRI, including T1, T2 mapping, T2* mapping and CEST, was used. A positive correlation was found between R2* and iron levels in fluid of endometrioma. The AUC of R2*, T1, T2 and MTR_asym were 0.941, 0.996, 0.980 and 0.806, respectively. Therefore, multi-parametric quantitative MRI can be considered an effective method in differentiating endometriomas from various ovarian cystic lesions.

Shifeng Tian¹, Ailian Liu^1,2, Changjun Ma¹, Lihua Chen¹, Nan Wang¹, Liangjie Lin³, Jiazheng Wang³, and Zhigang Wu^3
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Dalian Medical Imaging artificial intelligence engineering technology research center, Dalian, China, ³Philips Healthcare, Beijing, China

Endometrial polyps (EP) is a common disease of uterine body, with a prevalence rate of about 8~25% in female population. Its clinical symptoms can be like those of endometrial carcinoma (EC), with vaginal bleeding, but there are obvious differences in prognosis and treatment between them. The purpose of this study is to investigate the value of differential diagnosis for staging Ia EC and EP by using amide proton transfer (APT) and diffusion kurtosis imaging (DKI). It shows that APT and DKI can be used to distinguish between stage Ia EC and EP. effectively and quantitatively

Feifei Zang¹, Xinyi Liu¹, Dandan Fan¹, Cancan He¹, Zhijun Zhang², and Chunming Xie^2
1Southeast University, Nanjing, China, ²Southeast University Affiliated ZhongDa Hospital, Nanjing, China

Brain networks of Alzheimer’s disease (AD) represent the fluctuating functional connectivity with time. Using the sliding-window method, this study identified two different functional connectivity states at the large-scale network level in AD spectrum. The AD patients took more time in the tense-connected state II than the non-AD populations. Moreover, lipid metabolism-related factors affected the dynamic network connectivity across the AD spectrum populations. These results provide insights into the neural biological underpinnings of the dynamic networks reorganization for AD pathophysiology.

Ning Zhang¹, Kun Peng², Ailian Xiao², and Jinxia Guo^3
1Shanxi Medical University, Taiyuan, China, ²The Sixth Hospital of Shanxi Medical University, Taiyuan, China, ³GE Healthcare, Beijing, China

Obstructive sleep apnea hypopnea syndrome (OSAHS) can lead to cognitive dysfunction, and in severe cases, it may develop into dementia. Early, timely and accurate diagnosis is of great significance to delay the progression of the disease, improve the quality of life and improve the prognosis. Diffusion kurtosis imaging (DKI) based on non-Gaussian model to characterize the diffusion of water is regarded as a more sensitive technology to explore the microstructural tissue changes in compare with diffusion tensor imaging (DTI). In this study, the mean kurtosis (MK) from DKI is used to assess the possible abnormality of brain regions in white and gray matter in moderate and severe OSAHS patients. And the correlation between MK values and cognitive function changes was also analyzed. The MK was found to be associated with changes in 9 brain regions including right postcentral gyrus gray matter, parietal lobe gray matter, insular gray matter, left precentral gyrus white matter, frontal lobe white matter and bilateral cingulate gyrus, left occipital lobe gray matter, and well correlated with attention, delayed recall, which can be helpful for understanding of the potential mechanism for neurocognitive function impairment and doing the evaluation.

shanshan Shen¹, shuqian Zhang¹, yingmin Chen¹, and Lizhi Xie^2
1Hebei General Hospital, Shijiazhuang, China, ²GE Healthcare, Shijiazhuang, China

Trigeminal neuralgia (TN) characterized by recurring paroxysmal pain, severely affects the quality of life (QoL) of patients. In this study, we compared brain network frame remodeling in TN patients before and after percutaneous micro-balloon compression (PMC) operation with healthy controls (HCs) using graph theory analysis. Both TN pre-treatment patients (Pre) and HCs exhibited small-world network organization. Pre TN patients had abnormal global network construction, Pos recovered, but in local network index increased. Graph theory analysis could be a useful method to detect instant change after operation.

Qiangqiang Liu^1,2, Shuheng Zhang³, Jiwen Xu^1,4, Jiachen Zhu³, Yiwen Shen⁵, Changquan Wang², Wenzhe Chen², Jun Yang³, and Jianmin Yuan^6
1Department of Neurosurgery, Clinical Neuroscience Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China, ³United Imaging Healthcare, Shanghai, China, ⁴Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Department of Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁶Central Research Institute, United Imaging Healthcare, Shanghai, China

With 3D T2 FLAIR imaging, trigeminal nerve is clearly demonstrated with CSF nulled, while low SNR and low spatial resolution is always the limitation. In this study, we introduced a 0.75mm isotropic resolution whole brain 3D T2 FLAIR imaging in 5min 40sec based on a novel deep learning framework, and evaluated on a small patient cohort who underwent MR-guided robot-assist percutaneous balloon compression (PBC). To our knowledge, this is the first clinical report of MR-guided robot-assist PBC surgery based on DL accelerated 3D scan.