Masaru Shiotani¹, Yoshiaki Morita¹, Yoshito Ichiba², Yasuhiro Nagai¹, Wataru Ueki¹, Tatsuhiro Yamamoto¹, Yasutoshi Ohta¹, Keizo Murakawa¹, and Tetsuya Fukuda^1
1Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, ²MR Research & CollaborationDpt. Diagnostic Imaging Division, Siemens Healthcare K.K., Shinagawa-ku, Tokyo, Japan

The peak ratio of 3.5ppm to water in 1H-MRS of myocardium showed the higher values in Fabry disease and the association with native T1 values and regional function. 1H-MRS has a potential as disease-specific imaging biomarker for direct quantification of myocardial sphingolipid accumulation of Fabry disease.

Shengliang Liu¹, Jianxiu Lian², Haixia Li², Guokun Wang¹, Yunling Li¹, Yanming Zhao¹, Bing Xu¹, and Bo Yu^1
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, ²Philips Healthcare, Beijing, China

Hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) share similar features, such as thickened left ventricular (LV) wall and reduced compliance, which make it difficult to distinguish HCM from HHD clinically. In this retrospective study, patients with HCM and HHD were enrolled to evaluate the feasibility of radiomic analysis to differentiate between these two diseases. For all calculated texture analysis (TA) features, AUCs of nine parameters had the values above 0.65, Logarithm_glszm_ZoneEntropy reached the best performance than other parameters (AUC: 0.790, sensitivity: 71.4 %, specificity: 81.8 %, P < 0.01).

Dongyue Si¹, Rui Guo², Bowei Liu¹, Daniel A. Herzka³, and Haiyan Ding^1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, ³National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Myocardial T₁ and T₂ mapping enable quantitative detection of various cardiac diseases. Here we propose a fast 3D free-breathing simultaneous T₁ and T₂ mapping sequence, which acquires four volumes for joint estimation of T₁ and T₂. A very small flip angle is used for efficient sampling of the equilibrium longitudinal magnetization. Whole-heart T₁ and T₂ maps were acquired with high resolution of 1.5×1.5×4mm³ within 5 min in normal human subjects with image quality comparable to conventional 2D methods.

Shengliang Liu¹, Jianxiu Lian², Yunling Li¹, Guokun Wang¹, Haixia Li², Xueying Wang¹, Yanming Zhao¹, Bing Xu¹, and Bo Yu^1
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, ²Philips Healthcare, Beijing, China

To evaluate the value of left ventricular radial strain (LVRS) and left ventricular circumferential strain (LVCS) in discriminating between hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) by using cardiac magnetic resonance feature tracking (CMR-FT). HCM patients presented higher values of LVRS and LVCS when compared with HHD patients. And both LVRS and LVCS correlated obviously with left ventricular ejection fraction (LVEF) in HCM patients. Furthermore, the combination of strain with LGE can significantly improve the diagnostic ability for differentiation HCM from HHD (AUC: 0.86; sensitivity: 86.9 %; specificity: 76.3 %).

Gang Yin¹, Zhixiang Dong¹, Shihua Zhao¹, Xiuyu Chen¹, Kai Yang¹, Ke Jiang², and Zhigang Wu^2
1Fuwai Hospital, Beijing, China, ²Philips Healthcare, Beijing, China

This study is to examine the feasibility of T1 rho and native T1 mapping for endogenous detection of diffuse and focal myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Results showed that absolute T1 rho increased progressively and significantly from healthy controls to HCM without LGE and then to HCM with LGE, whereas T1 native increased significantly only from healthy controls to HCM with LGE. Besides, both T1 rho and native T1 had moderate correlation with LGE ratio in severe segments.

Shi Rui¹, Gao Yue¹, Shen Li-ting¹, and Yang Zhi-gang^1
1West China hospital of Sichuan University, Chengdu, China

The majority of heart failure (HF) in hypertrophic cardiomyopathy (HCM) manifests as a phenotype with preserved left ventricular (LV) ejection fraction, however, the exact contribution of left atrial (LA) phasic function to HF with preserved ejection fraction (HFpEF) in HCM remains unresolved. We designed the study to define the association between LA function and HFpEF in HCM patients using cardiac MRI feature tracking.  The result revealed that LA phasic function was severely impaired in HCM patients with HFpEF, whereas LV function was not further impaired compared with non-HF patients.

Shengliang Liu¹, Jianxiu Lian², Ke Jiang², Guokun Wang¹, Yunling Li¹, Xueying Wang¹, Yanming Zhao¹, Bing Xu¹, and Bo Yu^1
1Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China, ²Philips Healthcare, Beijing, China

Acute myocardial infarction is the result of occlusion of cardiac arteries, which leads to myocardial ischemic injury and even necrosis. Diffusion weighted imaging (DWI) and T2* mapping were performed to investigate the correlation between apparent diffusion coefficient (ADC) and T2* values in ST-segment elevation myocardial infarction (STEMI) patients here. ADC values of infarct regions were higher than those in border regions, remote regions in patients with STEMI, and also higher when compared with control group. Conversely, T2* values showed opposite trend. What’s more, there was a negative correlation between T2* and ADC values (r = 0.-734; P < .001).

Jing Liu¹, Jing Li², Huaxia Pu², Wenzhang He¹, Xue Li¹, Xiaoyue Zhou³, Nanwei Tong², and Liqing Peng^1
1Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, ³MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

This study evaluated right ventricular (RV) functional changes using cardiac magnetic resonance (CMR) tissue tracking and the association of these changes with fat distributions in obese adults with no clinical signs or comorbidities. The results showed that CMR tissue tracking can detect subclinical RV dysfunction with preserved RV ejection fraction in obese adults. Central obesity, represented by android fat, trunk fat, and the android/gynoid fat mass ratio, had a deleterious effect on RV subclinical dysfunction, whereas peripheral obesity (gynoid fat) might have had a protective effect. These findings could contribute to more precise obesity management in clinical practice.

Jing Liu¹, Jing Li², Huaxia Pu¹, Wenzhang He¹, Xue Li¹, Xiaoyue Zhou³, Nanwei Tong², and Liqing Peng^1
1Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China, ³MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

This study evaluated left ventricular (LV) diastolic functional changes and left atrial (LA) functional indices using cardiac magnetic resonance (CMR) tissue tracking and volume-time curve in obese adults with no clinical signs or comorbidities. The association of LV diastolic function with fat distributions was also assessed. The results showed that CMR detected subclinical LV diastolic dysfunction, impaired LA reservoir and conduit function with preserved LV ejection fractions in adults with obesity. LV diastolic function was associated with LA reservoir and conduit function. Visceral fat was deleterious for LV diastolic function, while peripheral obesity might have had a protective effect.

Jianing Cui¹, Tao Li¹, Yanan Zhao¹, and Xiuzheng Yue^2
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, ²Philips Healthcare, Beijing, China, Beijing, China

Many ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI) are still exposed to a consequence known as left ventricular (LV) remodeling. Most studies have reported that reverse LV remodeling is associated with improved patient outcomes. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study assesses the predictive role of LV volume, LV function and infarct characteristics by CMR on reverse LV remodeling after STEMI. Our data showed that peak CK-MB, extent of MVO volume of LV were independent predictors of reverse LV remodeling.

Juan Zou¹, Cheng Li¹, Ruoyou Wu¹, Zhenzhen Xue¹, Xin Liu¹, Hairong Zheng¹, and Shanshan Wang^1
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, shenzhen city, China

Fast data acquisition and high-quality image reconstruction are vital for dynamic MRI, which can capture both anatomical and temporal information. High-resolution acquisition approaches in k-space and super-resolution approaches after reconstruction have been frequently reported. However, these methods may get details lost at high acceleration factors. To address this issue, we propose a multi-scale detail preserving reconstruction method for dynamic MR images. The residuals of multi-scale intermediate images in the iterative procedure are explored and the temporal and spatial dependencies between frames are considered. Promising results are achieved by the proposed method at the high acceleration factor of 11.

Pei-Hsuan Kuo¹, Cheng-Chia Lee^2,3,4, Huai-Che Yang^2,3, Hsiu-Mei Wu^3,5, and Chia-Feng Lu^1
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²Department of Neurosurgery, Neurological Institute, Taipei Veteran General Hospital, Taipei, Taiwan, ³School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ⁴Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ⁵Department of Radiology, Taipei Veteran General Hospital, Taipei, Taiwan

Cavernous malformation (CM) is one of the common cerebral vascular diseases. Hemorrhage is a common and dangerous symptom of CMs, and re-hemorrhage may still occur in 30% of patients after the treatment of Gamma Knife radiosurgery (GKRS). Till now, the prediction of occurrences of future re-hemorrhage in CMs are still less explored. In this study, we used statistical analyses to observe longitudinal changes in MRI radiomic features before re-hemorrhage after GKRS. We aimed to identify the reliable image biomarkers using the quantitative and non-invasive MRI technique as early predictors to guide the clinical management for CM patients.