Functional MRS: Current Challenges & Cutting-Edge Methods
Member-Initiated Symposium
Wednesday, 11 May 2022
ICC Capital Suite 14-16
14:30 - 16:30
Session Number: MIS-08
Georg Oeltzschner, and Anouk Schrantee.
Overview
Functional MRS is rapidly emerging as a technique of great interest due to its potential to measure quantitative neurochemical changes in response to brain activation. As such, fMRS allows us to address fundamental questions related to normal brain function as well as metabolic alterations in neurodegenerative and neuropsychiatric diseases. While an increasing number of researchers actively engage in fMRS, there is little consensus regarding best practices in experimental design, data acquisition, data analysis, and interpretation. Furthermore, acquisition and analysis methods are not very accessible to those new in the field.
We therefore recently initiated a fMRS interest group, gathering methods developers and application-oriented MRS users alike. This group intends to assess the status quo of best practices, and pool resources to approach methodological harmonization. The proposed symposium will 1) initiate a joint fMRS platform; 2) highlight cutting-edge methodological progress; 3) improve access to the field
The session will be divided into 3 parts. In the first part, we will have oral presentations, an expert panel discussion (including ""ask the expert"" Q&A submitted by attendees) focusing on experimental design and underlying metabolic processes. The second part will focus on cutting-edge analysis and quantification methods with live code demonstrations. Finally, the third part will allow junior researchers to showcase their fMRS science in a power-pitch format.
Target Audience
MRS and fMRI researchers (clinicians, neuroscientists, physicists), particularly junior/trainee researchers and those new to the field of (f)MRS
Educational Objectives
As a result of attending this course, participants should be able to:
Highlight the potential of fMRS to understand changes in functional metabolism during brain activity|Showcase cutting-edge fMRS data analysis and modeling methods|Stimulate continued discussion on current challenges in fMRS acquisition, analysis, and interpretation|Improve accessibility of fMRS methods for those new to the field
14:30
The Impact & Implication of ¹H fMRS to the MRS Field
Video Unavailable
Jeffrey Stanley
Wayne State University
14:50
Deuterium Labeling Enables Noninvasive 3D Proton MR Imaging of Glucose & Neurotransmitter Metabolism in Humans
Video Unavailable
Petr Bednarik
Medical University of Vienna
15:10
In Silico Models to Bridge the Gap Between Synaptic Activity & Human in Vivo Quantification of Neurotransmitter Dynamics
Video Unavailable
Caroline Lea-Carnall
The University of Manchester
15:30
Panel Discussion
Video Unavailable
Assaf Tal1, Nathalie Just2, Paul Mullins3, Charlotte Stagg4
Weizmann institute of science1, Danish Research Centre for Magnetic Resonance2, Bangor University3, Oxford University, United Kingdom4
15:50
Using all the Information: Fitting Functional MRS with a GLM
Video Unavailable
William Clarke
Oxford University
16:10
MP-PCA Denoising: A Boost for fMRS Spatio-Temporal Resolution?
The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
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