ISMRM22 - MRI of Cartilage

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

MRI of Cartilage

Weekend Course

ORGANIZERS: Xiaojuan Li, Edwin Oei

Saturday, 07 May 2022

ICC Capital Suite 10-11

08:00 - 12:00

Moderators:
Cartilage I: Miika Nieminen
Cartilage II: Jamie MacKay
Cartilage III: Feliks Kogan
Cartilage IV: Valentina Mazzoli

Skill Level: Intermediate to Advanced

Session Number: WE-02

Session Number: WE-02

Overview
Degenerative diseases such as osteoarthritis are becoming more and more prevalent and presenting in ever-younger patients in both the developed and less-developed parts of the world. Novel, less-invasive treatments are being developed, which require accurate pre-surgical diagnoses and non-invasive methods to follow patients after interventions. MRI has long been the modality of choice for both qualitative and quantitative imaging, but application of advanced techniques to clinical practice has been challenging. This course will present the latest concepts and techniques for imaging articular cartilage from the perspective of radiologists, surgeons, physicists, engineers, and basic researchers.

Target Audience
Radiologists, physicists, basic scientists, and trainees.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain how MRI, including quantitative and qualitative, can be applied to the diagnosis, treatment planning, and assessment of diseases and conditions affecting articular cartilage in advanced clinical practice;
- Describe how surgeons view and use MRI in their practice to manage and follow patients and what current treatment options exist;
- Apply information learned from experts how to translate innovations and advances in MRI for cartilage to their own practices; and
- Describe how studies in animals and ex vivo tissue translate from bench to bedside.

	Cartilage I
08:00		Cartilage Anatomy & Structure: MRI Correlation View the Presentation Matthew Koff Correlates to morphologic and quantitative MRI assessments of articular cartilage will be presented
08:25		The Role of MRI of Cartilage in Improving Clinical Management in Orthopedics: A Surgeon's Perspective View the Presentation Daniel Saris Cell based surgical repair of cartilage has progressed to a reliable therapeutical option. advanced imaging modalities with automated segmentation and disease focused presentation of relevant findings that correlate to patient's disease and monitor progress of healing would represent tremendous patient centered progress
	Cartilage II
08:50		Morphologic MR Imaging of Cartilage in Trauma & OA View the Presentation Akshay Chaudhari The lecture will present various different imaging methodologies that have been used for morphological and qualitative assessment of articular cartilage. We will discuss the benefits and challenges of these imaging techniques separately for clinical use-cases in assessing cartilage trauma as well as in research-focused studies evaluating cartilage degeneration in osteoarthritis.
09:15		Quantitative MRI of Cartilage: Relaxometry View the Presentation Victor Casula Quantitative relaxometry extends MRI beyond anatomical imaging and provides information on the physical structure, composition, and functional state of cartilage. Quantitative MRI techniques reflect the interaction of water with cartilage macromolecules and allow detection of early biological changes in cartilage. This part of the educational course is an overview of the most established techniques for quantitative relaxometry of cartilage, namely T2, T2* and T1ρ mapping and dGEMRIC. We will review their relationship with physiological properties of cartilage and give a description of their potential value as diagnostic biomarkers followed by a discussion of the limitations and challenges towards clinical applications.
09:40		Break & Meet the Teachers
	Cartilage III
10:00		Quantitative MRI of Cartilage: Diffusion, gagCEST & Sodium View the Presentation Vladimir Juras Osteoarthritis (OA) is a disease affecting the entire joint, including articular cartilage, subchondral bone, synovial tissues and menisci. Early OA stages in cartilage are manifested by a loss of glycosaminoglycans and disruption of collagen matrix. Quantitative MRI techniques provide an useful tool for detection of the structural changes. Here, the diffusion weighted MRI, gagCEST and sodium MRI are discussed, including each method pitfalls and advantages, as well as the overview of (clinical) applications.
10:25		MRI of Cartilage: Ex Vivo & Animal Models with Clinical Correlation Video Unavailable Eveliina Lammentausta
	Cartilage IV
10:50		Translation of Quantitative MR of Cartilage from Research to Clinical Care View the Presentation Thomas Link In order to institute quantitative cartilage MRI in clinical practice a number of requirements need to be met. First of all, it is essential to define the exact clinical indications for quantitative imaging and how they would impact patient care. Second, image acquisition and analysis need to be standardized and meet clearly defined claims including reproducibility. Finally, sequences need to be approved by regulatory agencies and be available as a product from manufacturers. In this presentation we will discuss these different steps.
11:15		7T MRI for Cartilage Video Unavailable Neal Bangerter