Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

2022 Joint Annual Meeting ISMRM-ESMRMB and 31st ISMRT Annual Meeting

Weekend Course

MR Physics & Engineering I: Dances with Spins

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MR Physics & Engineering I: Dances with Spins
Weekend Course
ORGANIZERS: Mark Ladd, Rita Schmidt, Philipp Ehses, Sune Jespersen
Saturday, 07 May 2022
N11 (Breakout A)
08:00 -  12:00
Moderators: 
History & Basic Principles of MRI: Rita Nunes
Theory of Relaxation : José Marques
Bloch Equations: Jennifer McNab
Extended Phase Graphs: Matthias Weigel
Skill Level: Basic to Intermediate
Session Number: WE-07
 

Session Number: WE-07

Overview
This course covers the basic physics underlying magnetic resonance imaging. This includes a quantum mechanical description of spins in static and time-dependent magnetic fields, a simplified description of the semiclassical theory of relaxation, Bloch equations including some generalizations, and basic RF excitation.

It is suggested to bring pen and paper to participate.

Target Audience
Physicists and engineers interested in learning/refreshing the foundations of MRI.

Educational Objectives
As a result of attending this course, participants should be able to:
- Recall the quantum mechanical formulation of nuclear magnetic resonance;
- Explain the physical mechanisms responsible for T1, T2 and T2* relaxation (including predicting the effects of e.g. temperature, B-field);
- Derive the Bloch equations;
- Manipulate the Bloch equations and predict magnetization in simple cases;
- Reproduce extensions to the Bloch equations, such as Bloch-Torrey, McConnell; and
- Analyze echo pathways employing the extended phase graph formalism.
 

    History & Basic Principles of MRI
  08:00   Basic Principles of MRI: A Historical Perspective
TBD
08:30   Nuclear Spins: From Quantum Mechanics to Classical View

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Gonzalo Alvarez
In this talk, I would introduce the basic physics underlying nuclear magnetic resonance. I will present the quantum mechanical description vis-à-vis the classical description of non-interacting spins in static (B0) and time-dependent fields (B1). The spin polarization and its corresponding thermodynamic equilibrium will be introduced based on the density matrix representation. The spin state evolution is dictated by the Liouville–von Neumann equation that gives the laws on how the spin polarization and its coherence evolve as a function of time. This quantum equation of motion arrives at the Bloch equation.
    Theory of Relaxation
09:00 Semiclassical Theory of Relaxation

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Valerij Kiselev
The goal of this lecture is to explain the mechanisms of relaxation caused by the thermal motion of molecules. The focus is on emergence and the role of the correlation functions of random magnetic field. Properties of these functions help understanding the dependence of longitudinal and transverse relaxations on the rate of molecular motion. The difference in these dependencies is the key for explaining several phenomena practically important for NMR and MRI. This lecture relies on the basic notions of analysis, quantum mechanics, statistical physics and Fourier transformation. 
  09:30   Interactive Session
 
  10:00   Break & Meet the Teachers
 
    Bloch Equations
10:30   Basic Bloch Equations

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Jana Hutter

The Bloch equations form the basis of MR contrast mechanisms. They provide a classical description of the evolution of the magnetization during any MRI experiment and thus allow to understand how the magnetization evolves under different conditions and influences.  This lecture will introduce the Bloch equations and give an overview of different sets of conditions affecting MR experiments. The main types of relaxation are introduced and examples shown.

 

11:00   Extensions to the Bloch Equations - chemical exchange

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Moritz Zaiss
The extension of the Bloch equations regarding chemical exchange are shown and analyzed. Analytical solutions provide sound insight in the Bloch-McConnell equation system that underlie every exchange-weighted contrast, be it CEST, T1ρ or T2, as well as semisolid magnetization transfer. In this lecture we show that for all experiment affecting the water magnetization, a single eigenvalue solution is able to describe all these experiments. This knowledge forms the basis for interpretation of the outcomes of different exchange-weighted contrasts as well as quantification of exchange.
    Extended Phase Graphs
11:30 Extended Phase Graphs

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Shaihan Malik
This talk will aim to introduce the concept of using phase graphs both as an intuitive analytic tool, and as a method of numerical simulation.
  12:00   Interactive Session

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