Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

2022 Joint Annual Meeting ISMRM-ESMRMB and 31st ISMRT Annual Meeting

Weekend Course

Putting Muscle into MRI of Muscle

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Putting Muscle into MRI of Muscle
Weekend Course
ORGANIZERS: Iman Khodarahmi
Sunday, 08 May 2022
ICC Capital Suite 7 & 12
07:45 -  11:45
Moderators: 
MRI Muscle I: Pierre Carlier
MRI Muscle II: Dimitrios Karampinos
MRI Muscle III: Mark Schweitzer
MRI Muscle IV: Christopher Burke
Skill Level: Intermediate to Advanced
Session Number: WE-18
 

Session Number: WE-18

Overview
Junior Fellow Observer: Stefan Ruschke

This course will review advanced imaging techniques for muscle with an emphasis on high level clinical translation. Topics to be covered include neuromuscular disease and quantitative and qualitative assessment of muscle in health and disease (including neuromuscular disease, metabolic disorders, motor neuron disease and trauma). Principles and applications of quantitative imaging and spectroscopy for muscle will be reviewed and discussed in the context of their application in clinical practice. Exercise physiology and dynamic imaging of muscle, the anatomy and imaging of the myotendinous unit, MR neurography in the context of neuromuscular disease, and whole-body MRI for body composition will also be reviewed and discussed. The speakers in this session will illustrate technical, clinical, and imaging perspectives that will present an integrated approach to muscle imaging.

Target Audience
Radiologists, physicists, engineers, and trainees.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify basic types of neuromuscular diseases and the clinical application of MRI in the management of neuromuscular, metabolic, and motor neuron disease;
- Summarize quantitative imaging techniques and the basic principles of spectroscopy (proton and multinuclear) in the probing muscle tissue;
- Explain the anatomy and physiology of the myotendinous unit in the context of MRI in health and disease; and
- Discuss current and future status of whole-body MRI for body composition, including acquisition techniques and body composition markers.

    MRI Muscle I
07:45   MRI Applications in Neuromuscular Disorders

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Benjamin Howe
08:10   MRI Neurography in Neuromuscular Disease

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Shivani Ahlawat
    MRI Muscle II
08:35   Quantitative Muscle Imaging

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Hermien Kan
Quantitative MR imaging is usually slower compared to MR conventional imaging, but has the advantage of being more objective, precise and sensitive to detect changes. In this talk I will highlight a number of quantitative MRI techniques that are commonly used in skeletal muscle, along with their accuracy, sensitivity, reproducibility, and relation to a biological property. Quantitative MR of muscles makes use of range of techniques and as pathology is rarely limited to a single feature, there is a strong added value in combining different MR measurements, where assessments are co-localized based on pathology.
09:00   Proton & Multinuclear Spectroscopy of Muscle

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Linda Heskamp
This lecture introduces the basic principles of MR Spectroscopy at a basic level suitable for clinicians with a specific focus on skeletal muscle. Metabolites detectable with 1H MRS, 31P MRS, 13C MRS and 23NA MRS will be discussed together with the software and hardware requirements.  
  09:25   Break & Meet the Teachers
 
    MRI Muscle III
09:50   MRI of Body Composition

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Danoob Dalili
10:15 Morphologic Imaging of the Myotendinous Unit

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Jung-Ah Choi
In this presentation, the author will familiarize the audience with anatomy and structure of muscle with emphasis on morphologic MR imaging of normal muscle, as well as MRI of pathologic conditions of muscle, including trauma and non-traumatic lesions, including inflammatory myositis, infectious myositis, rhabdomyolysis, atrophy with fatty infiltrations due to congenital or denervation atrophy. After this talk, the audience should be able to diagnose different pathologies of muscle on morphologic MRI. 
    MRI Muscle IV
10:40 Exercise Physiology & Dynamic MRI

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Benjamin Marty
Dynamic magnetic resonance spectroscopy (MRS) and imaging (MRI) techniques are perfectly suited to investigate the physiological adaptation of the skeletal muscle during exercise. The consumption and resynthesis of adenosine triphosphate (ATP), which is the principal high-energy phosphate molecule that enables muscle contraction can be precisely followed using dynamic 31P MRS.  Oxygen delivery and extraction, which limit the rate of ATP resynthesis during aerobic exercise can be estimated from the Fick law, using perfusion MRI coupled with susceptometry and/or deoxy-myoglobin 1H MRS. All these valuable data can be recorded at once during the same exercise bout using multinuclear interleaved sequences.
    MRI Muscle I
11:05   Case Review with Discussion

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Darryl Sneag

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.