Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

2022 Joint Annual Meeting ISMRM-ESMRMB and 31st ISMRT Annual Meeting

Weekend Course

Facilitating Technique Translation

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Facilitating Technique Translation
Weekend Course
ORGANIZERS: Brian Hargreaves, Khin Tha, Andrew Scott
Sunday, 08 May 2022
N11 (Breakout A)
12:30 -  16:30
Moderators: 
Quantitative Imaging Examples: Jeanette Schulz-Menger
Rapid Imaging & Reconstruction Examples: Tobias Schaeffter
Addressing the Challenges: Stefan Skare
Skill Level: Intermediate
Session Number: WE-26
 

Session Number: WE-26

Overview
Clinical MRI uses only a limited set of the many many novel methods that are proposed, developed and evaluated in humans. Some techniques are used in almost every part of the body and every protocol, while others may be common for one area of anatomy but not used elsewhere. Finally, many methods either take years to become clinically accepted, or never reach this stage. This session explores some of the common requirements for clinical translation of new techniques. Examples of techniques that are widely used across imaging protocols are given, with rationale for such use. More advanced techniques that are only used in certain areas are described. Finally, promising techniques that are still not common in products are described, along with the challenges that remain. The session closes by exploring the steps that vendors must follow in the final stages of productization and the factors that determine whether these methods are then used in routine everyday clinical practice.

Target Audience
Ph.D. scientists who are developing new methods with the goal of widespread clinical utilization, and M.D.s who are interested in new techniques that may not be currently used in their area of specialization

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify common MRI sequences that are used routinely in many protocols or body parts and explain the reasons for their success;
- List desirable attributes for clinically usable sequences;
- Identify steps required to move an initial proof-of-concept of a technique or method towards clinical utility;
- Describe methods that are used in some applications, but not others, with rationale;
- Identify some methods that are promising for translation, but are not yet products; and
- List steps that a vendor goes through in final stages of productization.


 


    Widely Used Sequence Examples
12:30   Everyday Sequences: How & Why They Are in the Protocol

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C. C. Tchoyoson Lim
Clinical MRI protocols comprise individual MR pulse sequences put together to help radiologists answer a clinical question. Which sequences to select necessitates trade-offs between highest resolution spatial or function biomarkers and safety, reliability, speed. Standard Brain MRI protocols include T1, T2, flow, diffusion sequences: there is a high bar for replacing or adding to current protocols. The need for reproducibility & QIBA best practice to enhance the value of MRI will be discussed.
12:50 DWI & DTI: Where, Why & How It Is & Is Not Used

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Kei Yamada
Diffusion-weighted imaging (DWI)and diffusion-tensor imaging (DTI) has become one of the essential research/clinical tools in analyzing the brain in both normal and pathological states. In this presentation, I will first cover the brief history of DWI, and then explain how this tool has become an essential part of our daily practice. 
    Quantitative Imaging Examples
13:10   DENSE: A Technique in Translation

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Xiaoying Cai
Myocardial strain imaging is an important approach for quantifying cardiac function. Cine DENSE is a dedicated MR technique for strain imaging. By encoding tissue displacement into the phase of the imaging signal, cine DENSE allow rapid and comprehensive quantification of myocardial mechanics. This talk gives an overview of about cine DENSE imaging from data acquisition to reproducibility and its translation. 
13:30 Relaxometry: Where, Why & How It Is & Is Not Used

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Nikola Stikov
The promise of relaxometry is making MR measurements that reproduce across sites. The qMRI community has not delivered on this promise, and clinicians are losing patience. The only way forward is through standardization, data sharing, and opening up the black boxes that generate the numbers. 

More at: http://qmrlab.org/relaxometry
  13:50   Break & Meet the Teachers
 
    Rapid Imaging & Reconstruction Examples
14:10   Parallel Imaging: How & Why It Moved So Quickly to Product

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Rita Nunes
The aim of this talk is to introduce the basic concepts of Parallel Imaging and to discuss what made it such a successful technique. Parallel imaging took advantage of the availability of multichannel coil arrays to accelerate exams. It has had a major impact in MRI, quickly becoming available on standard scanners and being used in every day routine clinical practice.
14:30 Spirals: History, Opportunities, & What It Will Take to Get It into Routine Clinical MRI

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James Pipe
Spiral MRI was invented by Ann and Cho in 1986, and was greatly enabled by the Stanford MRSL in the early 1990's.  This method continues to evolve, and beyond just being a "fast" MRI method, it has many unique favorable properties, including low gradient moments, very low minimum TE, incoherent underdamping artifacts, and the capacity for high SNR efficiency.  Despite all of this, Spiral MRI is not widely used clinically. This talk will outline some of the remaining obstacles to clinical adoption, with high confidence that they can be overcome.
14:50 CS & AI: Will They Tread the Same Path to Translation?

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R. Marc Lebel
This course covers aspects related to translation and commercialization of new MR techniques. We will identify and explain factors paving the perilous road to commercial success with a specific focus on AI applications. The aim is to provide insight into the common reasons why novel applications falter and to provide design principles that improve chances of successful translation from bench to bedside.
    Addressing the Challenges
15:10 What Do I Need to Get My New Technique into a Product?

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Maggie Fung
Just invented the next breakthrough in MRI technology? That’s only part of the equation. This presentation will cover what it takes to develop and productize new MRI technology, starting from identifying the unmet needs, innovation, down-selection and clinical validation, to commercialization and regulatory aspects. We will walk through some successful examples and summarize the key ingredients to a successful product.
15:30   From Product to Routine Clinical Practice

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Christopher Filippi
This talk discusses implementation science in MRI, which promotes the uptake of research and other evidence-based imaging studies into routine, clinical practice.   Barriers to adaptation of emerging imaging technology include variability across scanners and sites such as magnetic field strengths, protocols, MR vendor and model types.  Linearity, bias, and precision of measurements are needed for consistent, patient-specific management according to Radiology Society of North America’s Quantitative Imaging Biomarker Alliance (QIBA). (1-3) Quantitative imaging markers are needed for precision health, but determination of “ground truth” and lack of a clear road map limit impact currently.
  15:50   Live demos: Systems and Components

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