ISMRM22 - MR Physics & Engineering IV: Field of Dreams

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

MR Physics & Engineering IV: Field of Dreams

Weekend Course

ORGANIZERS: Rita Schmidt, Mark Ladd, Natalia Petridou, Özlem Ipek

Sunday, 08 May 2022

ICC Capital Hall 2

12:30 - 16:30

Moderators:
Super-High Field (SHF) Magnets: Ergin Atalar
Acquisition Techniques for SHF: Dennis Klomp
Beyond 20T: Maxim Zaitsev

Skill Level: Intermediate to Advanced

Session Number: WE-28

Session Number: WE-28

Overview
This educational course will introduce the questions of next-generation high field NMR and MRI, introducing the challenges and the opportunities of super-high field (SHF) MRI. Attendees will be provided with an overview of existing magnet systems beyond 12T as well as aspects for human and molecular spectroscopy and imaging. The overview will include the potential to increase the sensitivity and specificity and cover the possible superconducting materials that are key to SHF MRI. The attendees will be taught about the application and safety questions in SHF MRI.

Target Audience
Curious scientists wanting to discover what we can reach next.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the energy storage required for super-high field (SHF) MRI, candidate superconducting materials, and the challenges to building such magnets;
- Evaluate the limitations and potential for achieving SHF MRI;
- Describe the pulse sequences required to acquire a signal in SHF MRI;
- Explain the sensitivity and specificity that can be reached; and
- Describe promising applications and safety for SHF MRI.

	Super-High Field (SHF) Magnets
12:30		Why Go to Super-High Fields (SHF) & What Are the Challenges? View the Presentation Mark Bird The Iseult magnet has reached the limit of human MRI with traditional NbTi superconductor. Higher field will require Nb3Sn that has been used for preclinical MRI and large scale fusion magnets. Meeting all constraints of a clinical system at 14 T or higher presents new challenges. REBCO has enabled high-resolution NMR to jump from 23.5 T to 28.2 T and shows potential for NMR at 35 T and human MRI at 20 T. Using resistive materials, NMR is being done at up to 35.2 T dc with ~1 ppm resolution while 55 T is possible for short pulses.
12:55		Superconducting Materials for Super-High Field NMR and MRI View the Presentation Hideaki Maeda This lecture discusses superconducting materials and related technological challenges, the potential for super-high field NMR and prospects for super-high field MRI. It firstly describes the NMR magnet's development and potentials. Secondly, the prospect and challenges in creating a super-high field MRI magnet will be presented.
	Acquisition Techniques for SHF
13:20		Acquisition Techniques for 1H View the Presentation Lucio Frydman
13:45		X-Nuclei Acquisition View the Presentation Jeanine Prompers Metabolic perturbations are a key driving factor in many diseases and measuring metabolic responses is therefore promising to provide early treatment efficacy markers. MRS measurements of X-nuclei, such as ³¹P, ¹³C and ²H, yield unique information on in vivo metabolism. However, X-nuclei have a low intrinsic sensitivity and commonly used surface coils for X-nuclei have a low penetration depth. Ultra/super-high field greatly enhances the sensitivity for X-nuclei and, together with innovative coil designs, boosts the potential of X-nuclei metabolic imaging. In this educational, we highlight major applications, and discuss recent methodological advancements and challenges of X-nuclei acquisition at ultra/super-high field.
14:10		Break & Meet the Teachers
	Beyond 20T
14:35		GHz NMR View the Presentation Dinu Iuga The UK High Field Solid State NMR National Research Facility provides access to 20 T (850 MHz) and 23 T (1 GHz) spectrometers and probes capable of spinning samples at the Magic Angle at very high spinning frequencies (100 kHz). Under very fast MAS, the ¹H spin echo life time becomes considerably longer opening up the possibility to investigate ¹H-¹H proximities or to detect other atoms in vicinity to ¹H. Enhanced sensitivity and enhanced resolution provided by the high magnetic fields allows for structural insights not possible at lower magnetic fields, like understanding cell wall architecture.
15:00		Beyond 40T: Pulsed NMR Video Unavailable Anna Orlova
	Potential & Challenges for SHF MRI
15:25		Promising In-Vivo Applications for 1H & X-Nuclei View the Presentation Samuel Grant
15:50		SHF Safety: What Do We Know So Far? View the Presentation Andrea Grant MR safety above 7T includes both subject safety and practical considerations for researchers. In this talk I will discuss what we know about exposure to static fields above 9.4T, including human exposure at 10.5T and pre-clinical work at 16.4T. I will also discuss 6 other areas of note for safety considerations, including validation of RF coil models, acoustic noise measurements, B0 projectile risks, implants at 7T and above, occupational exposure, and practical considerations.