View Presentation Video

Jinli Meng^1,2,3, Yingxue Gao², Hailong Li², Lingxiao Cao², Wanlin He¹, Li Feng¹, Yongyue Guo¹, Xin Hu¹, Hengyan Li¹, Chenghui Zhang⁴, Yunhong Wu⁴, and Xiaoqi Huang^2,3
1Department of Radiology, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital. C.T.), Chengdu, Sichuan, China, ²Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, ³Psychoradiology Research Unit of the Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, China, ⁴Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital. C.T.), Chengdu, Sichuan, China

Keywords: Endocrine, Diabetes

We performed a seed-based rsFC study to explore the hippocampus and the amygdala FC patterns in plateau Tibetan patients with T2DM. We found that, compared to plateau Tibetan HC, T2DM showed both increased rsFC between the right hippocampus and left DLPFC and left SFG, and between the left amygdala and right OFC as well as right DLPFC.Moreover, these rsFC abnormalities were significantly correlated with age, RBC and changes of visuospatial memory function in plateau Tibetan patients with T2DM. These findings of altered FC may provide important insights into the neural basis of diabetes-related cognitive decline in plateau Tibetan.

View Presentation Video

Michele Pascale¹, Vivek Muthurangu¹, Javier Montalt Tordera¹, and Jennifer Steeden^1
1University College London, London, United Kingdom

Keywords: Digestive, Body

We present a novel approach to synthesise high-resolution isotropic 3D abdominal MR images, from anisotropic 3D images in an unpaired fashion. Using a modified CycleGAN architecture with a novel gradient mapping loss, we leverage disjoint patches from the high-resolution (in-plane) data of an anisotropic volume to enforce the network generator to increase the resolution of the low-resolution (through-plane) slices. This will enable accelerated whole-abdomen scanning with high-resolution isotropic images within short breath-hold times.

View Presentation Video

Alexandra Webster¹, Agata Dukaczewska², Martina Mogl², Tom Meyer¹, Bernd Hamm¹, Ingolf Sack¹, and Stephan Marticorena Garcia^1
1Department of Radiology, Charité - Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Department of Surgery, Charité - Universitaetsmedizin Berlin, Germany, Berlin, Germany

Keywords: Endocrine, Elastography, Adrenal Gland, Multifrequency magnetic resonance elastography, Adrenal stiffness, Shear wave speed, Viscoelasticity

The ability to distinguish a benign from a malignant adrenal mass based on magnetic resonance imaging relaxation times is severely limited. For the first time at all, this study adrenal gland stiffness was investigated by using magnetic resonance elastography in healthy controls and participants with adrenal adenoma and malignoma. In healthy controls MRE was highly reproducible. Adrenal adenoma and malignoma are stiffer than healthy controls and both could be distinguished by an excellent diagnostic performance (AUC 0.8–1.0). MRE is promising non-invasive biomarker for clinically difficult differentiation of a malignancy and could prevent surgical overtreatment in the future.

View Presentation Video

Hidemitsu Sotozono¹, Akihiko Kanki¹, Yoshihiko Fukukura¹, Kiyoka Maeba¹, Akira Yamamoto¹, and Tsutomu Tamada^1
1Department of Radiology, Kawasaki Medical School, Kurashiki, Japan

Keywords: Pancreas, Pancreas

We sought to clarify the value of quantitative MRI for evaluating pancreatic fibrosis. Longer T1 relaxation time and lower D within the pancreas parenchyma were significantly related to pancreatic fibrosis score based on histopathological evaluation. T1 relaxation time and D may be sensitive indicators of fibrosis within the pancreas parenchyma.

View Presentation Video

Lixia Wang¹, Lu Liang², Jiyang Zhang², Yang Zhou², Yang Yu², Chen Zhang³, Tao Jiang², Qi Yang², Christie Jeon⁴, Srinivas Gaddam⁵, Stephen J Pandol⁵, Yibin Xie¹, and Debiao Li^1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Radiologic department, Beijing Chaoyang Hospital, Captial Medical University, Beijing, China, ³MR Scientific Marketing, Siemens Healthcare, Beijing, China, ⁴Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁵Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Keywords: Pancreas, Quantitative Imaging, T1 value, T2 value, ADC value

The pancreas plays an important role in nutrition and metabolism of the whole body. Changes of pancreatic morphology and function are related to many diseases.  Multiparametric MR provides quantitative information about pancreatic morphology and function. In this work, we measured the normal range of T1, T2, and ADC values for different gender and age groups, and found significant differences between age groups. Gender difference was only found in T2. There are negative correlations between T2/ADC and age, and positive correlation between T1 and age.

View Presentation Video

Akihiko Kanki¹, Yoshihiko Fukukura¹, Hidemitsu Sotozono¹, Kiyoka Maeba¹, Atsushi Higaki¹, Akira Yamamoto¹, and Tsutomu Tamada^1
1radiology, Kawasaki Medical School, kurashiki, Japan

Keywords: Pancreas, Pancreas

We evaluated relationships of age and gender with shifted apparent diffusion coefficient (sADC), proton density fat fraction (PDFF), T1 relaxation time, and pancreas size using 3-T MRI. sADC increased and anterior-posterior diameter decreased with age, while T1 relaxation time and PDFF showed no correlations with age. These results would offer beneficial information regarding pancreatic imaging.

View Presentation Video

Antonella Meloni¹, Laura Pistoia¹, Vincenzo Positano¹, Nicolò Schicchi², Gennaro Restaino³, Luigi Barbuto⁴, Ada Riva⁵, Giuseppe Peritore⁶, Letizia Tedesco⁷, Angela Ermini⁸, Domenico Visceglie⁹, Costanza Bosi¹⁰, Paola Maria Grazia Sanna¹¹, and Filippo Cademartiri^1
1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, ³Gemelli Molise SpA, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ⁴Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, Napoli, Italy, ⁵Ospedale “SS. Annunziata” ASL Taranto, Taranto, Italy, ⁶"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, ⁷Presidio Ospedaliero Locri - A.S.P di Reggio Calabria, Locri (RC), Italy, ⁸Ospedale S. Maria Annunziata, Bagno a Ripoli (FI), Italy, ⁹Ospedale “Di Venere”, Bari, Italy, ¹⁰Ospedale “G. Da Saliceto”, Piacenza, Italy, ¹¹Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy

Keywords: Pancreas, Tissue Characterization

On the basis of the type of gene mutation, three groups of patients with thalassemia major were identified: homozygotes β+, compound heterozygotes β+/β° and homozygotes β°. β0β0 patients were more likely to have pancreatic iron overload than both β+β+ patients and β0β+patients and had a double risk of alterations of glucose metabolism compared to β+β+ patients. Our findings support the knowledge of the different genotypic groups in the clinical management of β-TM patients.

View Presentation Video

Siya Shi¹, Liqin Wang¹, Jiaxin Yuan¹, Xuefang Hu¹, Xingyan Xie¹, Tingting Wen¹, Jinhui Yu¹, and Yanji Luo^1
1The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

Keywords: Pancreas, Surgery, Magnetic resonance elastographies, Pancreatectomy, Pancreatic fistula

This prospective study enrolled the patients who underwent both preoperative tomoelastography and pancreaticoenteric anastomosis. Eighty-two patients were included (median age: 59.5 years, 40 men, 18 patients with POPF). Main pancreatic duct diameter (MPDD) (P=0.012), c (P<0.001) and φ (P=0.001) were relevant factors for POPF. The area under the curve (AUC) of c, φ and MPDD for predicting POPF was 0.880, 0.816 and 0.747. Fibrosis was the relevant factor of POPF (P=0.001). There was positive correlation between fibrosis and stiffness (r=0.681, P<0.001). Tomoelastography is a novel and robust multi-frequency MRE technique that can facilitate the prediction of POPF.

View Presentation Video

Masahiro Tanabe¹, Mayumi Higashi², Keiko Hideura², Kenichiro Ihara², Thomas Benkert³, Hiroshi Imai⁴, Masatoshi Yamane⁵, Takahiro Yamaguchi⁶, Atsuo Inoue², and Katsuyoshi Ito^2
1Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube, Japan, ²Radiology, Yamaguchi University Graduate School of Medicine, Ube, Japan, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁴MR Research and Collaboration, Siemens Healthcare K.K., Tokyo, Japan, ⁵Department of Radiological Technology, Yamaguchi University Hospital, Ube, Japan, ⁶Yamaguchi University Hospital, Ube, Japan

Keywords: Pancreas, Diffusion/other diffusion imaging techniques

This study evaluated the image quality of modified reduced field-of-view (FOV) DWI using 2D spatially-selective RF pulses with tilted excitation plane (tilted r-DWI) for pancreatic ductal adenocarcinomas (PDACs) compared with conventional full-FOV DWI (f-DWI). Two radiologists evaluated the MR image quality, and SNR, CNR, and ADC values of the pancreatic lesions were quantitatively assessed. Image quality scores and CNR of tilted r-DWI were significantly higher than that of f-DWI. The ADC values of PDACs showed no significant deference between them. Tilted r-DWI provides better image quality with less artifacts and higher pancreatic lesion conspicuity than f-DWI.

View Presentation Video

Kang Wang¹, Matthew J. Middione¹, Andreas Markus Loening¹, Daniel Ennis¹, and Ryan Lennex Brunsing^1
1Radiology, Stanford University, Palo Alto, CA, United States

Keywords: Pancreas, Diffusion/other diffusion imaging techniques, Diffusion Weighted Imaging, M1-nulled, ADC

Multi-shot DWI reduces image distortion while increasing SNR. More recently, motion-compensated diffusion encoding has been shown to reduce artifacts and improve ADC consistency in single-shot DWI. Motion-compensated multi-shot pancreatic DWI may also mitigate artifacts arising from shot-to-shot incoherence. Herein, we conducted a pilot study of multi-shot DWI of the pancreas with and without motion-compensated diffusion encoding. Image quality and artifacts were scored by expert radiologists. ADC values of different pancreatic anatomical segments were computed.  Multi-shot DWI with motion-compensated gradient encoding increased homogeneity of signal intensity and ADC values across the pancreas. 

View Presentation Video

Anne-Sophie van Schelt^1,2, Kim Johanna Beek^1,3, Nienke Petronella Maria Wassenaar¹, Eric M. Schrauben¹, Jurgen H. Runge¹, Aart J. Nederveen¹, and Jaap Stoker^1,2,3
1Radiology and Nuclear Medicine, AmsterdamUMC, location AMC, Amsterdam, Netherlands, ²Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands, ³Endocrinology, Metabolism, Amsterdam Gastroenterology, Amsterdam, Netherlands

Keywords: Digestive, Quantitative Imaging

Crohn’s Disease (CD) is a chronic inflammatory bowel disease. Mesentery of afflicted bowel loops often is involved. MR-Elastography allows assessment of its underlying mechanical properties and gives more insight in the role of the mesentery . Feasibility was first shown in 15 healthy volunteers. Seven patients with active CD (aCD) scheduled for surgical intervention underwent pre-operative MR-Elastography acquisition and histopathological analysis. Seven age- and sex matched volunteers were also scanned. Significantly higher shear wave speed, shear stiffness and phase angle were found in aCD patients, possibly related to increased fibrotic tissue in or inflammation of the mesentery.

View Presentation Video

Alexander R Guimaraes¹, Joyce Kim², Kaveh Sharzehi³, Gregory Cote³, Lisa Wang¹, Bryan Foster¹, and Cory Wyatt^1
1Radiology, OHSU, Portland, OR, United States, ²OHSU, Portland, OR, United States, ³Medicine, OHSU, Portland, OR, United States

Keywords: Pancreas, Data Analysis

Chronic pancreatitis is a chronic fibro-inflammatory syndrome of the pancreas that often leads to exocrine pancreatic insufficiency EPI. Secretin MRCP provides an approach for quantifying function.   Present interpretation of sMRCP lends itself to variability in interpretation .  Further, previous approaches for quantitative assessment of sMRCP have been difficult to reproduce. We have developed a mathematical model for quantifying various features of dynamic sMRCP and have shown in a retrospective cohort, significant differences in one feature that correlates to delay of pancreatic production of fluid, to separate and correlate to ePFT and FE. 9

View Presentation Video

Hiroshi Hamano¹, Masami Yoneyama¹, Masahiro Enzaki², Minako Azuma³, Nobuyuki Toyonari⁴, and Takashi Namiki^1
1Philips Japan, Tokyo, Japan, ²Division of Radiology, Miyazaki University Hospital, Miyazaki, Japan, ³Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan, ⁴Department of Radiology, Kumamoto Chuo Hospital, Kumamoto, Japan

Keywords: Pancreas, Pancreas, MRCP

3D TSE RT is commonly used to MRCP imaging. But the image qualities of them are unstable especially in patients with irregular respiratory motion and tachypnea. A T2-prepared pulse is often used to emphasize long T2 component such as CSF, bile, and pancreatic duct. A 3D VANE has been applied in abdominal imaging as a useful free-breathing technique. We attempted to combine bTFE based on 3D VANE with magnetization T2prep pulses (3D REMASTAR) for MRCP instead of, otherwise in addition to 3D TSE RT. We have demonstrated the feasibility of 3D REMASTAR MRCP particularly in subject with unstable respiratory motion.

View Presentation Video

Nabeelah Jinnah¹, Olivier Mougin¹, Penny Gowland¹, Caroline Hoad¹, Lauren Gascoyne¹, Christopher Clarke², and Gordon Moran^1
1University of Nottingham, Nottingham, United Kingdom, ²Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

Keywords: Digestive, CEST & MT

Z-spectrum imaging was performed on bowel wall from Crohn's disease patients, to determine it's potential as a method of determining the fibrotic component of scarred bowel wall. Results show that there is a difference between the MT amplitude and linewidth of healthy compared with strictured bowel wall. Future work will involve optimising a protocol to use as a imaging biomarker of the fibrosis within bowel wall in Crohn's disease.

Lan Zhang¹, Xin Li¹, Peng Sun², and Fan Yang^1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Techonology, Wuhan, China, ²Philips Healthcare, Beijing, China, Beijing, China

Keywords: Digestive, Cancer

We conducted this prospective study to determine whether APTw imaging is precise in evaluating treatment response of LARC after NCRT, by comparing the accuracy of evaluation using APTw imaging to that of T2-weighted imaging and DWI, which is value for the selection of organ preservation candidates.

Wenjuan Liu^1
1Beijing Aviation General Hospital, Beijing, China

Keywords: Pelvis, Cancer

We applied natural language processing (NLP) to the extraction of relevant information from MRI reports of rectal cancer written in Chinese. We used 358 MRI reports written between 2015 and 2021 to develop a rule-based NLP model to extract 11 key image features. The accuracy, precision, recall, and F1 score of our NLP model for correct extraction of values from reports were 93.82%, 95.63%, 87.06%, and 91.15% for pre-2015 reports, and 92.55%, 98.53%, 94.15%, and 96.29% for post-2021 reports. Our NLP system with rule-based pattern matching realized the rapid and accurate structured processing of rectal cancer MRI reports. 

View Presentation Video

Atsuo Inoue¹, Masahiro Tanabe¹, Kenichiro Ihara¹, Keiko Hideura¹, Thomas Benkert², Hiroshi Imai³, Masatoshi Yamane⁴, Takahiro Yamaguchi⁴, Mayumi Higashi¹, and Katsuyoshi Ito^1
1Department of Radiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, ²MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ³MR Research and Collaboration, Siemens Healthcare K.K., Tokyo, Japan, ⁴Department of Radiological Technology, Yamaguchi University Hospital, Yamaguchi, Japan

Keywords: Pelvis, Diffusion/other diffusion imaging techniques, Rectum

This study evaluated the image quality of reduced FOV DWI using 2D spatially-selective RF pulses with tilted excitation plane (tilted r-DWI) for rectal cancer compared with full-FOV DWI (f-DWI) using readout segmented echo-planar imaging (RS-EPI). Two radiologists evaluated the MR images, and SNR, CNR, and ADC values of the rectal lesions were quantitatively evaluated. All image quality scores and CNR were significantly higher in tilted r-DWI than in f-DWI with RS-EPI. SNR and ADC values showed no significant deference between them. Tilted r-DWI provides better image quality with less artifacts and higher rectal lesion conspicuity than f-DWI with RS-EPI.

View Presentation Video

Deshuo Dong¹, Anliang Chen¹, Changjun Ma¹, Ailian Liu¹, and Qingwei Song^1
1radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

Keywords: Pelvis, fMRI

Mutant P53 promotes tumor cell proliferation, invasion, and resistance to chemotherapy. The purpose of this study was to evaluate the value of intravoxel incoherent motion (IVIM) imaging for prediction of P53 expression status in rectal cancer. The results indicate that D and f values for positive P53 status were significantly lower than those for negative P53 status, while D* was higher. The combination of D, D* and f improved diagnostic efficiency than single parameters. IVIM imaging allows non-invasive visualization and quantification of tissue composition for prediction of P53 status in rectal cancer.

Xiwei Li¹, Anliang Chen¹, Nan Wang¹, Jiazheng Wang², Liangjie Lin², and Ailian Liu^1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare,Beijing, Beijing, China

Keywords: Digestive, Cancer

Lymphatic vascular invasion（LVI）can help clinicians choose the best treatment strategy for patients. Pathological examination is the gold standard for the diagnosis of LVI in rectal cancer, but it is an invasive method. Multiparametric magnetic resonance imaging is valuable for the prediction of LVI in rectal cancer. In this study, we quantitatively evaluated the value of LVI in rectal cancer using T2 mapping and DWI sequences.

Wenguang Liu¹, Yigang Pei¹, Weiyin Vivian Liu², Xiao Wang¹, Yu Bai¹, Yijing Luo¹, Gaofeng Zhou¹, and Wenzheng Li^1
1Radiology, XiangYa Hospital, Central South University, Changsha, China, ²MR research, GE Healthcare, Beijing, China

Keywords: Cancer, Quantitative Imaging

To preoperative assessment of tumor and node staging for rectal cancer patients is very important. This study aimed to investigate the feasibility of predicting pathological TN staging with synthetic MRI quantitative relaxation maps for rectal cancer patients. A total of 123 patients were identified in this study. Our results showed that the T1 and T2 values from synthetic MRI can distinguish effectively between pT1-2 and pT3-4 group, pN- and pN+ group, which is vital to selection of therapy strategy for rectal cancer patients.