Jia Liu¹, Jianxing Qiu¹, Wei Li¹, Jiangkai He¹, Kai Zhao¹, and Jianxiu Lian^2
1Peking University First Hospital, Beijing, China, ²Philips Healthcare, Beijing, China

Keywords: Myocardium, Cardiovascular, Cardiac magnetic resonance,Feature tracking,Strain,Cardiac amyloidosis

Subjects were divided into light-chain amyloidosis (AL-CA), transthyretin-related amyloidosis (ATTR-CA) and control group.  CMR-FT technique was used to measure apical, middle and basal strain of left ventricle. Results showed ICC value was higher than 0.9 in all strain parameters, and meanwhile all strain parameters in AL-CA group and ATTR-CA group were lower than those in control group except for apical RS. However, there was no statistical difference between the AL-CA group's and ATTR-CA group. Strain evaluation could evaluate patients of CA, which may provide evidence for the treatment and diagnosis of CA.

View Presentation Video

Keyan Wang¹, Jie Zheng², Jing An³, and Jingliang Cheng^1
1MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Mallinckrodt Institute of Radiology, St. Louis, MO, United States, ³Siemens Healthineer, Shenzhen, China

Keywords: Cardiomyopathy, Myocardium

The study evaluated left ventricular (LV), right ventricular (RV), and left atrial (LA) myocardial strain and heart function derived from cine magnetic resonance (MR) imaging for chemotherapeutic efficacy and predicted their prognostic value in patients with light-chain (AL) amyloidosis. Our results demonstrated that these parameters may be noninvasive imaging markers allowing assessment of the chemotherapeutic effect and may offer independent prognostic information for all-cause mortality in patients with AL amyloidosis.

View Presentation Video

Jianing Cui¹, Tao Li¹, Xiuzheng Yue², and Chuncai Luo^1
1Radiology, the First Medical center, PLA General Hospital, Beijing, China, ²Philips Healthcare, Beijing, China

Keywords: Heart, MR Value, cardiac magnetic resonance-feature tracking

Early diagnosis of cardiac amyloidosis (CA) and accurate assessment of cardiac function is important for CA patients. LV strain and strain rate obtained by cardiac magnetic resonance-featured tracking (CMR-FT) have been developed as sensitive indicators of myocardial function. This study aimed to evaluate myocardial function in patients with CA by strain and strain rate to assess their prognostic value in patients with CA. Our data showed that strain rate could be used to assess the degree of cardiac impairment in CA and the difference with HCM providing prognostic information for all-cause mortality in CA patients.

View Presentation Video

El-Sayed H. Ibrahim¹, Antonio Sosa¹, Jadranka Stojanovska², Lindsay Puckett¹, Elizabeth Gore¹, and Carmen Bergom^3
1Medical College of Wisconsin, Milwaukee, WI, United States, ²New York University, New York, NY, United States, ³Washington University, St Louis, MO, United States

Keywords: Heart, Heart

Radiation therapy (RT) plays a key role in treating thoracic cancer, although the incidence of RT-induced cardiac complications could be as high as 33%. Nevertheless, characterization of baseline heart function, myocardial tissue characteristics and hemodynamic parameters in this patient population is not well elucidated, which was investigated in this study. The results revealed suboptimal cardiac function (both systolic and diastolic) and associations between different MRI cardiovascular parameters at baseline. Therefore, the condition of the cardiovascular system at baseline should be taken into consideration as a contributing factor in the development of RT-induced cardiotoxicity in thoracic cancer patients.

junqi liu¹, qianfeng luo¹, wanyin qi¹, zhengyuan xiao¹, xiaoyong zhang², xingyuan kou¹, and jing chen^1
1The Affiliated Hospital of Southwest Medical University, Luzhou, China, ²Clinical Science, Philips Healthcare, Chengdu, China, Chengdu, China

Keywords: Cardiomyopathy, Cardiomyopathy

This study investigated segmental strain to evaluate early anthracycline-induced cardiotoxicity on a 1.5T MR system in New Zealand rabbits models. The apical lateral wall and the anterior apical wall have a statistical difference corresponding to the pathological results in the second week. The ejection fraction showed statistical difference at the eighth week, while the global strain was not even statistically significant. The result showed that the peak segmental strain was earlier than the peak global strain and cardiac function, which may provide an effective and convenient monitoring method for chemotherapy patients.

View Presentation Video

El-Sayed H. Ibrahim¹ and John Charlson^1
1Medical College of Wisconsin, Milwaukee, WI, United States

Keywords: Heart, Cancer

Anthracycline chemotherapy is the mainstay of cancer treatment. While the most important late, potentially permanent, side effect of chemotherapy is cardiotoxicity, the short-term acute effects of chemotherapy on cardiac function are not well elucidated. In this study, we used advanced cardiac MRI to assess subclinical changes in cardiac function immediately post chemotherapy treatment. The results demonstrated that strain and strain rate are sensitive imaging parameters that allow for early detection of changes in systolic and diastolic myocardial contractility immediately post chemotherapy despite slight changes in global cardiac function and tissue characterization.

View Presentation Video

Huiming Dong¹, Ang Zhou¹, Natalie Au², Mehrdad Arjomandi², and Dimitrios Mitsouras^1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Divisions of Pulmonary, Critical Care, Allergy, and Sleep Medicine and Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, CA, United States

Keywords: Myocardium, Myocardium, Cardiopulmonary; Second-Hand Smoker

Prolonged exposure to secondhand tobacco smoke (SHS) is associated with abnormal pulmonary function and cardiovascular response. In this study, we examined cardiac function in SHS-exposed participants using cardiac MR (CMR) and displacement encoding with stimulated echoes (DENSE) to determine whether the cardiac function is affected by air trapping-a hallmark of heavy past SHS exposure. We found that SHS-exposed participants had lower myocardial radial strain than unexposed participants at both end-inspiration and end-expiration imaging. Neither stroke volume nor cardiac output exhibited the decrease seen in unexposed participants at end-inspiration, but radial strain was significantly lower compared to end-expiration in SHS-exposed participants.

View Presentation Video

Yunling Li¹, Kai Yang², Xiuyu Chen², Jianxiu Lian³, Yong Sun¹, and Shihua Zhao^2
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, HarBin, China, ²Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing, China, ³Beihang University, Beijing, China

Keywords: Heart, Cardiovascular, Heart failure

To investigate the relationship correlation of cardiac magnetic resonance (CMR) feature tracking (FT)-derived right ventricular (RV) global longitudinal strain (RV-GLS) and RV global circumferential strain (RV-GCS) with mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) to explore the diagnostic value of RV strain parameters in advanced left heart failure patients with pulmonary hypertension (PH). Study findings included as following: (a) CMR-FT RV-GLS and RV-GCS were independent risk factors for PH in patients with end-stage left heart disease, among all CMR imaging parameters; (b) Both RV-GCS (AUC = 0.868) and RV-GLS (AUC = 0.873) were valuable in predicting PH.

View Presentation Video

Jianxiu Lian¹, Shengliang Liu², Yunling Li², Guokun Wang², Xueying Wang², Ye Li², Xiaofang Xu¹, and Yanming Zhao^2
1Philips Healthcare, Beijing, China, ²The Second Affiliated Hospital of Harbin Medical University, Harbin, China

Keywords: Cardiomyopathy, Cardiomyopathy, hypertrophic obstructive cardiomyopathy, hypertrophic non-obstructive cardiomyopathy

Hypertrophic cardiomyopathy (HCM) can be divided into two types according to pressure gradient of left ventricular outflow tract, which means different prognosis and risk stratification. Feature tracking technology can be used to calculate strain value in three orientations and evaluate the ability of myocardial deformation. Our results showed that strain differences can be detected between HCM and control group. Segmental strain and torsion also showed significant differential value between hypertrophic obstructive cardiomyopathy (HOCM) and hypertrophic non-obstructive cardiomyopathy (HNOCM) group.Our study may provide evidence in differentiating HOCM and HNOCM for further treatment. 

Zilong Ren¹, Didi Wen², Jianxiu Lian³, Jiantao Liu³, Zhe Huang³, and Minwen Zheng^4
1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, ²Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, ³Philips Healthcare China, Xi'an, China, ⁴Xijing Hospital, Fourth Military Medical University, Xi'an, China

Keywords: Myocardium, Animals

To explore whether myocardial strain can predict functional changes for ischemia with non-obstructive coronary artery disease (INOCA) in animal models. Results showed pigs with INOCA had lower global circumferential strain (GCS) and global longitudinal strain (GLS) (mean GCSnormal = -20.2 ± 2.0 %, mean GCSINOCA = -16.6 ± 1.4 %, P = 0.009; mean GLSnormal = -19.6 ± 1.9 %, mean GLSINOCA = -14.5 ± 3.0 %, P = 0.027). Therefore, the results showed that the myocardial deformation decreased in pigs with INOCA, which could provide information for the therapy of INOCA patients.

Xiao Du¹, Jian Wang¹, Jian Yao¹, Ruopeng Wang¹, Mengyue Han¹, Tiantian Yang¹, YingCui Zhu¹, Chenglin Xu¹, Zheng Jing¹, Deyue Yan¹, Baijie Li¹, and Xiuzheng Yue^2
1Central Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Philips Healthcare, Beijing, China

Keywords: Heart, Cardiovascular, Cardiac magnetic resonance; Obstructive sleep apnea-hypopnea syndrome; Dilated cardiomyopathy

The obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with heart failure and dilated cardiomyopathy (DCM) patients all show left ventricular dilatation and systolic dysfunction as the main phenomenon. Still, there are very few reports on identifying the two diseases. Herein cardiac magnetic resonance (CMR) myocardial strain technology was used to evaluate the cardiac function and myocardial structure of the OSAHS and DCM patients. The results showed that the global peak circumferential and longitudinal strains and the left ventricular myocardial mass of the DCM group were lower than the OSAHS group. This research provides reference for the identification of these two diseases.

Ao Kan¹, JianKun Dai², Shuhao Li¹, MengYao Hu¹, and Lianggeng Gong^1
1The Second Affiliated Hospital of Nanchang University, Nanchang, China, ²GE Healthcare, Beijing, China

Keywords: Cardiomyopathy, Cardiomyopathy, Cardiac magnetic resonance

This study aiming at assessing the impact of malignant ventricular arrhythmia (VA+) on left ventricular (LV) function in dilated cardiomyopathy (DCM) patients using cardiovascular magnetic resonance (CMR) feature tracking (FT). 34 VA+ and 39 VA- (benign) DCM patients were measured with CMR cine imaging. Although the left ventricular ejection fraction was similar between these two groups, FT results showed the global longitudinal peak strain (GLS) was significantly lower in VA+ than in VA-. GLS had certain diagnostic value for differentiate VA+ and VA- in DCM patients. Glycosylated hemoglobin (HBA1c) was an independent determinant parameter for GLS in DCM patients.

View Presentation Video

Yurie Shirai¹, Michinobu Nagao², Atsushi Yamamoto¹, Kei Inai³, Takeshi Shinkawa⁴, Seiko Shimizu⁵, and Shuji Sakai^1
1Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University, Shinjuku, Japan, ²Tokyo Women’s Medical University, Shinjuku, Japan, ³Pediatric Cardiology, Tokyo Women’s Medical University, Shinjuku, Japan, ⁴Cardiovascular Surgery, Tokyo Women’s Medical University, Shinjuku, Japan, ⁵Canon Medical, Chuo, Japan

Keywords: Heart, Cardiovascular

In patients with repaired tetralogy of Fallot (TOF), pulmonary regurgitation is a frequent complication, resulting in right heart failure. Pulmonary valve replacement (PVR) should be performed before irreversible heart failure occurs. Pulmonary regurgitation disappears and RV volume decreases with PVR. Interventricular interactions are expected to improve left ventricular (LV) function, but in some cases LV function is not restored. We analyzed pre- and post-PVR cine cardiac MRI (CMR) with a motion tracking technique to quantitatively assess LV deformity in three dimensions. As a result, a decrease in preoperative LV torsion was a useful predictor of postoperative worsening LV function.

View Presentation Video

Justin Poon^1,2, Richard B Thompson³, Marc W Deyell⁴, Devin Schellenberg⁵, Kirpal Kohli⁶, and Steven Thomas^2
1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Department of Medical Physics, BC Cancer - Vancouver, Vancouver, BC, Canada, ³Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ⁴Heart Rhythm Services and Centre for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada, ⁵Department of Radiation Oncology, BC Cancer - Surrey, Surrey, BC, Canada, ⁶Department of Medical Physics, BC Cancer - Surrey, Surrey, BC, Canada

Keywords: Arrhythmia, Radiotherapy, cardiac radioablation

Cardiac magnetic resonance (CMR) images and tracked left ventricle (LV) contour points were used to investigate the advantages of a cardiac-gated radioablation treatment for ventricular tachycardia. Contour points were divided into 17 segments of the LV. Individual segments were treated as hypothetical targets, and an optimal treatment window was determined where cardiac motion was minimal. Target centroid displacement and treatment area were quantified for the treatment window and the full cardiac cycle. Using a cardiac-gated radioablation treatment would allow for reduced treatment margins and minimize the dose delivered to surrounding normal tissue.

View Presentation Video

Lu Tang¹ and Jiayu Sun^1
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Keywords: Heart, Myocardium, obesity; left ventricular function; cardiac magnetic resonance

This study investigate left ventricular function of obese patients with no known heart disease who underwent laparoscopic sleeve gastrectomy (LSG) by cardiac magnetic resonance (CMR) in their short- and mid-term postoperative follow-up. We found that obese patients who underwent LSG had a significant decrease in body weight, left ventricular mass and left ventricular cavity in the short- and mid- term postoperative. In the mid-term postoperative, the left ventricular subclinical systolic dysfunction of left ventricle significantly improved.

View Presentation Video

Maria Gusseva^1,2,3, Daniel A. Castellanos⁴, Tarique Hussain¹, Dominique Chapelle^2,3, and Radomír Chabiniok^1,2,3,5
1Department of Paediatrics, UT Southwestern Medical Center, Dallas, TX, United States, ²Inria, Palaiseau, France, ³Ecole Polytechnique, Palaiseau, France, ⁴Department of Cardiology, Boston Children’s Hospital, Boston, MA, United States, ⁵Czech Technical University in Prague, Prague, Czech Republic

Keywords: Heart, Modelling

Clinical pressure-volume data are often subjected to measurement noise. In the present work we explore the potential of a biomechanical model of the heart as a data-filtering tool. We use cardiovascular MRI volume data either simultaneously or sequentially acquired with catherization. We use time-varying elastance metrics for a quantitative comparison of data- and model-derived pressure-volume loops (PV loops). Our results demonstrate that the biomechanical model provides high quality PV loops that could be used to replace noisy data signals. In addition, this work contributes to the increased understanding of cardiovascular MRI results. 

View Presentation Video

Jacob Goes^1,2, Vivian S Nguyen^1,2, Donovan Gorre³, Timothy J Carroll³, Jihye Jang⁴, Marcella K Vaicik¹, Jouke Smink⁵, Amit R Patel⁶, Jeremy A Silvnick², and Keigo Kawaji^1,2
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Medicine - Cardiology, University of Chicago Medical Center, Chicago, IL, United States, ³Radiology, University of Chicago Medical Center, Chicago, IL, United States, ⁴Philips, Gainesville, FL, United States, ⁵Philips, Best, Netherlands, ⁶Medicine, University of Virginia, Charlotesville, VA, United States

Keywords: Myocardium, Preclinical

A single-breath-held (BH) cine and tag MRI offers a hybrid SSFP-SPGR contrast approach with potential to provide quantitative measures of regional myocardial wall motion. Such approaches overcome the need for inter-BH misregistration during conventional, multi-sequence acquisition. In this study, we examine the extent of artifact interferences that manifest by means of the bypassed pre-scan calibration steps for the less sensitive SPGR-tag scan. A consecutive cohort of 25 subjects that yielded ~400 cine- and tag-volumes were retrospectively analyzed to examine the prevalence of artifact, interference with motion assessment, and the rate of yielding assessable wall motion via the hybrid one-breath-hold approach.

Zhaozhao Wang¹, Anqi Yang¹, Zien Zhou², Chi Wang³, Jing An⁴, and Yi He^1
1Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, ²Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Heart Health Research Center, Beijing, China, ⁴Siemens Shenzhen Magnetic Resonance Ltd., Beijing, China

Keywords: Heart, Heart

SSFP-cine CMR imaging has been recommended to evaluate LV function and structure. However, a long scan time limited its widely application. A novel fast CS-cine CMR imaging might be an option, but its accuracy is inconclusive. Therefore, we conducted a systematic review and meta-analysis for it. We included 23 observational studies for pooling. There was no difference in LVEF, LVEDV, LVESV and LVmass, along with no heterogeneity across different subgroups by MR field intensity, breath-holding, children,  and arrhythmia (all P for inter-subgroup heterogeneity <0.05).  The quality of CS-cine images was acceptable and was superior to SSFP-cine images in arrhythmia patients. 

View Presentation Video

YINGMIN LIU¹, Donel Tani², Matthew Joseph¹, Nael F. Osman², Mahmood Khan¹, Juliet Varghese¹, and Orlando P. Simonetti^1
1Ohio State University, Columbus, OH, United States, ²Myocardial Solutions, Inc., Morrisville, NC, United States

Keywords: Cardiomyopathy, Low-Field MRI, Strain

In phantom, human volunteers, and an animal model, this study shows the feasibility of strain encoding (SENC) on a commercially available 0.55T low field scanner with limited gradient performance. Measured through-slice strain in a deformation phantom agrees with steady-state free precession (SSFP) cine; global strains in healthy humans fall into the normal expected range; infarcted myocardial segments in a porcine model demonstrated reduced strain.

Sainan Cheng¹, Jianwei Wang¹, Yawen Wang¹, Linlin Qi¹, Fenglan Li¹, Jianing Liu¹, Jiaqi Chen¹, Yang Fan², and Lizhi Xie^2
1Department of Diagnostic Radiology, National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²MR Research China, GE Healthcare, Beijing, China

Keywords: Heart, Cardiovascular, cardiotoxicity

This study explored the early cardiac changes in HER2-positive patients treated with HER2-targeted or anthracycline therapy through cardiac MRI. The results showed frequent signs of subclinical cardiotoxicity after short-term anti-cancer therapy, despite with low-moderate cardiovascular risk. T1 mapping showed the capability for early detection of pathological myocardial changes before cardiac contractile dysfunction. In HER2-positive breast cancer patients, cardiotoxicity surveillance is important and should be carefully done even with low-moderate cardiovascular risk, especially for those received anthracycline-based therapy.