ISMRM23 - So You’ve Got ASL Data … Now What?

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

So You’ve Got ASL Data … Now What?

Member-Initiated Tutorials

Thursday, 08 June 2023

716A/B

13:45 - 15:45

Moderators: Nikou Damestani & Patricia Figueiredo

Session Number: MIST-07

No CME/CE Credit

Organizers: Nikou Damestani, Patricia Figueiredo & Joseph Woods

Overview:
This tutorial was proposed by the Perfusion study group.

The use of arterial spin labeling (ASL) has dramatically increased in recent years. In 2015, the ISMRM Perfusion Study Group published a consensus paper describing a simple, yet robust, ASL sequence and perfusion quantification approach that was instrumental for leading this increase. Since then, there has been growing interest in more advanced ASL methods that enable the quantification of parameters beyond perfusion. The perfusion study group is in the process of publishing five “gray papers,” providing guidance and advice on a range of these more advanced methods, including multi-timepoint and velocity selective ASL. This tutorial is well timed to compliment the emergence of these consensus papers and increase the accessibility of advanced ASL analysis methods.

This tutorial consists of three parts: (1) the first lecture will provide an overview of how the ASL signal can be modeled and how this can be used to estimate multiple physiological parameters including perfusion, as well as arterial transit time (ATT), arterial blood volume, and blood-brain barrier exchange rates; (2) the second lecture will describe the information and resources that the Open Science Initiative for Perfusion Imaging (OSIPI) has put together about publicly available ASL processing pipelines and software; (3) the final four presentations will demonstrate how to process ASL data with four commonly used pipelines from start to finish, equipping attendees with the know-how to analyze their own data.

Target Audience:
Scientists, engineers, clinical researchers, and radiologists who are interested in understanding how to process ASL data from scratch.

As a result of attending this course, participants should be able to:
- Explain the theory behind the most common signal modeling approaches used to analyze ASL data;
- Identify where to find the information and resources that OSIPI has gathered, helping researchers to choose and find the right processing pipeline to use; and
- Describe how to process ASL data with four publicly available ASL analysis software.

13:45		Basic Principles: Quantification of Multi-Timepoint ASL & Velocity-Selective ASL Meher Juttukonda A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
14:05		Processing Multi-Timepoint ASL Data Using BASIL Moss Zhao Stanford University
14:25		OSIPI Pipeline & Software Inventory Maria Mora UT Southwestern
14:45		Processing Single- & Multi-Delay ASL Data Using the LOFT ASL Toolbox Chenyang Zhao University of Southern California
15:05		Processing Single-PLD ASL Data Using ASLPrep Sudipto Dolui University of Pennsylvania
15:25		Processing Multi-PLD Multi-TE Blood-Brain Barrier ASL Data Using ExploreASL Beatriz Padrela Amsterdam UMC