View Presentation Video

Milan Speth^1,2, Till Frederik Kaireit^1,2, Marcel Gutberlet^1,2, Filip Klimeš^1,2, Lea Behrendt^1,2, Andreas Voskrebenzev^1,2, Frank Wacker^1,2, Tobias Welte^2,3, Jens Gottlieb^2,3, and Jens Vogel-Claussen^1,2
1Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Keywords: Lung, Transplantation, Graft loss

Aim of this prospective single-center surveillance study was to assess the ability of oxygen-enhanced MRI to predict future chronic lung allograft dysfunction (CLAD) related transplant loss. Baseline MRI scans were acquired 6-12 months and follow-up MRI 2.5 years after double lung transplantation. T1 mapping was carried out with patients breathing room air and 100% oxygen, Delta T1 maps were calculated. Median, quartile coefficient of dispersion and ventilated volume parameters were correlated with graft loss and compared with same day lung function testing. Oxygen-enhanced MRI predicted future CLAD-related transplant loss 6-12 months post transplantation and, when evaluating %change, at follow-up MRI.

View Presentation Video

Marta Tibiletti¹, Christopher Short^2,3, Josephine H Naish^1,4, Mary Abkir^2,3, Thomas Semple^2,3,5, Simon Padley^2,3, Jane C. Davies^2,6, and Geoff JM Parker^1,7
1Bioxydyn Ltd, Manchester, United Kingdom, ²National Heart & Lung Institute, Imperial College London, London, United Kingdom, ³Royal Brompton Hospital, Guy's & St Thomas’ Trust, London, United Kingdom, ⁴MCMR, Manchester University NHS Foundation Trust, Wythenshawe, United Kingdom, ⁵Centre for Paediatric and Child Health, Imperial College London, London, United Kingdom, ⁶Royal Brompton Hospital, , Guy's & St Thomas’ Trust, London, United Kingdom, ⁷Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Keywords: Lung, Oxygenation

This study presents the first results from a population with cystic fibrosis (CF) of a novel, easy-to-implement, multi-slice, free breathing OE-MRI acquisition method based on measuring R₂* changes in the lung with varying level of oxygen delivered to the patients.

The oxygen ventilated volume fraction obtained presents a very good correlation with lung clearance index (LCI) obtained by multiple breath N₂ washout. LCI is a marker of overall lung ventilation inhomogeneity, which has been shown to be a sensitive marker of lung disease severity in CF, particularly in the early stage of the disease when spirometry outcomes are normal.

View Presentation Video

Laura Saunders¹, Guilhem Collier¹, Ho-Fung Chan¹, Paul Hughes¹, Laurie Smith¹, Neil Stewart¹, Jonathan Brooke², James Watson³, James Meiring³, Zoë Gabriel³, Thomas Newman³, Megan Plowright³, Phillip Wade³, James Eaden³, Jody Bray¹, Helen Marshall¹, David Capener¹, Leanne Armstrong¹, Jennifer Rodgers¹, Martin Brook¹, Alberto Biancardi¹, Madhwesha Rao¹, Graham Norquay¹, Oliver Rodgers¹, Ryan Munroe¹, James Ball¹, Neil Stewart¹, Gisli Jenkins⁴, James Grist⁵, Kher Lik Ng⁶, Ling-pei Ho⁵, Fergus Gleeson⁵, Ian Hall⁷, Thomas Meersmann⁷, Galina Pavlovskaya⁷, Arthur Harrison⁷, Jonathan Brooke⁷, Joseph Jacob⁸, Andrew Swift¹, Smitha Rajaram³, Gary Mills¹, Lisa Watson³, Paul Collini¹, Rod Lawson³, A A Roger Thompson¹, and Jim Wild^1
1The University of Sheffield, Sheffield, United Kingdom, ²University of Nottingham, Nottingham, United Kingdom, ³Sheffield Teaching Hospitals, Sheffield, United Kingdom, ⁴Imperial College London, London, United Kingdom, ⁵University of Oxford, Oxford, United Kingdom, ⁶Oxford NHS Foundation Trust, Oxford, United Kingdom, ⁷Nottingham University, Nottingham, United Kingdom, ⁸University College London, London, United Kingdom

Keywords: Lung, COVID-19

Patients with signs of interstitial lung disease at 12 weeks after hospitalisation due to COVID-19 underwent ¹H and ¹²⁹Xe MRI. ¹²⁹Xe MRI showed impaired xenon gas transfer (RBC:M and RBC:gas) at 24 and 52 weeks after hospital admission, with no longitudinal change between 24 and 52 weeks observed in ¹²⁹Xe MRI metrics or PFT transfer factor.  Xenon MRI metrics correlated significantly with PFT transfer factor at 24 weeks (RBC:M, RBC:gas, Lm_D) and 52 weeks (RBC:M, RBC:gas, Lm_D).

View Presentation Video

Keywords: Lung, COVID-19

Gas exchange hyperpolarized ¹²⁹Xe MRI (Xe-MRI) is increasingly being considered as an outcome measure in multi-site clinical trials, but there is limited evidence of between-site comparability. In this study, we analyzed 121 gas exchange Xe-MRI images in healthy and post-acute COVID-19 participants independently acquired at three sites. In healthy volunteers, quantitative Xe-MRI measures are indistinguishable across sites. In post-acute COVID-19, cross-site differences in Xe-MRI measures are evident but appear to be driven by differences in patient population. Moreover, Xe-MRI measures across sites correlate strongly with pulmonary function testing. These results support the feasibility of multi-site trials using gas exchange Xe-MRI.

View Presentation Video

Junlan Lu¹, Elianna Bier², Suphachart Leewiwatwong², David Mummy³, Sakib Kabir³, Fawaz Alanezi⁴, Sudarshan Rajagopal⁴, Scott Haile Robertson⁵, Peter J Niedbalski⁶, and Bastiaan Driehuys^3
1Medical Physics, Duke University, Durham, NC, United States, ²Biomedical Engineering, Duke University, Durham, NC, United States, ³Radiology, Duke University, Durham, NC, United States, ⁴Cardiology, Duke University, Durham, NC, United States, ⁵Clinical Imaging Physics Group, Duke University, Durham, NC, United States, ⁶Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, United States

Keywords: Lung, Hyperpolarized MR (Gas), CTEPH, keyhole reconstruction

Dynamic spectroscopy of hyperpolarized ¹²⁹Xe in red blood cells exhibits cardiopulmonary oscillations that can be used to detect both pre- and post-capillary pulmonary hypertension (PH). However, this whole-lung measurement cannot resolve spatially heterogeneous variations in oscillations. This limitation can be addressed by using keyhole reconstruction approaches to spatially resolve the oscillations. Here we demonstrate several extensions of this technique that make both the reconstruction and analysis more robust. We have used this to establish updated healthy reference distributions and demonstrate the utility of spatially resolved mapping in a cohort of patients with chronic thromboembolic pulmonary hypertension pre- and post-thromboendarterectomy.

View Presentation Video

Keywords: Vessels, Quantitative Imaging, lymphangiography

A lack of clinical quantitative lymphatic metrics slows progress for innovation in treatment of lymphatic disease. MR lymphangiography provides high resolution anatomic analysis of the lymphatic system necessary for guiding new and emerging therapeutics but has not been explored as a quantitative metric. We coupled MR lymphangiography with iron oxide nanoparticles as the contrast agent and demonstrate the time to visualization of the thoracic duct is decreased in patients with bilateral lymphedema. Additionally, the change in R2* of inguinal lymph nodes after transpedal contrast injection quantifies lymphatic transit in patients with lymphedema.

Yoshiharu Ohno^1,2, Masao Yui³, Kaori Yamamoto³, Masato Ikedo³, Yuka Oshima⁴, Nayu Hamabuchi⁴, Satomu Hanamatsu⁴, Hiroyuki Nagata², Takahiro Ueda¹, Hirotaka Ikeda¹, Daisuke Takenaka^1,5, Takeshi Yoshikawa^1,5, Akiyoshi Iwase⁶, Yoshiyuki Ozawa¹, and Hiroshi Toyama^1
1Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ²Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan, ³Canon Medical Systems Corporation, Otawara, Japan, ⁴Fujita Health University School of Medicine, Toyoake, Japan, ⁵Diagnostic Radiology, Hyogo Cancer Center, Akashi, Japan, ⁶Fujita Health University Hospital, Toyoake, Japan

Keywords: Lung, Cancer

We hypothesized that pulmonary MRIs with UTE using single- or dual-echo techniques may be equal to or more useful than standard-dose thin-section CT for evaluating solid portion size and C/T ratio.  The purpose of this study was thus to compare capabilities of pulmonary MRIs with UTE using single- and dual-echo techniques (UTE-MRI_Single and UTE-MRI_Dual) and thin-section CT for quantitative differentiation of non- and minimally invasive adenocarcinomas from other lung cancers.   

View Presentation Video

Nathalie Barrau¹, Adrien Duwat¹, Killian Sambourg¹, Angéline Nemeth¹, Antoine Beurnier², Tanguy Boucneau³, Vincent Lebon¹, and Xavier Maître^1
1Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France, ²Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France, ³GE Healthcare, Buc, France

Keywords: Lung, Quantitative Imaging, Spirometry

Three-dimensional MR spirometry fosters a double paradigm shift upon standard spirometry: from forced to free breathing and from global to local measurements. The technique makes use of voxel-wise flow-volume loops and original biomechanical markers to characterize the regional lung function. Over a diverse adult population, nominal common features showed up throughout 3D MR spirometry parametric maps in healthy volunteers spontaneously breathing in supine and prone positions.  Euclidian barycenter and standard deviation maps of local tidal volumes, spontaneous expiratory peak flows, and anisotropic deformation indices are presented here as the ground for a unique atlas of the lung function.

Yoshiharu Ohno^1,2, Masao Yui³, Kaori Yamamoto³, Takeshi Yoshikawa^1,4, Daisuke Takenaka^1,4, Masato Ikedo³, Akiyoshi Iwase⁵, Yuka Oshima⁶, Nayu Hamabuchi⁶, Satomu Hanamatsu⁶, Hiroyuki Nagata², Takahiro Ueda¹, Hirotaka Ikeda¹, Yoshiyuki Ozawa¹, and Hiroshi Toyama^1
1Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ²Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan, ³Canon Medical Systems Corporation, Otawara, Japan, ⁴Diagnostic Radiology, Hyogo Cancer Center, Akashi, Japan, ⁵Fujita Health University Hospital, Toyoake, Japan, ⁶Fujita Health University School of Medicine, Toyoake, Japan

Keywords: Lung, Cancer, CEST

We hypothesize that CEST imaging has a potential for therapeutic outcome prediction in NSCLC patients treated with chemoradiotherapy and may play as one of the predictors in this setting.  The purpose of this study was to compare the capability for therapeutic outcome prediction among CEST imaging, DWI and FDG-PET/CT in NSCLC patients with conservative therapy.

View Presentation Video

Keywords: Lung, Low-Field MRI

Recently, ultrashort echo time (UTE) has gained renewed interest for lung imaging at 1.5T and 3T, which captures short T2* signal from lung parenchyma. Lower field is attractive for lung MRI due to prolonged T2* and reduced susceptibility, and it was demonstrated that high-resolution high-quality structural lung imaging can be achieved with UTE at 0.55T. In addition to anatomical information, pulmonary function such as regional ventilation is also of great clinical interest. In this study, we developed free-breathing respiratory-motion-resolved 4D pulmonary imaging using stack-of-spirals acquisition with compressed-sensing at both 0.55T and 3T, which could enable quantitative evaluation of ventilation dynamics.

View Presentation Video

Grzegorz Bauman^1,2, Nam G Lee³, Ye Tian⁴, Oliver Bieri^1,2, and Krishna S Nayak^3,4
1Deparment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States, ⁴Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States

Keywords: Lung, Low-Field MRI, Morphology

In this work we explore the potential of free-breathing balanced steady-state free precession half-radial dual-echo imaging technique (bSTAR) for morphologic lung MRI in human subjects using high-performance 0.55T MR-scanner. The technique combines an efficient minimal-TR readout sampling with interleaved wobbling Archimedean spiral pole trajectories and retrospective respiratory self-gating. Lung imaging at 0.55T helped to markedly reduce off-resonance artifacts while providing an improved signal intensity and allowed for high-quality morphologic lung MRI at a submillimeter spatial resolution.

 

View Presentation Video

Ye Tian¹, Nam G. Lee², Ziwei Zhao¹, and Krishna Nayak^1,2
1Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

Keywords: Lung, Lung

MRI provides radiation-free screening of many lung diseases. Its use has been limited at field strengths >1.5T, largely due to the ultra-shot T2* and low proton density in the lung. New 0.55T systems provide improved lung MRI capability since T2* is prolonged to the order of 10ms. In this work, we propose a rapid 3D bSSFP stack-of-spiral out-in (SoSoi) pulse sequence for lung imaging. The sequence can acquire 2 mm isotropic resolution image with 23 sec breathhold or 2.4 mm isotropic resolution image with 13 sec breathhold, both show great pulmonary vessels depiction.

View Presentation Video

Liping Liao¹, Zehe Huang¹, Zeping Liu², Shengyuan Liang¹, Lei Qin¹, Shengzhang Pan¹, Lanbin Huang¹, Qizeng Ruan¹, Yi Sun³, and Guoxi Xie^2
1The First People’s Hospital of Qinzhou, Qinzhou, China, ²School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, ³Siemens Healthineers, Shanghai, China

Keywords: Vessels, Thrombo-Embolic

Abdominal vein thrombosis (AVT) is a significant cause of morbidity. Accurate diagnosis of AVT is relevant for treatment proper decision-making. CTV or MRV requires the use of contrast medium, which may lead to patient's renal failure or allergic reaction. To address this issue, we sought to develop a direct AVT imaging (DATI) technique which is free of contrast medium. The technique is based on a respiratory navigating SPACE sequence with DANTE black-blood preparation and evaluated preliminarily on 19 AVT patients at 3.0T. Experiment results show that DATI can provide definitive thrombus detection for the diagnosis of AVT.

View Presentation Video

Sijie Zhong^1,2, Ran Tao¹, Ruoxi Wang^1,2, Hao Chen^1,2, Chen Jin^1,2, and Zhiyong Zhang^1,2
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China

Keywords: Vessels, Cardiovascular, Run-time MRI, Navigation, Interventional MRI

Cardiovascular dilation surgery is usually performed with DSA navigation, and excessive radiation during imaging harms both the patient and the physician. Magnetic resonance imaging can avoid ionizing radiation, but its imaging efficiency severely limits the performance of real-time imaging. Therefore, we construct a complete real-time magnetic resonance navigation system through continuous radial scanning mode and corresponding reconstruction methods and formulate a group of scanning strategies. The characteristics of the special derivative catheter under magnetic resonance imaging were tested by combining the partner's magnetically compatible robotic equipment. And the results demonstrated the feasibility of this method.