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Keywords: Tumors, Brain

This study sought to compare previously published autopsy-based radio-pathomic maps of pre-surgical cellularity and tumor probability to beyond-contrast 5-ALA guided resection margins to assess concordance in identifying non-enhancing tumor between the techniques. In a series of 10 cases, radio-pathomic maps were able to identify areas of non-enhancing tumor prior to surgery that coincided with either 5-ALA guided resection margins or areas of future recurrence in 7 of 10 cases, suggesting that highlighted areas on these maps indicate active, progressive tumor.

Jinli Li¹, Xianchang Zhang², Ruijun Yang¹, Quanzhi Feng¹, Dong Yuan¹, Jiajia Zhang¹, and Tong Han^1
1Tianjin Huanhu Hospital, No.6 Jizhao Road, Jinnan District, Tianjin 300350, China., Tianjin, China, ²MR Collaboration, Siemens Healthineers Ltd., Beijing, China., Beijing, China

Keywords: Tumors, Radiomics, brain invasion

This study aimed to construct a radiomic model based on a large patient cohort to predict brain invasion (BI) in meningioma. By analyzing 97 patients with BI and 935 patients without BI, we found that the clinical risk factors for BI were male sex, tumor located at the skull base, and peritumoral edema volume. A binary logistic regression model combining these risk factors and multimodal MRI radiological characteristics was established. The constructed model achieved an excellent performance (AUC: 0.928) in terms of BI classification with an accuracy of 91.77%, which may be helpful for personalized treatment plan in meningioma.

Hui Zheng¹, Lingmin Zheng¹, Zongmeng Wang¹, Rufei Zhang¹, Yang Song², and Lin Lin^1
1Fujian Medical University Union Hospital, Fuzhou, China, ²MR Scientific Marketing, Siemens, Healthineers Ltd., Shanghai, China

Keywords: Tumors, Diffusion/other diffusion imaging techniques

Prior investigators have found that diffusion weighted imaging (DWI) contributes to improving the prediction of postoperative recurrence of meningioma.  This study evaluated the feasibility of intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) in predicting postoperative recurrence of meningioma and compared them with DWI. Histogram metrics derived from DWI, IVIM, and DKI parameters were compared between the recurrent group and non-recurrent group. It was found that the lower ADC, D, f value and the higher D*, K value, the higher risk of postoperative recurrence of meningioma. However, IVIM and DKI derived parameters had similar diagnostic performance compared with DWI.

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Keywords: Tumors, Treatment

CEST MRI is a non-invasive molecular imaging approach, while APT has been applied to reveal molecular changes in brain tumors. Based on our theranostic hydrogel studies, here, we demonstrated the therapeutic effect on brain tumor with a continuous decrease in tumor size over 10 days. Importantly, the APT signal showed significant decrease on day 3 after treatment when tumor size did not have a significant change. Moreover, a strong correlation between APT signal and Ki-67 staining was shown. This could be a potential application to detect early tumor responses toward local hydrogel based treatment.

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Tongling Jiang¹, Minghao Wu², Cong Xie², Xianchang Zhang³, Yaou Liu², and Yi Zhang^1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³MR Collaboration, Siemens Healthineers Ltd., Beijing, China

Keywords: Tumors, Brain

APT-related metric maps were applied to differentiate subtypes and genotypes of adult-type diffuse gliomas following the latest 2021 WHO guidelines. One hundred and twenty-nine patients were imaged on a 3T scanner. Regions of interest were obtained with an automatic segmentation algorithm on conventional anatomical images, which were then resampled and matched with the CEST images. The mean CEST metric values were calculated in the automatically-defined regions of interest, and the receiver operating characteristic analysis was implemented, achieving generally successful performance in identifying the IDH status and part of the subtypes.

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Jacob Chen Ming Low¹, Jianbo Cao¹, Friederike Hesse¹, Alan Wright¹, and Kevin Brindle^1
1CRUK Cambridge Institute, Cambridge, United Kingdom

Keywords: Tumors, Deuterium

The potential for DMI measurements of deuterated glucose metabolism to differentiate between metabolic subtypes in GBM has been demonstrated in patient-derived xenografts in mice. The glycolytic subtype showed increased lactate labelling whereas two oxidative subtypes showed increased glutamate/glutamine (Glx) labelling. There was decreased lactate labelling in a glycolytic subtype and decreased lactate and Glx labelling in an oxidative subtype within 24 h after the completion of standard-of-care chemoradiotherapy, demonstrating that the technique can also be used to detect early treatment response in this tumor type.

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Hongquan Zhu¹, Yuanhao Li¹, Li Li¹, Weiyin Vivian Liu², and WenZhen Zhu^1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²GE Healthcare, MR Research China, Beijing, China

Keywords: Tumors, Brain, Glioma

Glioma could impair the glymphatic function with reduced CSF outflow. We aimed to use DTI-ALPS method to investigate the pathological change of glymphatic function in gliomas and evaluate its value in grading gliomas and predicting IDH1 mutation status. The lower-grade gliomas (LrGGs) showed higher ALPS Index than glioblastomas (GBMs). IDH1 wild-type group showed decreased ALPS Index compared with the IDH1 mutant group in LrGGs. But there was no difference between the IDH1 subtypes in GBMs. The ALPS Index showed good efficiency in grading gliomas and predicting IDH1 mutation status, it may be a potential imaging biomarker for diagnosing gliomas.

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Giovanni Sighinolfi¹, Laura Ludovica Gramegna^1,2, Alessandro Carrozzi¹, Cristiana Fiscone¹, Matteo Zoli^1,2, Diego Mazzatenta^1,2, Claudia Testa^2,3, Raffaele Lodi^1,2, Caterina Tonon^1,2, and David Neil Manners^1
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ²IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ³Department of Physics and Astronomy, University of Bologna, Bologna, Italy

Keywords: Tumors, Tractography & Fibre Modelling, Anterior Optic Pathway

Tumors of the sellar/paraellar region are likely to displace the optic chiasm, making it valuable to study the entire course and microstructural properties of the anterior optic pathway (AOP, including optic nerves, chiasm and optic tracts). We present the first fully automated tractography pipeline to entirely reconstruct the AOP. The pipeline was applied on a group of patients with sellar/parasellar tumors displacing the chiasm, achieving excellent reliability. We also estimated mean diffusivity, fractional anisotropy and fiber density along the AOP, demonstrating alterations in patients compared to controls, which we explain based on chiasmal compression.

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Keni Zheng¹, Matthew C. Murphy ¹, Emanuele Camerucci ¹, Xiang Shan¹, Yi Sui¹, Armando Manduca ², Jamie J. Van Gompel³, Richard L. Ehman ¹, John III Huston¹, and Ziying Yin^1
1Radiology, Mayo Clinic, Rochester, MN, United States, ²Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, ³Neurosurgery, Mayo Clinic, Rochester, MN, United States

Keywords: Tumors, Brain, Meningiomas, tumor stiffness, tumor adhesion, slip interface imaging, tumor recurrence, tumor resection

This work explored the value of MR elastography (MRE)-measured tumor stiffness and slip interface imaging (SII)-assessed adhesion metrics in predicting the extent of tumor resection and the probability of meningioma recurrence in 52 patients with meningiomas. Tumor adhesion percentage was assessed based on pattern recognition of the normalized octahedral shear strain (NOSS) map. Tumor stiffness was calculated using a neural network-based inversion (NNI). We found that stiffness correlates with the extent of resection (EOR) that was possible at surgery, while the extent of tumor adhesion showed good correlation with tumor recurrence among aggressive tumors with atypical features.

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Keywords: Tumors, Tumor

We tested the hypothesis that autopsy-based radio-pathomic maps of glioblastoma pathology reveal distinct phenotypes (hypercellular, hypocellular, hybrid, and well-circumscribed fronts) that differ in patient survival and bevacizumab treatment response. Patients with tumor invasion beyond contrast showed worse survival outcomes compared to patients with well-circumscribed tumors. Additionally, patients with hypocellular components of the non-enhancing front selectively benefit from bevacizumab treatment, with an observable reduction in the hypocellular volume over the course of bevacizumab use.

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Eryuan Gao¹, Guohua Zhao¹, Huiting Zhang², Peipei Wang¹, Xiaoyue MA¹, Jie Bai¹, Xu Yan², Guang Yang³, and Jingliang Cheng^1
1Department of Magnetic Resonance, the First Affliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Shanghai, China, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

Keywords: Tumors, Neuro, atypical high-grade glioma, primary central nervous system lymphoma

Preoperative differentiation of atypical high-grade glioma (HGG) (with no or little necrosis) and primary central nervous system lymphoma (PCNSL) may help to develop treatment plans. However, they share similar appearance in routine MR images. As a new diffusion model, neurite orientation dispersion and density imaging (NODDI) reflects the microstructure of tissue by measuring different components within it. Through quantitative analysis, we found that all parameters of NODDI performed excellent in distinguishing between atypical HGG and PCNSL.

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Maria Ljungberg^1,2, Oscar Jalnefjord^1,2, Isabelle Rydén³, Erik Fernström⁴, Linnea Andersson^1,2, Justin Schneiderman³, Malin Blomstrand⁴, Marie Kalm⁵, Isabella Björkman-Burtscher⁶, and Marianne Jarfelt^4
1Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁵Department of Pharmacology, Institute of Neuroscience and Physiology , Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁶Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Keywords: Tumors, Radiotherapy, DTI, MR spectroscopy

Cranial radiotherapy (CRT) is effective; however, survivors of childhood cancer often suffer from cognitive deficits. Two adult patient groups that received different CRT exposures as children were included, as well as healthy volunteers. The MR-examination comprised of anatomical imaging, DTI and MR spectroscopy of the hippocampus. Differences were found between the group that received highest CRT dose and the control group in hippocampal volume, tNAA/tCr-ratio of hippocampus and several DTI-measures in e.g., corpus callosum. Correlations was found between DTI-measures (MD/RD/AD) in some of the studied white matter tracts and several of the used neuropsychological tests, e.g., BVMT-R Sum and Coding.

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Jianan Zhou^1,2,3, Wentao Hu⁴, Zhengyang Zhu⁵, Xin Zhang^1,2,3, Yongming Dai⁴, and Bing Zhang^2,3,5,6,7
1Department of Radiology，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing,Jiangsu Province,China, China, ²Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China, ³Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, ⁴MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China, Shanghai, China, ⁵Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing,Jiangsu Province,China, China, ⁶Jiangsu Key Laboratory of Molecular Medicine, Nanjing, China, ⁷Institute of brain Science, Nanjing University, Nanjing, China

Keywords: Tumors, Contrast Agent

The immunohistochemistry features of glioblastoma have important influence on its occurrence and prognosis. Understanding the noninvasive detection of interstitial fluid pressure (IFP) and velocity (IFV) based on dynamic contrast enhanced (DCE)-MRI to explore the correlation between IFP and IFV with immunohistochemical markers of glioblastoma. The investigation demonstrates that IFP indicators have significant correlation with isocitrate dehydrogenase 1 (IDH1) expression and Ki-67 level of glioblastoma, and could help diagnose IDH1-mutation patients.

 Keywords

 Glioblastoma，Interstitial Fluid Pressure and Velocity，IDH1，Ki-67

Xueqin Wang¹, Xinru Shu², Pingping He³, Yang Song⁴, and Rifeng Jiang^5
1School of Medical Imaging, Fujian Medical University, Fujian, China, ²School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China, ³School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian, China, ⁴SIEMENS Healthcare, Diagnostic Imaging, Shanghai, China, ⁵Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

Keywords: Tumors, Nervous system

To date, few studies have investigated the association between ADC values and tumor subtypes of adult-type diffuse gliomas based on WHO CNS5. By comparing standard, high and ultra-high b value DWI, our research found that all ADC values can differentiate IDH genotypes with ADC_8,000 having the highest AUC of 0.827, and mostly ADC values can differentiate the tumor subtypes of gliomas, with ADC_8,000 and ADC_4,000 having the highest AUC of 0.780 and 0.902, respectively. High and ultra-high b value DWI, is a potent approach in identifying IDH genotype and tumor subtype of adult-type diffuse gliomas based on WHO CNS5.

 

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Andrada Ianus¹, Marco Palombo^2,3, Rui V. Simoes^1,4, Rafael N. Henriques¹, Tania Carvalho¹, and Noam Shemesh^1
1Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, ²Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, ³School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, ⁴Institute for Research & Innovation in Health (i3S), University of Porto, Porto, Portugal

Keywords: Tumors, Diffusion/other diffusion imaging techniques

Diffusion MRI (dMRI) provides an indirect characterisation of tissue features at the microscopic-scale. The Soma and Neurite Density Imaging (SANDI) methodology was initially proposed to quantity parameters of cell soma and neurite in brain white and gray matter. Here, we investigate the potential of employing SANDI as a general representation of isotropic, restricted, highly anisotropic and isotropic Gaussian components in two mouse models of glioma, derived from two cell lines with distinct microstructure (CT2A and GL261). The results reveal differences across the two tumour subtypes which are consistent with qualitative histological assessment.