ISMRM23 - Tuesday Plenary

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Tuesday Plenary

Plenary Session

ORGANIZERS: Seena Dehkharghani, Rita Schmidt, Khin Tha

Tuesday, 06 June 2023

Plenary Hall - Exhibit Halls F/G

10:30 - 12:00

Moderators:
11:00 - 12:00 Mind the Gap: From Magnetic to Electrical & Other Physical Properties of Biologic Tissues: Seena Dehkharghani & Rita Schmidt & Khin Tha

Session Number: P-02

Full Session Video

CME Credit

Session Number: P-02

Overview
The use of MRI in clinical and bioscientific applications in recent decades has proliferated and brought with it the advancement of neuroscience and the care of patients, from “bench-to-image-bedside”. Other candidate approaches to the characterization of biological tissues, including tissue electrical properties, arising from distinct but related physical features, have faced challenges to formalization and dissemination in scientific and clinical practice despite potential advantages. This presentation will establish the fundamental basis of tissue electrical properties, its interrelation and differences from magnetic properties, hardware and experimental design considerations for its interrogation, and the recent growth in pre-clinical and early clinical use.

Target Audience
Imaging scientists interested in understanding the relationship and differences with interrogating magnetic and electrical properties, and translational and clinical scientists interested in learning the potential applications of techniques probing electrical properties to diagnose and understand neurologic disease.

Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the basic physical principles of electrical properties, including their relationship and differences from magnetic properties

-Review the techniques, environment, and instrumentation used to probe electrical properties in bioscientific research at varying frequencies

-Discuss existing and potential future applications in translational, preclinical, and clinical science.

		NIBIB New Horizons Lecture
10:30		Brain Tumor Imaging & AI: A Clinical Imaging Biomarker Roadmap No Video Available Ji Eun Park Keywords: Cross-organ: Cancer, Image acquisition: Multiparametric, Transferable skills: Value Brain tumor imaging is a test bed for various image biomarkers (IBs), including the current new IB of artificial intelligence (AI). However, while some IBs are routinely used for testing and clinical decision-making for patients, most IBs are not. Why? New IBs must surpass the translational cap to be used as a clinical decision-making tool, and this follows a clinical roadmap. By presenting various clinical scenarios of IBs that have adopted, this will demonstrate a clinical roadmap of IBs in brain tumors and how they can become the next decision-making tool, including both IBs and AI.
		Mind the Gap: From Magnetic to Electrical & Other Physical Properties of Biologic Tissues
11:00		Tissue Electrical Properties: Principles & Their Relation to Magnetization No Video Available Rosalind Sadleir Keywords: Contrast mechanisms: Non-proton, Transferable skills: Metrology of MRI, Physics & Engineering: Multimodal MRI is increasingly used to provide quantitative measurements and images of electromagnetic property contrasts. Effects of tissue susceptibility and electrical conductivity properties become more apparent as main magnetic fields increase. Electrical properties contain rich information about the microscopic tissue environment and membrane structure in addition to ionic composition. We will describe the spectral properties and contrasts of tissues; explain how MR sequences can be adapted to isolate them, and how they can be analyzed; and show how these properties can potentially enhance understanding of normal and pathological processes.
11:30		Detection & Imaging of Tissue Electrical Properties No Video Available Leeor Alon
12:00		Imaging & Sensing of Dielectric Properties of the Brain: Novel Functional Diagnostics No Video Available Serguei Semenov Keywords: Contrast mechanisms: Electromagnetic Tissue Properties, Physics & Engineering: Multimodal, Neuro: Brain With the rise of magnetic T and increase in RF frequency in MRI, there is need for understanding of electromagnetic field distribution within biological objects. It requires the knowledge of magnetic and dielectric properties. The first portion of the talk is on dielectric properties of tissues, with an emphasis on brain tissues. Dielectric properties of tissues are sensitive to hypoxia, blood content, ischemia, stroke and malignancies. It opens up an opportunity for novel functional imaging modality - microwave tomography. The second part of the talk is on particulars of the technology, complementarity with MRI, results achieved and new horizons in applications.