ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

ISMRM & ISMRT Annual Meeting & Exhibition

Sunrise Course

Leaky Gut, Leaky Brain in Dementia? From Microbiome to Blood-Brain Barrier

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Leaky Gut, Leaky Brain in Dementia? From Microbiome to Blood-Brain Barrier
Sunrise Course
ORGANIZERS: Wei-Tang Chang, Audrey Fan, Xiao-Qi (Juliana) Huang
Wednesday, 07 June 2023
701A
07:00 -  08:00
Moderators: Leonardo Rivera-Rivera & Yu-Chien Wu
Skill Level: Intermediate to Advanced
Session Number: S-W-01
CME Credit

Session Number: S-W-01

Overview
In this four-day Sunrise course, the role of neuroinflammation related to tumors, autoimmune diseases, neurological diseases, and psychiatric disorders will be discussed each morning with a focus on clinical cases.

Target Audience
Physicians in the related field will be introduced to new techniques and cutting-edge topics about neuroinflammation in tumors, autoimmune diseases, neurological diseases, and psychiatric disorders and how imaging can help with the relevant clinical practice.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain how to image neuroinflammation in clinical conditions with case studies;
- Describe what neuroinflammation can do on the prognosis of those conditions; and
- Explain some basic mechanism related to neuroinflammation in those conditions.

07:00 Blood-Brain Barrier Dysfunction in Neurological Diseases Danny Wang

Keywords: Neuro: Brain function, Contrast mechanisms: Perfusion, Image acquisition: Quantification

Blood-brain barrier (BBB) plays a critical role in the delivery of oxygen and nutrients to the brain, clearance of toxic metabolites, and protection of the central nervous system (CNS) from infection. Impaired BBB function is implicated in a number of serious CNS diseases, such as multiple sclerosis, stroke, brain tumors, Alzheimer's disease and small vessel disease. Assessment of BBB permeability commonly relies on dynamic contrast enhanced MRI using Gd-based contrast agents. Recently, contrast and non-contrast MRI methods have emerged to assess BBB water exchange. The combination of these MRI methods has revealed the mechanism of BBB dysfunction in neurological disorders. 
07:30   Gut Microbiota in Dementia Qin Chen
 

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.