ISMRM23 - Molecular/Metabolic Imaging

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Molecular/Metabolic Imaging

Weekend Course

ORGANIZERS: Yasuhiko Tachibana, Shaihan Malik, Alex Tze Lun Leong

Saturday, 03 June 2023

717A/B

08:00 - 11:45

Moderators: Claudia Gandini Wheeler-Kingshott & Masaya Takahashi

Skill Level: Basic to Advanced

Session Number: WE-06

CME Credit

Session Number: WE-06

Overview
This session on molecular and metabolic MRI aims to provide a broad overview of key methods and applications, with a view to the past, present and future. The major topics considered are spectroscopy and spectroscopic imaging, multinuclear and hyperpolarised MRI, CEST, PET-MR and a brief overview of agents used for metabolic MR.

Target Audience
Scientists and clinicians who are interested in understanding, advancing, and/or applying molecular MR imaging in preclinical and/or clinical research.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the different contrast mechanisms and imaging techniques available for molecular MRI;
- Examine and explain the different probes available for molecular MRI; and
- Select suitable molecular MR imaging approaches for a given application either in basic science or for translational research.

08:00		Spectroscopy for Probing Metabolism View Presentation Video Jamie Near
08:25		Advances in Spectroscopic Imaging View Presentation Video Assaf Tal Keywords: Image acquisition: Sequences, Contrast mechanisms: Spectroscopic Imaging (MRSI) In this course I will provide an overview of magnetic resonance spectroscopic imaging (MRSI), its goals and the techniques that underlie it. The talk will begin with a brief historical perspective, discussing classical approaches such as chemical shift imaging (CSI), and then proceed to cover approaches to acceleration, including echo-planar based methods (EPSI), non-cartesian trajectories, undersampling, ultrashort TR acquisitions and model based reconstructions (SPICE). This course should provide participants with an introductory understanding of the current state-of-the-art in spectroscopic imaging, its pitfalls and possibilities.
08:50		Multinuclear Metabolic Imaging View Presentation Video Pavithra Viswanath
09:15		Hyperpolarized Metabolic Imaging View Presentation Video Jeremy Gordon Keywords: Contrast mechanisms: Hyperpolarization, Contrast mechanisms: Spectroscopic Imaging (MRSI) Hyperpolarized metabolic imaging has emerged as a novel non-invasive method to probe metabolism in near real-time. Due to the transient lifetime of the hyperpolarized magnetization and the need to resolve multiple metabolites, these contrast agents require special considerations when developing probes, designing pulse sequences, or considering potential pre-clinical and clinical applications. This presentation will cover the basics of hyperpolarized metabolic imaging, with a specific focus on applications in the clinic using ¹³C probes. Topics will include the unique properties of hyperpolarized contrast agents, imaging strategies to rapidly and robustly acquire spectroscopic data, and human applications of hyperpolarized metabolic imaging.
09:40		Break & Meet the Teachers
10:05		CEST: Physics & Technology View Presentation Video Anagha Deshmane Keywords: Contrast mechanisms: CEST & MT Chemical exchange saturation transfer or CEST is a family of MR technologies which can be used to interrogate protons bound in exogenous contrast agents or endogenous metabolites and macromolecules. This lecture introduces (1) the origin and mechanisms of CEST contrast, (2) models of CEST contrast using the Bloch-McConnell equations, (3) endogenous and exogenous targets available for producing CEST contrast, and (4) pulse sequences and post processing methods for acquiring and analyzing images with CEST contrast. The examples used in this lecture will focus on endogenous CEST contrast and clinical imaging techniques.
10:30		CEST: Journey to the Clinic View Presentation Video Jianpan Huang Keywords: Contrast mechanisms: CEST & MT CEST MRI has been increasingly explored and applied in multiple preclinical and clinical imaging centers worldwide. This lecture will introduce some recent progress and consensus on the clinical application of CEST MRI, especially the considerations regarding saturation and acquisition protocols to achieve high-quality and reproducible CEST measurements at multiple sites. Furthermore, there will be some discussions on the clinical trials using endogenous or exogenous CEST contrasts to provide molecular information for disease diagnosis and treatment monitoring. Specifically, a variety of CEST applications in imaging molecular events in brain tumors, neurological disorders and other parts of human body will be covered.
10:55		Agents for Metabolic Imaging View Presentation Video Petr Bednarík Keywords: Neuro: Nervous system The talk will focus on agents utilized for magnetic resonance spectroscopy and magnetic resonance imaging in advanced brain metabolic studies. 17O-MRS provides rate of oxygen inside mitochondria, whereas 19F-MRS enables measurement of cytosolic glucose metabolism. 13C-MRS is the only established noninvasive method to quantify both glutamatergic neurotransmission and cell-specific energetic pathways based on the type of 13C-enriched tracer. MRS utilizing deuterium(2H)-enriched compounds is a novel approach that promises to overcome 13C-MRS providing quantitative metabolic measures with high spatial resolution and affordable price. Overall, these MR methods demonstrate clinical translational potential to better understand brain disorders and guide diagnosis and treatment.
11:20		PET-MR: Added Value for the Clinic in Oncologic Imaging View Presentation Video Hersh Chandarana Keywords: Body: Body, Cross-organ: Cancer This talk will review synergy between PET and MRI in oncologic imaging, and discuss different options for acquiring this data with focus on integrated PET-MRI scanner. We will briefly discuss protocol optimization and some of the benefits and challenges of PET-MR when compared to PET-CT. Subsequently, we will review current literature and highlight role of PET-MR imaging in evaluation of number of abdominopelvic malignancies such as lymphoma, colorectal malignancy, GYN malignancies, and prostate cancer. We will highlight some novel and potential applications for PET-MRI in oncology.