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ISMRM Workshop on

Neurofluids:

Anatomy, Physiology & Imaging

21-24 September 2022

Sapienza University of Rome, Rome, Italy

Preliminary Program

Registration & Setup - Wednesday, 21 September 2022

Registration & Speaker Upload Available

Opening Remarks (No CME Available)

Nivedita Agarwal, M.D.
I.R.C.C.S. Eugenio Medea
Bosisio Parini, Lecco, Italy

Neurofluids: What's All the Buzz About?

Nivedita Agarwal, M.D.
I.R.C.C.S. Eugenio Medea
Bosisio Parini, Lecco, Italy

How I Stumbled into Neurofluids

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

Marijan Klarica, M.D., Ph.D.
University of Zagreb
Zagreb, Croatia

Costantino Iadecola, M.D.
Weill Cornell Medicine
New York, NY, USA

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

Welcome Reception

Day 1 - Thursday, 22 September 2022 -- Basic Anatomy & Physiology of Neurofluids

Registration & Speaker Upload Available

Session 1: Cerebrovascular Anatomy & Physiology of Neurofluids

Moderators: Nivedita Agarwal, M.D. & T.B.A.

Anatomy & Physiology of Blood Vessels

Costantino Iadecola, M.D.
Weill Cornell Medicine
New York, NY, USA

Anatomy & Physiology of Meningeal Lymphatics

Sung-Hong Park, Ph.D.
Korea Advanced Institute of Science & Technology
Daejeon, South Korea

Anatomy & Physiology of the Interstitial Fluid & Cerebrospinal Fluids

Marijan Klarica, M.D., Ph.D.
University of Zagreb
Zagreb, Croatia

Break & Speaker Upload Available

Differences Between Animal & Human Anatomy & Physiology

Swati Rane Levendovszky, Ph.D.
University of Washington
Seattle, WA, USA

Neurofluids: The Monro-Kellie Doctrine Assessed by MRI

Noam Alperin, Ph.D.
University of Miami
Miami, FL, USA

Post-it Session with Attendees: What We Know, What We Are Assuming Without Scientific Confirmation & What is Still in the Dark

Costantino Iadecola, M.D., Sung-Hong Park, Ph.D., Marijan Klarica, M.D., Ph.D., Swati Rane Levendovszky, Ph.D.

Scientific Sesssions-Power Pitches

Posterior Fossa Decompression Surgery Increases in CSF Stroke Volume in Pediatric Patients with Chiari Malformation

John Oshinski, Ph.D.
Emory University
Atlanta, GA, USA

Human Cerebral Fluid Concentrations Measured by Wearable fNIRS Technique Support the Munro–Kellie Doctrine

Teemu Myllylä, Dr. Sc., Associate Professor
University of Oulu
Oulu, Finland

CSF Dynamics & Intracranial Compliance Changes in Patients with Chronic Communicating Hydrocephalus According to Phase-Contrast MRI Data

Alexander Khe, Ph.D.
Lavrentyev Institute of Hydrodynamics
Novosibirsk, Russian Federation

The Potential of Ultra-High Resolution T2-Weighted TSE Acquired at 7T to Assess Structures of the Glymphatic System

Hendrik Mattern, Ph.D.
Otto-von-Guericke University
Magdeburg, Germany

Anatomy & Physiology of Interstitial & Cerebrospinal Fluid

Mika Kaakinen, Ph.D.
University of Oulu
Oulu, Finland

Lunch & Speaker Upload Available

Session 2: Macro- & Microstructural Properties of the Brain Parenchyma

Moderators: T.B.A.

Brain Parenchyma/Interstitium Composition, Extracellular Matrix

Gregory Bix, M.D., Ph.D., FAHA
Tulane University
New Orleans, LA, USA

What Are Perivascular Spaces?: A Neuroanatomist Perspective

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

Perivascular Spaces in Clinical MRI

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

Break & Speaker Upload Available

Advanced Imaging of PVS/Segmentation of PVS

Lydiane Hirschler, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

Mathematical Modelling of Brain Fluid Dynamics

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

Post-it Session with Attendees

Scientific Sesssions-Power Pitches

4D Flow MRI for the Study of Cerebrovascular Aging in a Large Cohort of Cognitively Normal Older Adults

Anthony Peret, M.D.
University of Wisconsin-Madison
Madison, USA

Tracking Interstitial Fluid Flow Using Low Molecular Weight Tracers Through Cisternal & Ventricular Injections in a Large Animal Model

Jun Hua, Ph.D.
Johns Hopkins School of Medicine
Baltimore, MD, USA

Investigation of Intra-Arterial Mannitol-Based Blood Brain Barrier Opening by Non-Invasive Macroscopic Sensing Techniques & Advanced Light- & Electron Microscopy

Mika Kaakinen, Ph.D.
University of Oulu
Oulu, Finland

Robotic Simulator for Human CSF System-Wide Macroscale Solute Transport: Application to Intrathecal Drug Delivery Optimization

Bryn Martin, Ph.D.
Alcyone Therapeutics
Moscow, ID, USA

Observing Clearance Pathway in the Brain Using T2 Component Analysis

Koichi Oshio, M.D., Ph.D.
Juntendo University
Tokyo, Japan

T2 MRI visible Perivascular Spaces in Parkinson`s Disease: Clinical Significance

Lena Meinhold, M.Sc.
University of Zurich
Zurich, Switzerland

Perivascular Cerebrospinal Fluid Flow is the Primary Source of Interstitial Fluid in the Rat Brain

Kristian N. Mortensen, M.Sc.
Hvidovre Hospital, Danish Research Centre for Magnetic Resonance
Hvidovre, Denmark

Multi-Expert System for the Differentiation Between Subjects Affected by Higher-Level Gait Disorder & Matched Controls Applied on Brain MR Images from the VESPR Cohort

Klara Mogensen, M.Sc.
Umeå University
Umeå, Sweden

Adjourn

Day 2 - Friday, 23 September 2022 -- Waste Clearance Pathways

Registration & Speaker Upload Available

Session 3: What Is Brain Waste Made Of? Basic Science Behind Neuronal Metabolism & Neuronal Activity

Moderators: T.B.A.

Basics of Brain Waste with a Special Focus on Amyloid & Tau

Cheryl Hawkes, D.Phil.
Lancaster University
Lancaster, England, UK

The Glymphatic System: Anatomy & Physiology

Yuki Mori, Ph.D.
University of Copenhagen
Copenhagen, Denmark

The Intramural Periarterial Drainage (IPAD) Pathway: Anatomy & Physiology

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

Break & Speaker Upload Available

Alternative Pathways to Glymphatics & IPAD

Erik N. Bakker, Ph.D.
Amsterdam UMC
Amsterdam, The Netherlands

Imaging of BBB Permeability in Neurodegenerative & Small Vessel Diseases

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

Post-it session with attendees: Theories/speculations/ground-truth; what if the Glymphatic Theory was wrong? What if the IPAD did not exist? What is the ground truth as of now? What are the missing links?

Cheryl Hawkes, D.Phil., Yuki Mori, Ph.D., Erik N. Bakker, Ph.D., Joanna M. Wardlaw, M.D., FRCP, FMedSci

Scientific Sesssions- Power Pitches

Effects of Impaired Meningeal Lymphatic Drainage on Cognitive Function in Patients with Mild Cognitive Impairment: A Dynamic Contrast-Enhanced MRI Study

Mina Park, M.D., Ph.D.
Yonsei University, Gangnam Severance Hospital
Seoul, South Korea

Imaging D-Glucose in Cerebrospinal Fluid of Alzheimer’s Disease Using Dynamic Glucose Enhanced MRI

Charith Perera, M.Sc.
University College London
London, England, UK

Dynamic Glucose-Enhanced MRI Assesses CSF Transport in Aging Brain

Zilin Chen, M. Phil.
City University of Hong Kong
Hong Kong, China

Hyperparameter & Architecture Optimization of Deep Neural Network to Estimate the Choroid Plexus Volume in Multiple Sclerosis

Valentina Visani, M.Sc.
University of Padova
Padova, Italy

Choroid Plexus Manual Segmentation: Can We Avoid Contrast-Agent in T1-W Images?

Valentina Visani, M.Sc.
University of Padova
Padova, Italy

Changes of Intracranial & Spinal CSF & Venous Flow From Childhood to Young Adulthood Studied by Real-Time Phase Contrast MRI

Prativa Sahoo, Ph.D.
University Medical Center Göttingen
Göttingen, Germany

Cerebrospinal Fluid Efflux Through Cervical Lymphatic Pathways Is Enhanced by Blood Pressure Lowering

Jari Jukkola, M.Sc.
University of Oulu
Oulu, Finland

The Cervical & Meningeal Lymphatic System as a Potential Pathway for the Transport of Exosomes & Nanoparticles From Peripheral Tissues to the Brain

Héctor M Ramos-Zaldívar, M.D., Ph.D. candidate
Pontificia Universidad Católica de Chile
Santiago, Chile

Rate of Flux of Labelled Blood-Water Across the Blood-Cerebrospinal Fluid-Barrier is Significantly Affected by Anaesthetic Regimen.

Shereen Nizari, Ph.D.
University College London
London, England, UK

Signal Changes at the Cerebrospinal Fluid Area During Visual Stimulation for Functional MRI Study

Geon-Ho Jahng, Ph.D.
Kyung Hee University Hospital at Gangdong
Seoul, Republic of Korea

Lunch & Speaker Upload Available

Session 4: Driving Forces of Brain Clearance

Moderators: T.B.A.

Influence of Cardiac/Respiratory Cycle on Waste Clearance: How Do Breathing & Blood Pressure Alter CNS Fluid Driving Forces?

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

Neuronal Activation & the Relation with Brain Clearance

Thomas Broggini, Ph.D.
Universitätsklinikum Frankfurt am Main
Frankfurt, Germany

Space, Posture, ICP & Glymphatics

Petter Holmlund, Ph.D. & Sara E. Qvarlander, Ph.D.
Umeå University
Umeå, Sweden

Break & Speaker Upload Available

Mathematical Modelling of CSF Mobility

Vartan Kurtcuoglu, Ph.D.
University of Zürich
Zürich, Switzerland

Scientific Session-Power Pitches

Cerebral VLF Arterial & Venous Waves Become Synchronized in NREM Sleep

Johanna Tuunanen, M.Sc.
University of Oulu
Oulu, Finland

Brain Hydrodynamic Drive of BOLD Signal Inverts in Sleep

Tommi Väyrynen , M.Sc.
University of Oulu
Oulu, Finland

High Temporal Resolution Quantitative Contrast-Enhanced MRI for Spatial-temporal Quantification of Cerebrospinal Fluid System Wide Intrathecal Gadolinium Pharmacokinetics in Nonhuman Primates

Stuart Sater, M.Sc.
Alcyone Therapeutics
Moscow, ID, USA

MRI Quantification of Effects of Cranial Nerve Stimulation on Glymphatic Function

Nishant Verma, B.S., M.S.
University of Wisconsin - Madison
Madison, WI, USA

MR-based Computational Fluid Dynamics Simulation of Cerebrospinal Fluid Drug Delivery Pharmacokinetics in Nonhuman Primates

Mohammadreza Kahni, Ph.D.
Alcyone Therapeutics
Moscow, Idaho, USA

Diurnal Changes in Cerebrovascular Dynamics Measured from 4D-Flow

Anthony Peret, M.D.
University of Wisconsin-Madison
Madison, WI, USA

Effect of Respiration & Subarachnoid Space Obstruction on Cerebrospinal Fluid Flow

Joel Berliner, Ph.D.
Macquarie University
Macquarie, NSW, Australia

Investigating Effects of Sleep Deprivation on Glymphatic Transport Using Intravoxel Incoherent Motion MRI

Swati D. Rane Levendovszky, Ph.D.
University of Washington School of Medicine
Seattle, WA, USA

Phase-Based Amplified MRI Reveals Impaired CSF Motion Dynamics in Patients With Chiari Malformation

Moss Zhao, Ph.D.
Stanford University
Stanford, CA, USA

Neurovascular Pulsations Are Increased in Alzheimer’s Disease

Vesa Korhonen, Ph.D.
University of Oulu
Oulu, Finland

Post-It Session With Attendees: How Much Do Our Assumptions Influence Our Results

Lynne E. Bilston, Ph.D., Thomas Broggini, Ph.D., Petter Holmlund, Ph.D., Sara E. Qvarlander, Ph.D., & Vartan Kurtcuoglu, Ph.D.

Social Event

Day 3 - Saturday, 24 September 2022 -- Imaging Methods

Registration & Speaker Upload Available

Session 5: Magnetic Resonance-Based Imaging Techniques

Moderators: T.B.A.

Diffusion-Based Imaging

Carlo Pierpaoli, M.D., Ph.D.
National Institutes of Health
Bethesda, MD, USA

Arterial Spin Labeling MRI (& Other Perfusion Techniques)

Matthias J.P. van Osch, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

Resting State of fMRI & White Matter Connectivity

T.B.A.

Break & Speaker Upload Available

Intravenous Gadolinium-Based Imaging

Shinji Naganawa, M.D., Ph.D.
Nagoya University Graduate School of Medicine
Nagoya, Japan

Intrathecal Gadolinium-Based Imaging

Geir Andre Ringstad, M.D.
Oslo University Hospital
Oslo, Norway

Panel Discussion: Opportunities & Challenges of MRI for Brain Clearance Imaging

Session 5 Speakers

Scientific Session-Power Pitches

Quantitative CSF & Brain Motion: Initial Studies on Next Generation 7T Scanner With High Performance Gradients & 128 Channel Receiver

David Feinberg, M.D., Ph.D.
University of California, Berkeley
Bodega Bay, CA, USA

Measuring CSF Net Flow Velocity in the Human Subarachnoid Space With 7T MRI

Lotte van der Voort, M.Sc
University Medical Center Utrecht
Eindhoven, The Netherlands

4D Whole-Brain CSF Flowmetry: Slow Flow Dynamics in Ventricles & Subarachnoid Space

Zijing Dong, Ph.D.
Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, MA, USA

Concurrent Measurement of Perfusion Parameters Related to Small Blood & Lymphatic Vessels in the Human Brain

Jun Hua, Ph.D.
Johns Hopkins School of Medicine
Baltimore, MD, USA

Comparison of Pulsed Gradient Spin-Echo (PGSE) & Stimulated Echo (STE) Sequences for Measuring Creeping Flows – A Phantom Study.

Martin Kozar, M.Phys.
University of Manchester
Manchester, England, UK

Multiplied, Added, Subtracted &/or Divided Inversion Recovery (MASDIR): Technical Considerations for Optimal Clinical Implementation

Letizia Losa, M.Sc.
IRCCS E. Medea - Associazione “La Nostra Famiglia”
Bosisio Parini, Italy

Clinical Implementation of Multiplied, Added, Subtracted &/or Divided (MASDIR) Sequences To Evaluate White Matter Hyperintensities

Nivedita Agarwal, M.D.
I.R.C.C.S. Eugenio Medea
Bosisio Parini, Italy

Three-Dimensional Black-Blood T1 Mapping: Sequence Design & Initial Experience

Yuhui Nie, B.A.
Guangzhou Medical University
Guangzhou, China

Concurrent Measurement of Perfusion Parameters Related to Small Blood & Lymphatic Vessels in the Human Brain

Di Cao, B.Sc. (Ph.D. candidate)
Johns Hopkins University
Baltimore, MD, USA

Investigating Changes in Blood-Cerebrospinal Fluid Barrier Function in a Rat Model of Chronic Hypertension Using Multi-TI ASL MRI

Charith Perera, M.Sc.
University College London
London, England, UK

Low B-Value Diffusion Tensor Imaging (Low-B DTI) for Investigating CSF Motion

Yoshitaka Bito, Ph.D.
FUJIFILM Healthcare Corporation
Chiba, Japan

Lunch & Speaker Upload Available

Session 6: Clinical Applications

Moderators: T.B.A.

Clinical Diseases: CAA-Related Abnormalities/Neurodegenerative Diseases/ARIA

Steven M. Greenberg, M.D., Ph.D.
Massachusetts General Hospital
Boston, MA, USA

CSF Egress Pathways in Aging & Alzheimer using PET

Mony de Leon, Ph.D.
New York University Medical Center
New York, NY, USA

The Eyes as the Window to Brain Clearance

Katerina Deike-Hofmann, M.D.
Universitätsklinikum Bonn
Bonn, Germany

Break

Sleep: Imaging Findings on Neurofluids

Laura Lewis, Ph.D.
Boston University
Boston, MA, USA

Panel Discussion/Meet the Authors

Session 7: Pharmacological Interventions & Neurofluids

Moderators: T.B.A.

Pharmacological Challenges, Ultrasound & Treatment Options (Acetazolamide, CO2, Caffeine)

Jack A. Wells, Ph.D.
University College London
London, England, UK

In Silico and In Vitro Trials for Prediction of CSF Pharmacokinetics: Bridging the Gap from Physics to Biology

Bryn A. Martin, Ph.D.
Alcyone Therapeutics, Inc.
Moscow, ID, USA

Awards

Adjournment

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