ISMRM Workshops: Learn, Share Research & Network

ISMRM Workshop on

Neurofluids:

Anatomy, Physiology & Imaging

21-24 September 2022

Sapienza University of Rome, Rome, Italy

Thank you for a great workshop!

Presentation recordings coming soon.

Organizers

Co-Chairs:
Nivedita Agarwal, M.D.
Olivier Balédent, Ph.D.

Supporters & Declarations

Overview & Program

Workshop Overview

Although the first description of the anatomy of brain lymphatics dates back 250 years, it is only in the past decade or so that there is groundbreaking evidence from both animal and human studies proving the existence of a brain clearance system via CSF and ISF flow. This shows that fundamental elements of the brain anatomy and physiology have been neglected for too long and that there is an urgent need for in vivo imaging technology to monitor brain clearance. It is only in the recent past that some elements of brain clearance are being imaged using cutting-edge MR techniques such as contrast-enhanced MRI, diffusion tensor imaging, perfusion-weighted imaging, MR elastography, and flow studies to name a few. There is tremendous excitement in this field and such discoveries have the potential to revolutionize our understanding of most neurodegenerative and neuroinflammatory diseases.The workshop will have a strong multi-disciplinary character and attendees will get ample chances to share their knowledge, speak to experts and peers, and develop joint projects. We will also suggest protocols, spend time using selected software, and invite proffered full papers on this field.

Target Audience:

This workshop is designed to attract scientists at all levels of career and experience who are keen on deepening their current understanding of the anatomy, physiology, and MR techniques available for imaging meningeal lymphatics and brain waste clearance pathways.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe the anatomy and physiology of meningeal lymphatic pathways;
  • Describe the different theories on brain clearance both regarding common elements as well as still-disputed components;
  • Describe current imaging methods to probe the brain clearance system;
  • Describe how diseases affect brain clearance as well as MRI of brain clearance;
  • Identify gaps in our current MRI arsenal for monitoring brain clearance; and
  • Identify current barriers for widespread dissemination of brain clearance MRI.

Program

Abstracts & syllabi linked below are available to registered attendees only.

  • Username: Your Member ID Number
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Registration & Setup - Wednesday, 21 September 2022

Registration & Speaker Upload Available

Opening Remarks

Nivedita Agarwal, M.D.
Prof. Tito Marci
Prof. Alessandro Bozzao

Nivedita Agarwal, M.D.
Istituto di Ricovero e Cura a Carattere Scientifico Eugenio Medea
Bosisio Parini, Italy

How I Stumbled into Neurofluids

Joanna M. Wardlaw, M.D., FRCP, FMedSci
Marijan Klarica, M.D., Ph.D.
Costantino Iadecola, M.D.
Roxana O. Carare, M.D., Ph.D.

Welcome Reception

Day 1 - Thursday, 22 September 2022 - Basic Anatomy & Physiology of Neurofluids

Registration & Speaker Upload Available

Session 1: Cerebrovascular Anatomy & Physiology of Neurofluids

Moderators: Erik Bakker, Ph.D., & Kannie WY Chan, Ph.D.

Costantino Iadecola, M.D.
Weill Cornell Medicine
New York, NY, USA

Anatomy & Physiology of Meningeal Lymphatics

Sung-Hong Park, Ph.D.
Korea Advanced Institute of Science & Technology
Daejeon, South Korea

Anatomy & Physiology of the Interstitial Fluid & Cerebrospinal Fluids

Marijan Klarica, M.D., Ph.D.
University of Zagreb
Zagreb, Croatia

Break & Speaker Upload Available

Differences Between Animal & Human Anatomy & Physiology

Swati Rane Levendovszky, Ph.D.
University of Washington
Seattle, WA, USA

Neurofluids: The Monro-Kellie Doctrine Assessed by MRI

Noam Alperin, Ph.D.
University of Miami
Miami, FL, USA

Post-it Session with Attendees: What We Know, What We Are Assuming Without Scientific Confirmation & What is Still in the Dark

Costantino Iadecola, M.D.,
Sung-Hong Park, Ph.D.,
Marijan Klarica, M.D., Ph.D.,
Swati Rane Levendovszky, Ph.D.

Scientific Sessions - Power Pitches

Teemu Myllylä, Dr. Sc., Associate Professor
University of Oulu
Oulu, Finland

Marijan Klarica, M.D., Ph.D.
University of Zagreb, School of Medicine
Zagreb, Croatia

Lunch & Speaker Upload Available

Session 2: Macro & Micro Structural Properties of the Brain Parenchyma

Moderators: Nivedita Agarwal, M.D. & Marco Castellaro, Ph.D.

The Perivascular Extracellular Matrix & its Cellular Receptors as Regulators of Injury & Disease

Gregory Bix, M.D., Ph.D., FAHA
Tulane University
New Orleans, LA, USA

What Are Perivascular Spaces?: A Neuroanatomist Perspective

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

Perivascular Spaces in Clinical MRI

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

Break & Speaker Upload Available

Advanced Imaging of PVS/Segmentation of PVS

Lydiane Hirschler, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

Post-it Session with Attendees

Scientific Sessions - Power Pitches

Koichi Oshio, M.D., Ph.D.
Juntendo University
Tokyo, Japan

Lena Meinhold, M.Sc.
University of Zurich
Zurich, Switzerland

Kristian N. Mortensen, M.Sc.
Hvidovre Hospital, Danish Research Centre for Magnetic Resonance
Hvidovre, Denmark

Adjourn

Day 2 - Friday, 23 September 2022 - Waste Clearance Pathways

Registration & Speaker Upload Available

Session 3: What Is Brain Waste Made Of? Basic Science Behind Neuronal Metabolism & Neuronal Activity

Moderators: Hedok Lee, Ph.D. & Ruth O'Gorman Tuura, Ph.D.

Basics of Brain Waste with a Special Focus on Amyloid & Tau

Cheryl Hawkes, D.Phil.
Lancaster University
Lancaster, England, UK

The Glymphatic System: Anatomy & Physiology

Yuki Mori, Ph.D.
University of Copenhagen
Copenhagen, Denmark

The Intramural Periarterial Drainage Pathway (IPAD): Anatomy & Physiology

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

Break & Speaker Upload Available

Alternative Pathways to Glymphatics & IPAD

Erik N. Bakker, Ph.D.
Amsterdam Medical Center
Amsterdam, The Netherlands

Imaging of BBB Permeability in Neurodegenerative & Small Vessel Diseases

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

Post-It Session With Attendees: Theories/Speculations/Ground-Truth; What if the Glymphatic Theory Was Wrong? What if the IPAD Did Not Exist? What Is the Ground Truth As of Now? What Are the Missing Links?

Cheryl Hawkes, D.Phil.
Yuki Mori, Ph.D.
Erik N. Bakker, Ph.D.
Joanna M. Wardlaw, M.D., FRCP, FMedSci

Scientific Sessions - Power Pitches

Zilin Chen, M. Phil.
City University of Hong Kong
Hong Kong, China

Valentina Visani, M.Sc.
University of Padova
Padova, Italy

Héctor M Ramos-Zaldívar, M.D., Ph.D. Candidate
Pontificia Universidad Católica de Chile
Santiago, Chile

Geon-Ho Jahng, Ph.D.
Kyung Hee University Hospital at Gangdong
Seoul, Republic of Korea

Lunch & Speaker Upload Available

Session 4: Driving Forces of Brain Clearance

Moderators: Jaco Zwanenburg, Ph.D. & Mina Park, M.D., Ph.D.

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

Vasomotor Waves & the Potential Relation with Brain Clearance

Thomas Broggini, Ph.D.
Universitätsklinikum Frankfurt am Main
Frankfurt, Germany

Space, Posture, ICP & Glymphatics

Petter Holmlund, Ph.D. &
Sara E. Qvarlander, Ph.D.
Umeå University
Umeå, Sweden

Break & Speaker Upload Available

Vartan Kurtcuoglu, Ph.D.
University of Zürich
Zürich, Switzerland

Scientific Session-Power Pitches

Johanna Tuunanen, M.Sc.
University of Oulu
Oulu, Finland

Tommi Väyrynen, M.Sc.
University of Oulu
Oulu, Finland

Nishant Verma, B.S., M.S.
University of Wisconsin - Madison
Madison, WI, USA

Leonardo Rivera-Rivera, Ph.D.
University of Wisconsin-Madison
Madison, WI, USA

Joel Berliner, Ph.D.
Macquarie University
Macquarie, NSW, Australia

Swati D. Rane Levendovszky, Ph.D.
University of Washington School of Medicine
Seattle, WA, USA

Vesa Korhonen, Ph.D.
University of Oulu
Oulu, Finland

Post-It Session with Attendees: How Much Do Our Assumptions Influence Our Results?

Lynne E. Bilston, Ph.D.
Thomas Broggini, Ph.D.
Petter Holmlund, Ph.D.
Sara E. Qvarlander, Ph.D.
Vartan Kurtcuoglu, Ph.D.

Social Event

Day 3 - Saturday, 24 September 2022 -- Imaging Methods

Registration & Speaker Upload Available

Session 5: Magnetic Resonance-Based Imaging Techniques

Moderators: Moss Zhao D. Phil., Karin Markenroth Bloch, Ph.D.

Diffusion-Based Imaging

Carlo Pierpaoli, M.D., Ph.D.
National Institutes of Health
Bethesda, MD, USA

Matthias J.P. van Osch, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

Break & Speaker Upload Available

Shinji Naganawa, M.D., Ph.D.
Nagoya University Graduate School of Medicine
Nagoya, Japan

Geir Andre Ringstad, M.D.
Oslo University Hospital
Oslo, Norway

Panel Discussion: Opportunities & Challenges of MRI for Brain Clearance Imaging

Carlo Pierpaoli, M.D., Ph.D.
Matthias J.P. van Osch, Ph.D.
Shinji Naganawa, M.D., Ph.D.
Geir Andre Ringstad, M.D.

Scientific Session-Power Pitches

Lotte van der Voort, M.Sc
University Medical Center Utrecht
Eindhoven, The Netherlands

Zijing Dong, Ph.D.
Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, MA, USA

Di Cao, B.Sc. (Ph.D. candidate)
Johns HopkinsUniversity
Baltimore, MD, USA

Letizia Losa, M.Sc.
Istituto di Ricovero e Cura a Carattere Scientifico Eugenio Medea
Bosisio Parini, Italy

Nivedita Agarwal, M.D.
Istituto di Ricovero e Cura a Carattere Scientifico Eugenio Medea
Bosisio Parini, Italy

Yuhui Nie, B.A.
Guangzhou Medical University
Guangzhou, China

Yoshitaka Bito, Ph.D.
FUJIFILM Healthcare Corporation
Chiba, Japan

Lunch & Speaker Upload Available

Session 6: Clinical Applications

Moderators: Marieke Wermer, M.D., Ph.D. & Yu-Chien Wu, M.D., Ph.D.

Clinical Diseases: CAA-Related Abnormalities/Neurodegenerative Diseases/ARIA

Steven M. Greenberg, M.D., Ph.D.
Massachusetts General Hospital
Boston, MA, USA

CSF Egress Pathways in Aging & Alzheimer Using PET

Mony de Leon, Ph.D.
Weill Cornell Medicine
New York, NY, USA

The Eyes as the Window to Brain Clearance

Katerina Deike-Hofmann, M.D.
Universitätsklinikum Bonn
Bonn, Germany

Break

Cranio-Spinal Malformations & Neurofluid Dynamic Alterations in the Spine

Marcus Stoodley
Macquarie Medical School
Pymble, NSW, Australia

Sleep: Imaging Findings on Neurofluids

Laura Lewis, Ph.D.
Boston University
Boston, MA, USA

Panel Discussion/Meet the Authors

Session 7: Pharmacological Interventions & Neurofluids

Moderators: Richard Wise, Ph.D. & Leonardo A. Rivera-Rivera, Ph.D.

Investigating Blood-Cerebrospinal Fluid Barrier Function Using Non-Invasive MRI

Jack A. Wells, Ph.D.
University College London
London, England, UK

In Silico & In Vitro Trials for Prediction of CSF Pharmacokinetics: Bridging the Gap from Physics to Biology

Bryn A. Martin, Ph.D.
Alcyone Therapeutics, Inc.
Moscow, ID, USA

Awards

Adjournment

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