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ISMRM Workshop on

MRI of Neuromodulation:

Target Engagement, Neural Mechanism & Biomarker Development

17-19 October 2022

Ruth Kirschstein Auditorium, NIH Building 45
Bethesda, MD, USA

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Organizers

Co-Chairs:
Danny JJ Wang, Ph.D.
Yihong Yang, Ph.D.

Supporters & Declarations

Faculty declarations will be available approx. 2 weeks before workshop start.

Funding for the ISMRM workshop on MRI of Neuromodulation was made possible (in part) from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Overview & Program

Workshop Overview

During recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS), as well as alternative methods using optical and ultrasonic modulations, have become an important means to study how complex neural circuits interact in the brain, to manipulate human cognition, and to treat brain disorders. Magnetic resonance imaging (MRI) can now be performed either concurrently with or pre- and post-these neuromodulation techniques to visualize their effects on the human brain, to understand the neurophysiological mechanism, and to improve their efficacy. The proposed workshop will bring together a diverse group of scientists and clinicians as well as industry partners who are interested in developing and applying advanced MRI techniques to visualize, understand, and quantify neuromodulation effects on the human brain. This workshop will be the first of its kind on the topic of MRI in neuromodulation in ISMRM history and will integrate presentations with ample discussion periods covering advances in various MRI techniques for neuromodulation (electromagnetic field mapping, functional connectivity, arterial spin labeled perfusion and permeability, temperature and acoustic radiation force imaging, etc.), preclinical animal models and cellular-level mechanisms of neuromodulation, and safety issues related to MRI with neuromodulation devices. Existing and emerging clinical applications for MRI in neuromodulation and biomarker development will be discussed between academic and industry partners.

Target Audience:

MRI scientists interested in developing novel methods for in-vivo imaging of neuromodulation effects on human brain using MRI; neuroscientists, neurologists, psychiatrists, and neurosurgeons interested in the application of in-vivo imaging of neuromodulation effects on human brain using MRI; and manufacturers of MRI and/or neuromodulation devices interested in latest advances of MRI in neuromodulation.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Explain the state-of-the-art and latest developments of concurrent MRI and neuromodulation techniques including tDCS, TMS, DBS, and emerging optical and ultrasonic modulations;
  • Define the biophysical and neurophysiological parameters that can be measured by MRI of neuromodulation;
  • Recognize the potentials and challenges of in-vivo MRI mapping of neuromodulation; and
  • Identify the suitable clinical applications and associated barriers need to be overcome for the translation ofMRI in neuromodulation.

Preliminary Program

Note: all times below are shown first in EDT followed by the equivalent in your local time zone.

Registration & Setup - Sunday, 16 October 2022

Registration & Speaker Upload Available

Day 1 - Monday, 17 October 2022

Registration & Speaker Upload Available
Breakfast

Welcome Address & Remarks

Organizing Committee & Local Hosts

Session 1: MRI for Neurophysiological Mechanism of Neuromodulation

Moderators: Yihong Yang, Ph.D. & T.B.A.

Toward a Better Understanding of fMRI Signals Using Neuromodulation & Recording

Yen-Yu Ian Shih, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC, USA

Cellular Mechanisms of TMS

Hanbing Lu, Ph.D.
National Institute on Drug Abuse, NIH
Baltimore, MD, USA

Mechanism of Transcranial Focused US

Jan Kubanek, Ph.D.
University of Utah
Salt Lake City, UT, USA

Break & Speaker Upload Available

Keynote Speaker

Sarah Lisanby, M.D.
National Institute of Mental Health-NIH
Bethsesda, MD, USA

Session 2: MRI in TMS

Moderators: Desmond Oathes, Ph.D. & T.B.A.

Concurrent TMS/MRI

Olivier Reynaud, Ph.D.
Fondation Campus Biotech Geneva
Genève, Switzerland

MRI & TMS

Dogu Baran Aydogan, Ph.D.
University of Eastern Finland
Kuopio, Finland

Specialized Hardware for Concurrent TMS/fMRI & TMS/fMRI/EEG, Interactions Between the Systems & Safety

Lucia I. Navarro de Lara, Ph.D.
Harvard Medical School
A.A. Martinos Center For Biomedical Imaging
Charlestown, MA, USA

Proffered Papers - Oral Session

Abstract #1

 

Abstract #2

 

Abstract #3

 

Group Photo
Lunch & Speaker Upload Available

Session 3: Emerging MRI in Optical & Ultrasonic Neuromodulation (rs-fMRI & Temperature & Acoustic Radiation Force Imaging of Optical & US Modulation)

Moderators: Bastien Guerin, Ph.D. & T.B.A.

MRI-Guided Transcranial Focused US in Addiction & Pain

Wynn Legon, Ph.D.
Fralin Biomedical Research Institute at VTC
Roanoke, VA, USA

MRI of Near-Infrared Optical Modulation

Jacek P. Dmochowski, Ph.D.
The City College of New York
New York, NY, USA

MR-Based Verification of Transcranial Ultrasound Simulation Targeting with MR-ARFI &/or MR-Bone Imaging-Based Simulation

Kim Butts Pauly, Ph.D.
Stanford University
Stanford, CA, USA

Proffered Papers - Oral Session

Abstract #4

 

Abstract #5

 

Abstract #6

 

Break & Speaker Upload Available

Session 4: Power Pitch & Poster Session (No CME Available)

Moderators: Dogu Baran Aydogen, Ph.D. & T.B.A.

PP Topic #1 T.B.A.

T.B.A.

 

PP Topic #2 T.B.A.

T.B.A.

 

PP Topic #3 T.B.A.

T.B.A.

 

PP Topic #4 T.B.A.

T.B.A.

 

Adjourn

Day 2 - Tuesday, 18 October 2022

Registration & Speaker Upload Available
Breakfast

Session 5: MRI in Transcranial Electrical Stimulation (TES)

Moderators: Silvina G. Horovitz, Ph.D. & T.B.A.

MR Current Density Imaging (MRCDI)

Axel Thielscher, Ph.D.
MPI for Biological Cybernetics
Tubingen, Germany

Current Mapping for tDCS/tACS

Rosalind Sadleir, Ph.D.
Arizona State University
Tempe, AZ, USA

Magnetic Field Mapping, rs-fMRI & ASL for tDCS

Danny JJ. Wang, Ph.D., M.Sc.
University of Southern California
Los Angeles, CA, USA

How to Integrate tES with fMRI: Quality Standards, Challenges & Hopes

Hamed Ekhtiari, M.D., Ph.D.
Laureate Institute for Brain Research
Tulsa, OK, USA

Proffered Papers - Oral Session

Abstract #7

 

Abstract #8

 

Abstract #9

 

Break & Speaker Upload Available

Session 6: MRI in DBS

Moderators: Sayim Gokyar, Ph.D. & T.B.A.

Concurrent MRI & DBS (Technical Basic, Safety for Real Time Active DBS)

Alexandre Boutet,
University of Toronto
Toronto, ON, CA

Concurrent MRI & DBS (Technical Basic, Safety for Real Time Active DBS)

Pallab K. Bhattacharyya, Ph.D.
Cleveland Clinic Foundation
Cleveland, OH, USA

DBS Targets for Neurologic Disorders (Epilepsy, Real-Time)

Erik H. Middlebrooks, M.D.
Mayo Clinic
Jacksonville, FL, USA

Proffered Papers - Oral Session

Abstract # 10

 

Abstract #11

 

Abstract #12

 

Lunch & Speaker Upload Available

Session 7: Modeling and Safety Issues of MRI in Neuromodulation

Moderators: Lucia I. Navarro de Lara, Ph.D. & T.B.A.

ROAST- An Open-Source Platform for Modeling Transcranial Electrical Stimulation & its Validation

Yu (Andy) Huang, Ph.D.
Memorial Sloan Kettering Cancer Center
New York, NY, USA

Modeling of TMS

Zhi-De Deng , Ph.D.
National Institute of Mental Health
Bethsesda, MD, USA

SimNIMS

Oula Puonti,
DRCMR & Technical University of Denmark
Kongens Lyngby, Denmark

Safety of MRI in Neuromodulation

Frank G. Shellock, Ph.D., FACR,FISMRM, FACC
University of Southern California
Los Angeles, CA, USA

Proffered Papers - Oral Session

Abstract #13

 

Abstract #14

 

Break & Speaker Upload Available

Session 8: Power Pitch & Poster Session (No CME Available)

Moderators: Olivier Reynaud, Ph.D. & T.B.A.

PP Topic #1 T.B.A.

T.B.A.

 

PP Topic #2 T.B.A.

T.B.A.

 

PP Topic #3 T.B.A.

T.B.A.

 

PP Topic #4 T.B.A.

T.B.A.

 

Poster Sesssion (No CME Available)

Adjourn

Day 3 - Wednesday, 19 October 2022

Registration & Speaker Upload Available
Breakfast

Session 9: Applications of MRI Neuromodulation in Neurologic Disorders

Moderators: Hamed Ekhtiari, M.D., Ph.D. & T.B.A.

Combining Neuroimaging, Computational Modeling & Machine Learning to Predict tDCS Treatment Response & Customize Dosing

Adam Woods, Ph.D.
University of Florida
Gainesville, FL, USA

TMS & fMRI in Movement Disorders

Silvina G. Horovitz, Ph.D.
National Institute of Neurological Disorder
Bethsesda, MD, USA

MRI Guided fUS

Li-Min Chen, Ph.D.
Vanderbilt University Medical Center
Nashville, TN, USA

Proffered Papers - Oral Session

Abstract #15

 

Abstract #16

 

Abstract#17

 

Break & Speaker Upload Available

Session 10: Applications of MRI Neuromodulation in Psychiatric Disorders

Moderators: Yihong Yang, Ph.D. & Danny JJ Wang, Ph.D.

TMS/fMRi in Depression & Stress

Desmond Oathes, Ph.D.
University of Pennsylvania Perelman School of Medicine
Philadelphia, PA, USA

Toward Connectomic Deep Brain Stimulation in OCD

Andreas Horn, Ph.D.
Brigham & Women's Hospital
Boston, MA, USA

Concurrent MRI & TMS of Drug Addiction

Yihong Yang, Ph.D.
National Institue on Drug Abuse (NIH)
Baltimore, MD, USA

Session 11: Panel Discussion MRI Biomarker Development in Neuromodulation (Academic-Industry Partnership for Biomarker Discovery & Development) (No CME Available)

Future Directions & Open Discussion

Poster Awards Ceremony & Closing Remarks

Adjournment & Box Lunches

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