ISMRM Workshops: Learn, Share Research & Network

ISMRM Workshop on

Neurofluids:

Anatomy, Physiology & Imaging

21-24 September 2022

Rome, Italy

Call for Abstracts & Stipend Applications

Coming Soon

Deadline:

Organizers

Co-Chairs:
Nivedita Agarwal, M.D.
Olivier Balédent, Ph.D.

Registration & Travel

Registration Coming Soon

Travel Information Coming Soon

Supporters & Declarations

Faculty declarations will be available approx. 2 weeks before workshop start.

Overview & Program

Workshop Overview

Although the first description of the anatomy of brain lymphatics dates back 250 years, it is only in the past decade or so that there is groundbreaking evidence from both animal and human studies proving the existence of a brain clearance system via CSF and ISF flow. This shows that fundamental elements of the brain anatomy and physiology have been neglected for too long and that there is an urgent need for in vivo imaging technology to monitor brain clearance. It is only in the recent past that some elements of brain clearance are being imaged using cutting-edge MR techniques such as contrast-enhanced MRI, diffusion tensor imaging, perfusion-weighted imaging, MR elastography, and flow studies to name a few. There is tremendous excitement in this field and such discoveries have the potential to revolutionize our understanding of most neurodegenerative and neuroinflammatory diseases.The workshop will have a strong multi-disciplinary character and attendees will get ample chances to share their knowledge, speak to experts and peers, and develop joint projects. We will also suggest protocols, spend time using selected software, and invite proffered full papers on this field.

Target Audience:

This workshop is designed to attract scientists at all levels of career and experience who are keen on deepening their current understanding of the anatomy, physiology, and MR techniques available for imaging meningeal lymphatics and brain waste clearance pathways.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe the anatomy and physiology of meningeal lymphatic pathways;
  • Describe the different theories on brain clearance both regarding common elements as well as still-disputed components;
  • Describe current imaging methods to probe the brain clearance system;
  • Describe how diseases affect brain clearance as well as MRI of brain clearance;
  • Identify gaps in our current MRI arsenal for monitoring brain clearance; and
  • Identify current barriers for widespread dissemination of brain clearance MRI.

Preliminary Program

Registration & Setup - Wednesday, 21 September 2022

16:00 CEST

Registration & Speaker Upload Available

18:00 CEST

Opening Remarks

18:15 CEST

Neurofluids: What's All the Buzz About?

Nivedita Agarwal, M.D.
I.R.C.C.S. Eugenio Medea
Bosisio Parini, Lecco, Italy

18:45 CEST

How I Stumbled into Neurofluids

T.B.A.

19:30 CEST

Welcome Reception

Day 1 - Thursday, 22 September 2022 -- Basic Anatomy & Physiology of Neurofluids

07:30 CEST

Registration & Speaker Upload Available

Session 1: Cerebrovascular Anatomy & Physiology

Moderators: TBD

08:30 CEST

Anatomy & Physiology of Blood Vessels

Costantino Iadecola, M.D.
Weill Cornell Medicine
New York, NY, USA

09:00 CEST

Anatomy & Physiology of Meningeal Lymphatics

Sung-Hong Park, Ph.D.
Korea Advanced Institute of Science & Technology
Daejeon, South Korea

09:30 CEST

Anatomy & Physiology of the Interstitial Fluid & Cerebrospinal Fluids

Marijan Klarica, M.D., Ph.D.
University of Zagreb
Zagreb, Croatia

10:00 CEST

Differences Between Animal & Human Anatomy & Physiology

Swati Rane Levendovszky, Ph.D.
University of Washington
Seattle, WA, USA

10:30 CEST

Break & Speaker Upload Available

11:00 CEST

Neurofluids: The Monro-Kellie Doctrine Assessed by MRI

Noam Alperin, Ph.D.
University of Miam
Miami, FL, USA

11:30 CEST

Panel Discussion: What we know, what we are assuming without scientific confirmation & what is still in the dark

Facilitators TBD

12:00 CEST

Power Pitch Session

12:30 CEST

Lunch & Speaker Upload Available

Session 2: Macro- & Microstructural Properties of the Brain Parenchyma

Moderators: TBD

14:00 CEST

Brain Parenchyma/Interstitium Composition, Extracellular Matrix

Gregory Bix, M.D., Ph.D., FAHA
Tulane University
New Orleans, LA, USA

14:30 CEST

What Are Perivascular Spaces?: A Neuroanatomist Perspective

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

15:00 CEST

Perivascular Spaces in Clinical MRI

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

15:30 CEST

Break & Speaker Upload Available

16:00 CEST

Advanced Imaging of PVS/Segmentation of PVS

Lydiane Hirschler, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

16:30 CEST

Mathematical Modelling of Brain Fluid Dynamics

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

17:00 CEST

Power Pitch Sesssions

18:00 CEST

Meet the Authors

18:30 CEST

Adjourn

Day 2 - Friday, 23 September 2022 -- Waste Clearance Pathways

07:30 CEST

Registration & Speaker Upload Available

Session 3: What Is Brain Waste Made Of? Basic Science Behind Neuronal Metabolism & Neuronal Activity

Moderators: TBD

08:30 CEST

Basics of Brain Waste with a Special Focus on Amyloid & Tau

Cheryl Hawkes, D.Phil.
Lancaster University
Lancaster, England, UK

09:00 CEST

The Glymphatic System: Anatomy & Physiology

Yuki Mori, Ph.D.
University of Copenhagen
Copenhagen, Denmark

09:30 CEST

The Intramural Periarterial Drainage (IPAD) Pathway: Anatomy & Physiology

Roxana O. Carare, M.D., Ph.D.
University of Southampton
Southampton, England, UK

10:00 CEST

Alternative Pathways to Glymphatics & IPAD

Erik N. Bakker, Ph.D.
Amsterdam UMC
Amsterdam, The Netherlands

10:30 CEST

Break & Speaker Upload Available

11:00 CEST

Clinical Diseases: CAA-Related Abnormalities/Neurodegenerative Diseases/ARIA

Steven M. Greenberg, M.D., Ph.D.
Massachusetts General Hospital
Boston, MA, USA

11:30 CEST

Panel Discussion: Theories/speculations/ground-truth; what if the Glymphatic Theory was wrong? What if the IPAD did not exist? What is the ground truth as of now? What are the missing links?

Facilitators TBD

12:00 CEST

Power Pitch Sesssions

13:00 CEST

Lunch & Speaker Upload Available

Session 4: Driving Forces of Brain Clearance

Moderators: TBD

14:30 CEST

Influence of Cardiac/Respiratory Cycle on Waste Clearance: The MR Elastography View on the Driving Forces

Lynne E. Bilston, Ph.D.
Neuroscience Research Australia & University of New South Wales
Randwick, NSW, Australia

15:00 CEST

Neuronal Activation & the Relation with Brain Clearance

David Kleinfeld, Ph.D.
University of California, San Diego
La Jolla, CA, USA

15:30 CEST

Space, Posture, ICP & Glymphatics

Petter Holmlund, Ph.D. & Sara E. Qvarlander, Ph.D.
Umeå University
Umeå, Sweden

16:00 CEST

Break & Speaker Upload Available

16:30 CEST

Mathematical Modeling of CSF Mobility

Vartan Kurtcuoglu, Ph.D.
University of Zürich
Zürich, Switzerland

17:00 CEST

Power Pitch Sesssions

18:00 CEST

Adjourn

18:30 CEST

Social Event

Day 3 - Saturday, 24 September 2022 -- Imaging Methods

07:30 CEST

Registration & Speaker Upload Available

Session 5: Magnetic Resonance-Based Imaging Techniques

Moderators: TBD

08:30 CEST

Diffusion-Based Imaging

Denis Le Bihan, M.D., Ph.D.
CEA Neurospin
Gif-sur-Yvette, France

09:00 CEST

Arterial Spin Labeling MRI (& Other Perfusion Techniques)

Matthias J.P. van Osch, Ph.D.
Leiden University Medical Center
Leiden, The Netherlands

09:30 CEST

Intrathecal Gadolinium-Based Imaging

Geir Andre Ringstad, M.D.
Oslo University Hospital
Oslo, Norway

10:00 CEST

Intravenous Gadolinium-Based Imaging

Shinji Naganawa, M.D., Ph.D.
Nagoya University Graduate School of Medicine
Nagoya, Japan

10:30 CEST

Break & Speaker Upload Available

11:00 CEST

Imaging of BBB Permeability in Neurodegenerative & Small Vessel Diseases

Joanna M. Wardlaw, M.D., FRCP, FMedSci
University of Edinburgh
Edinburgh, Scotland, UK

11:30 CEST

Panel Discussion: Opportunities & Challenges of MRI for Brain Clearance Imaging

Session 5 Speakers

12:00 CEST

Power Pitch Sesssions

13:00 CEST

Lunch & Speaker Upload Available

Session 6: Clinical Applications

Moderators: TBD

14:30 CEST

Cranio-Spinal Malformations & Neurofluid Dynamic Alterations in the Spine

Rafeeque A. Bhadelia, M.D.
Beth Israel Deconess Medical Center
Boston, MA, USA

15:00 CEST

The Glymphatic System of the Spine: Clinical Relevance?

Marcus A. Stoodley, Ph.D., FRACS
Macquarie University
Sydney, NSW, Australia

15:30 CEST

The Eyes as the Window to Brain Clearance

Katerina Deike-Hofmann, M.D.
Universitätsklinikum Bonn
Bonn, Germany

16:00 CEST

Sleep: Imaging Findings on Neurofluids

Laura Lewis, Ph.D.
Boston University
Boston, MA, USA

16:30 CEST

Panel Discussion/Meet the Authors

17:00 CEST

Break

Session 7: Pharmacological Interventions & Neurofluids

Moderators: TBD

17:30 CEST

Pharmacological Challenges, Ultrasound & Treatment Options (Acetazolamide, CO2, Caffeine)

Jack A. Wells, Ph.D.
University College London
London, England, UK

18:00 CEST

CNS Delivery of Drugs

Ajay Verma, M.D.
University of Southampton
Southampton, England, UK

18:30 CEST

Awards

19:00 CEST

Adjournment

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