BY BLAKE DEWEY
In the early days of 2017, we sat down (virtually, of course) to have a conversation with Moritz Zaiss, Johannes Windschuh and Alexander Radbruch. Our topic was their recent MRM paper, “Downfield-NOE-Suppressed Amide-CEST-MRI at 7 Tesla Provides a Unique Contrast in Human Glioblastoma”. Chemical Exchange Saturation Transfer (CEST) imaging is an indirect imaging technique for the protons of certain metabolites, where saturation is applied off-resonance (with respect to water). Saturated protons are then allowed to exchange with water protons and then imaged using conventional imaging methods. However, frequency selection is not always enough to specifically target a functional group, such as amide groups, which are common in CEST imaging methods, producing a “mixed” contrast. Moritz, Johannes and Alexander, together with others in their group, have been slowly removing confounding effects in an attempt to isolate the measurement of amide proton transfer. In this paper, they continue their efforts by removing the downfield Nuclear Overhauser Effect (NOE), resulting in clinically relevant findings and correlation with gadolinium uptake in patients with glioblastoma.
January Cover Art
True and apparent optogenetic BOLD fMRI signals, by Florian Schmid, Lydia Wachsmuth, Franziska Albers, Miriam Schwalm, Albrecht Stroh and Cornelius Faber.
January Editor’s Picks
Advanced processing and simulation of MRS data using the FID appliance (FID-A)—An open source, MATLAB-based toolkit, by Robin Simpson, Gabriel A. Devenyi, Peter Jezzard, T. Jay Hennessy and Jamie Near.
Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma, by Moritz Zaiss, Johannes Windschuh, Steffen Goerke, Daniel Paech, Jan-Eric Meissner, Sina Burth, Philipp Kickingereder, Wolfgang Wick, Martin Bendszus, Heinz-Peter Schlemmer, Mark E. Ladd, Peter Bachert and Alexander Radbruch.
BY MARK CHIEW
Two days after American Thanksgiving, we had the opportunity to speak with Lia Hocke, Yunjie Tong and Blaise Frederick about their recent MRM paper “Comparison of peripheral near-infrared spectroscopy low-frequency oscillations to other denoising methods in resting state functional MRI with ultrahigh temporal resolution”. Working out of the McLean Hospital, part of Harvard Medical School, they shared their perspective on the mutual information contained in peripheral NIRS (near infrared spectroscopy) and fMRI signals. They also used the word “photoplethysmograph” correctly in a sentence, and left us with a delightful shout-out to statistical rigor.
BY XIN MIAO
Dongwook Lee is currently a PhD student at the Korea Advanced Institute of Science and Technology (KAIST). He works on advanced image reconstruction techniques for dynamic MRI. His paper, selected as the Editor’s Pick for December, is entitled “Acceleration of MR parameter mapping using annihilating filter-based low rank Hankel matrix (ALOHA)”. ALOHA is a novel image reconstruction algorithm with the goal of clear, artifact free images acquired from very fast imaging schemes. For this paper, ALOHA was applied to accelerated MR parameter mapping, but could also be used for dynamic and parallel MRI, and even non-MR applications. We recently invited Dongwook and his supervisor, Dr. Jong Chul Ye, to talk about this paper.