Quiz: Diffusion Modeling and Microstructure Probing, Ianus

1. What is diffusion MRI signal sensitive to?

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2. What are the main assumptions of DTI?

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3. In which range of b-values can DKI better explain the measured data compared to DTI?

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4. Diffusion spectrum imaging (SDI) is based on...

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5. Which of the following statements are true about biophysical models?

A. They aim to model the effect of different tissue properties on the acquired signal to extract metrics which reflect certain tissue features
B. They provide an exact representation of the underlying tissue
C. All models require the same acquisitions
D. There is only one model which can accurately represent the measured data

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6. Which of the following statements are true about models which account for restricted diffusion inside axons?

A. Can provide accurate estimates of axon diameter over the entire physiological range of values
B. Have sensitivity to axon diameter only for values above a certain threshold, depending on the acquisition parameters
C. Tend to overestimate the axon diameter distribution compared to histology
D. B and C

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7. Which of the following statements are true about NODDI?

A. Models separately the effect of fibre orientation distribution and volume fraction
B. Is clinically feasible
C. Provides and exact representation of the underlying tissue microstructure
D. A and B
E. A, B and C

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8. Which of the following statements are true about diffusion imaging in cancer?

A. Biophysical models have been applied only for brain imaging
B. The IVIM model aims to separate the contribution of perfusion and diffusion in tissue.
C. Accounting for restricted diffusion (e.g. RSI, VERDICT) is important in capturing the diffusion properties of tumours
D. A and B
E. B and C

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