Quiz: Hyperpolarized 13C, Vigneron

Which unique ability renders hyperpolarized 13C MRI interesting for biomedical imaging applications? The ability to detect...

the spatial distribution of an injected compound
the cellular uptake of an injected compound
metabolic products of an injected compound
injected imaging agents at very low concentrations

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The most commonly used hyperpolarized substrate is 13C-labelled pyruvate. Which enzymatic conversion process of this metabolite is most importantly used to characterize tumors in patients?

Pyruvate dehydrogenase (PDH)
Alanine transaminase (ALT)
Lactate dehydrogenase (LDH)
Fumarase

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What spatial resolution can be achieved under optimized conditions in preclinical studies in vivo when imaging hyperpolarized 13C-labelled substrates?

ca. 0.5 mm isotropically
ca. 2 mm isotropically
ca. 4 mm isotropically
ca. 8 mm isotropically

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What is observed when comparing simultaneously acquired results in tumors between hyperpolarized 13C-labelled pyruvate MRI and 18F-FDG PET scans?

Pyruvate-lactate conversion and 18F-FDG uptake match
Pyruvate-lactate conversion and 18F-FDG uptake match in some cases
Pyruvate-lactate conversion and 18F-FDG uptake do not match in some cases
Pyruvate-lactate conversion and 18F-FDG uptake do not match

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