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Jessica McKay

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Q&A with Lotte Bertelsen and Christoffer Lausten

                                        BY Jessica McKay

Christoffer, Lotte and Ellie, captured in midthought during our Skype interview

This month we sat down with Dr. Lotte Bertelsen, Dr. Christoffer Laustsen, and our youngest (and cutest!) MRM contributor, Lotte’s 8-month-old daughter Ellie. From their homes in Denmark, Christoffer and Lotte discussed the April Editor’s Pick: Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C, 15N-Urea. In this work, Lotte and Christoffer use MRI to assess renal function in diabetic and normal rats by measuring the hyperpolarized 13C-Urea gradient across the kidney.

21 April 2017, 04:44 PDT|Categories: Highlights-post, Highlights-QA|Tags: , , |

Q&A with Brian Hansen & Sune Jespersen

 

BY JESSICA MCKAY

This month’s Editor’s Pick features a project that makes kurtosis imaging more accessible to clinicians and researchers, alike, from a group in Denmark that includes our interviewees: Brian Hansen and Sune Jespersen. Diffusion kurtosis imaging (DKI) increases sensitivity to microstructural changes by extending the diffusion signal expression to account for non-Gaussian effects, but it typically requires time-consuming acquisitions with high diffusion weighting. Brian and Sune’s group had previously described a fast protocol, referred to as the 1-3-9 scheme, that includes three diffusion directions at a low b-value to determine the mean diffusivity and 9 specific diffusion directions at a higher b-value to calculate mean kurtosis [Hansen et al. MRM 69, 2013]. In this work, they extend the protocol to make it more robust to experimental imperfections by acquiring all 9 directions at the lower b-value, which they call 1-9-9. They further characterize the optimum b-values and propose a method to correct for imperfect diffusion directions. Keep reading to find out how their acquisition scheme expands the clinical value and feasibility of kurtosis imaging and you may even be inspired to add this ~1-minute scan onto your own protocol.

Q&A with Sebastiano Barbieri and Harriet Thoeny

BY JESSICA MCKAY

We sat down with Dr. Sebastiano Barbieri and Dr. Harriet Thoeny from Inselspital University Hospital to discuss their paper, “Impact of the Calculation Algorithm on Biexponential Fitting of Diffusion-Weighted MRI in Upper Abdominal Organs”. Sebastiano, who completed his Ph.D. at Jacobs University and the Fraunhofer Institute for Medical Image Computing in Germany, has a background in math and image processing. Harriet is a radiologist dedicated to urogenital and head and neck radiology with main research interest in functional MRI, and special focus on diffusion-weighted MRI. In their paper, they assess six different algorithms for fitting a biexponential IntraVoxel Incoherent Motion (IVIM) model.

Q&A with Dariya Malyarenko and Tom Chenevert

The March Editor’s Pick features Dr. Dariya Malyarenko and Dr. Tom Chenevert, from the University of Michigan. With a background in solid-state NMR and signal processing for biomarker discovery from cancer proteomics data, Dariya started in MRI as an NIH T32 trainee four years ago. Tom began his work in MRI 25 years ago at the University of Michigan. In their paper they perform a multicenter study to thoroughly characterize the sources of technical bias in quantitative diffusion weighted imaging (DWI), and identify gradient non-linearity as a major contributor.

Q&A with Tijl van der Velden and Dennis Klomp

Tijl and Dennis are scientists at Utrecht University and their paper on bilateral breast imaging and phosphorous spectroscopy is our Editor’s Pick for the month of December. The paper presents a unique bilateral coil array that allows them to acquire both 31P spectroscopic imaging and 1H high-resolution imaging in a single session. Their novel design included quadrature transmit coils and used a floating loop to achieve decoupling at the resonant frequencies of both phosphorous and hydrogen. We discussed their path in MRI research and the features and significance of this work.

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