MRM Q&A posts
By Pinar OzbaySurabhi Sood
Among the Editor’s picks for May comes a paper from the Center for Advanced Imaging at the University of Queensland, Australia. In their work, entitled ‘Echo Time-Dependent Quantitative Susceptibility Mapping Contains Information on Tissue Properties’, Surabhi Sood and Viktor Vegh used a 3-compartment model to explore the echo time dependence of Quantitative Susceptibility Mapping and how this trend is varying in different regions of the brain. We conducted this Skype interview on a Tuesday evening Eastern time, while Viktor Vegh and Surabhi Sood were having their Wednesday morning coffee.
BY Jessica McKayChristoffer, Lotte and Ellie, captured in midthought during our Skype interview
This month we sat down with Dr. Lotte Bertelsen, Dr. Christoffer Laustsen, and our youngest (and cutest!) MRM contributor, Lotte’s 8-month-old daughter Ellie. From their homes in Denmark, Christoffer and Lotte discussed the April Editor’s Pick: Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C, 15N-Urea. In this work, Lotte and Christoffer use MRI to assess renal function in diabetic and normal rats by measuring the hyperpolarized 13C-Urea gradient across the kidney.
By Agâh Karakuzu
In this April’s Editor’s pick, pieces from previous Highlights features are coming together. About a year ago Dr. Davide Piccini foreshadowed their collaborative study with NYU to incorporate XD-GRASP into their work on free-breathing motion correction. Seems like it was a productive year for Davide, as he not only delivered on his research promise, but also became a father. The Highlights team extends their sincerest congratulations to the Piccini family! We spoke to Davide and senior author, Prof. Matthias Stuber from the University of Lausanne, about their recent paper on Four Dimensional Respiratory Motion-Resolved Coronary MR Angiography.
BY AKSHAY CHAUDHARI
Today we sat down with Yun Jiang and Mark Griswold from Case Western Reserve University to chat a little about their recent Magnetic Resonance in Medicine manuscript, entitled, “MR fingerprinting using the quick echo splitting NMR imaging technique”. In this manuscript, the authors describe using a novel method to quantify relaxation properties of tissues with considerably lower radio frequency power deposition. Our circuitous conversation led us through some of the history of this work, through some of the specifics of the paper, and through the visions for quantitative MRI in the future. Maybe next time when you run into Mark, you may want to ask him if there are now showers in his lab space!
BY NIKOLA STIKOVNICU magnet – Jason Woods and Nara Higano
This month we are featuring a collaboration between the Cincinnati Children’s Hospital Medical Center, the Washington University in St. Louis and the University of Wisconsin – Madison. Nara Higano, Andrew Hahn, Jason Woods and colleagues used a converted orthopedic MRI scanner to measure tidal volume (the difference between lung volume in the inspired and expired state) in neonates. As you can imagine, we are talking small volumes here (on the order of tens of milliliters), and achieving this with 3D radial ultrashort echo-time (UTE) MRI is no small engineering feat that owes a great deal to some of the early MR projection reconstruction techniques.
March Cover Art
Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors, by Björn Lampinen, Filip Szczepankiewicz, Danielle van Westen, Elisabet Englund, Pia C Sundgren, Jimmy Lätt, Freddy Ståhlberg and Markus Nilsson.
March Editor’s Picks
MR fingerprinting using the quick echo splitting NMR imaging technique, by Yun Jiang, Dan Ma, Renate Jerecic, Jeffrey Duerk, Nicole Seiberlich, Vikas Gulani and Mark A. Griswold. Audioslides.
Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults, by Nara S. Higano, Andrew D. Hahn, Jean A. Tkach, Xuefeng Cao, Laura L. Walkup, Robert P. Thomen, Stephanie L. Merhar, Paul S. Kingma, Sean B. Fain and Jason C. Woods.
BY MATHIEU BOUDREAU
The February 2017 Editor’s Pick is from Kimberly Chan and Richard Edden, researchers at John Hopkins University and the F.M. Kirby Center for Functional Brain Imaging in Baltimore. Their paper presents a study aimed at optimizing the echo time for measuring glutathione using J-difference editing. Glutathione is the brain’s main antioxidant, and may play an important role in several psychiatric and neurological illnesses, such as schizophrenia, bipolar disorder, and Parkinson’s disease. We recently spoke with Kim and Richard about their project.
BY RYAN TOPFER
Among the Editor’s picks for February comes a work from the Center for Magnetic Resonance Research at the University of Minnesota, where they’ve paired loops with dipoles for a novel hybrid transceiver. Last year, we featured the work of Alexander Raaijmakers (second author of the current work) on the fractionated dipole antenna design and we published the feature under the headline “We need antennas – not coils!” To understand this seeming about-face, we confronted Arcan and Greg over Skype about their decision to defy their collaborator’s unconventional wisdom.
BY BENJAMIN DE LEENER, NIKOLA STIKOV
In early 2017, the Highlights team had our first ever in-person interview with authors of this January’s Editor’s pick. For this historic event, we met with Gabriel A. Devenyi and Jamie Near, researchers at the Douglas Mental Health University Institute in Montreal, and authors of the recent MRM article “Advanced Processing and Simulation of MRS Data Using the FID Appliance (FID-A)—An Open Source, MATLAB-Based Toolkit”. It was noon on Friday, and we decided to get an early start on the weekend by heading to a most Canadian interview location – a skating rink at Beaver Lake in Montreal. Over beer and bison hamburgers, we discussed spectroscopy, open science, and the musical inspiration behind the acronym FID-A.
BY BLAKE DEWEY
In the early days of 2017, we sat down (virtually, of course) to have a conversation with Moritz Zaiss, Johannes Windschuh and Alexander Radbruch. Our topic was their recent MRM paper, “Downfield-NOE-Suppressed Amide-CEST-MRI at 7 Tesla Provides a Unique Contrast in Human Glioblastoma”. Chemical Exchange Saturation Transfer (CEST) imaging is an indirect imaging technique for the protons of certain metabolites, where saturation is applied off-resonance (with respect to water). Saturated protons are then allowed to exchange with water protons and then imaged using conventional imaging methods. However, frequency selection is not always enough to specifically target a functional group, such as amide groups, which are common in CEST imaging methods, producing a “mixed” contrast. Moritz, Johannes and Alexander, together with others in their group, have been slowly removing confounding effects in an attempt to isolate the measurement of amide proton transfer. In this paper, they continue their efforts by removing the downfield Nuclear Overhauser Effect (NOE), resulting in clinically relevant findings and correlation with gadolinium uptake in patients with glioblastoma.